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ClinicalTrials.gov public records Last synced Oct 28, 2026, 1:14 AM EDT

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Showing 1273–1296 of 2,082 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Smoking Behavior Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Study of Mobile Phone Support for the DC Tobacco Quitline

NCT01817842
View directory record Official record
Conditions
Smoking Cessation
Interventions
Mobile EX cessation support, DC Quitline Support, Device Control
Behavioral
Lead sponsor
Truth Initiative
Other
Eligibility
18 Years and older
Enrollment
803 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 26, 2013 · Synced Oct 28, 2026, 1:14 AM EDT
Completed Not applicable Interventional Results available

Promoting Oral Health Among Smokers Randomized Trial

NCT02347124
View directory record Official record
Conditions
Oral Disease, Smoking
Interventions
Usual Care Control, Enhanced Intervention
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
718 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 8, 2019 · Synced Oct 28, 2026, 1:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Just Kwit: Mobile Intervention for Tobacco Cessation

NCT03538678
View directory record Official record
Conditions
Smoking Cessation
Interventions
Kwit smartphone app
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 30 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 18, 2021 · Synced Oct 28, 2026, 1:14 AM EDT
Terminated Not applicable Interventional Results available

Analysis of Aldehyde Biomarkers of Exposure and Host Response

NCT00482690
View directory record Official record
Conditions
Smoking Cessation
Interventions
nicotine polacrilex, nicotine transdermal system, nicotine inhaler
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 7, 2023 · Synced Oct 28, 2026, 1:14 AM EDT
Completed Phase 2 Interventional Results available

Concurrent Alcohol and Smoking Treatment: Effects on Alcohol Relapse Risk

NCT00861146
View directory record Official record
Conditions
Tobacco Use Cessation, Alcohol-related Disorders
Interventions
behavioral counseling plus contingency management
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
Newington, Connecticut • West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 3, 2020 · Synced Oct 28, 2026, 1:14 AM EDT
Completed Phase 4 Interventional

Bupropion for Hospitalized Smokers With Acute Cardiovascular Disease

NCT00181818
View directory record Official record
Conditions
Smoking, Myocardial Infarction, Unstable Angina, Cardiovascular Disease
Interventions
bupropion SR (sustained-release)
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
248 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2003
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 16, 2005 · Synced Oct 28, 2026, 1:14 AM EDT
Terminated Phase 3 Interventional Results available

Varenicline and Alcohol in Inpatient Addictions Program (IAP)

NCT01169610
View directory record Official record
Conditions
Alcoholism, Nicotine Dependence
Interventions
Varenicline
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 20, 2019 · Synced Oct 28, 2026, 1:14 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

ACT Lung Health Intervention: Phase Two

NCT06945120
View directory record Official record
Conditions
Smoking Cessation, Smoking Behaviors, Smoking, Tobacco, Smoking, Cigarette, Smoking (Tobacco) Addiction
Interventions
ACT Lung Health Intervention
Behavioral
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
18 Years to 100 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 13, 2026 · Synced Oct 28, 2026, 1:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Computer-Assisted Tobacco Interventions in Dental Offices

NCT01584882
View directory record Official record
Conditions
Smoking
Interventions
CATI Tool
Behavioral
Lead sponsor
HealthPartners Institute
Other
Eligibility
18 Years to 100 Years
Enrollment
548 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Oct 28, 2026, 1:14 AM EDT
Completed Not applicable Interventional

Novel Treatment to Enhance Smoking Cessation Before Cancer Surgery

NCT02402023
View directory record Official record
Conditions
Smoking Cessation
Interventions
Contingency Management (CM), Standard of Care (SC)
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
New Haven, Connecticut • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Oct 28, 2026, 1:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Electronic Cigarette Flavors on Abuse Liability in Smokers (P3-Taste)

NCT05971823
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Tobacco product administration and assessment
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 28, 2026, 1:14 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Nicotine Delivery Systems: Research & Treatment

NCT00108342
View directory record Official record
Conditions
Smoking
Interventions
Nicotine gum - 2 mg and 4 mg, Nicotine lozenges - 2 mg and 4 mg, Nicotine inhaler (4 mg yield) - low and high "dosage" by frequency of puffing, Computer learning
Drug · Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
21 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
West Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 4, 2014 · Synced Oct 28, 2026, 1:14 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Varenicline Augmentation of Patch Outcomes in Heavy Drinkers' Smoking Cessation

NCT02859142
View directory record Official record
Conditions
Smoking Cessation, Alcohol Drinking
Interventions
Chantix, Behavioral Counseling Sessions, NicodermCQ, Placebo
Drug · Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 85 Years
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 27, 2021 · Synced Oct 28, 2026, 1:14 AM EDT
Completed No phase listed Observational

Mobile App Based Personalized Solutions and Tools for Medication Adherence of Rx Pills

NCT02072005
View directory record Official record
Conditions
Cigarette Smoking
Interventions
mSMART smartphone application
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 31, 2014 · Synced Oct 28, 2026, 1:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Supporting Smoke-Free Policy Compliance in Public Housing

NCT05016505
View directory record Official record
Conditions
Smoking, Smoking Cessation, Smoking Reduction, Smoking Behaviors
Interventions
Reduction (relocation and reduction of personal smoking) and cessation, Resident Endorsement
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
405 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 28, 2026, 1:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Learning-Theory-Based Smoking Cessation Strategies

NCT01368653
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Standard treatment, Standard treatment+practice quitting, Very low nicotine cigarettes
Behavioral · Drug
Lead sponsor
Rutgers University
Other
Eligibility
18 Years and older
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Oct 28, 2026, 1:14 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Tailored Tobacco Quitline for Rural Veterans

NCT01592695
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Nicotine replacement therapy - transdermal nicotine patch, Tailored behavioral intervention, Tobacco quit line referral, Nicotine replacement therapy - nicotine gum, Nicotine replacement therapy - nicotine lozenge, Bupropion Sustained Release, Varenicline, Combination pharmacotherapy - transdermal nicotine patch + nicotine gum, Combination pharmacotherapy - transdermal nicotine patch + nicotine lozenge, Combination pharmacotherapy - transdermal nicotine patch + bupropion, Alcohol use risk reduction, Behavioral activation for the treatment of depression, Behavioral management of post-cessation weight gain
Drug · Behavioral
Lead sponsor
Iowa City Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 99 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 2, 2019 · Synced Oct 28, 2026, 1:14 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

E-Cigarette and Cigarette Nicotine Delivery and Abuse Liability in Cigarette Smokers and Dual Users

NCT03943706
View directory record Official record
Conditions
Tobacco Use
Interventions
Not listed
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 50 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 19, 2020 · Synced Oct 28, 2026, 1:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Impact of E-cigarette Nicotine Concentration on Compensation

NCT05887947
View directory record Official record
Conditions
Smoking Cessation
Interventions
Electronic Cigarette with 5% Nicotine Concentration, Electronic Cigarette with 1.8% Nicotine Concentration
Device
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Oct 28, 2026, 1:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of e-Cigarettes on Perceptions and Behavior - Substudy 1

NCT04399031
View directory record Official record
Conditions
Electronic Cigarette Use, Cigarette Use, Electronic, Vaping, Cigarette Smoking
Interventions
E-cigarette e-liquid
Drug
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 11, 2023 · Synced Oct 28, 2026, 1:14 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Pilot Study to Evaluate the Safety and Efficacy of Ariva® Silver Wintergreen in Reducing Cigarette Craving in Smokers

NCT01337830
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking
Interventions
Ariva® Silver Wintergreen, Silver Wintergreen
Other
Lead sponsor
Star Scientific, Inc
Industry
Eligibility
23 Years to 72 Years
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Martinsburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 24, 2014 · Synced Oct 28, 2026, 1:14 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

The Effects of Sedatives on Tobacco Use Disorder Version 2

NCT05505630
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Ketamine, Midazolam, Dexmedetomidine, Saline
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 28, 2026, 1:14 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Comparison of Smoking and Vaping in Families

NCT02500238
View directory record Official record
Conditions
Smoking
Interventions
Saliva sample, Urine Sample, Toe nail clippings, Breath carbon monoxide test
Other
Lead sponsor
University of Florida
Other
Eligibility
6 Years to 17 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
2
States / cities
Gainesville, Florida • Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 28, 2018 · Synced Oct 28, 2026, 1:14 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Comparison of Low Yield Cigarettes in African Americans vs. Whites

NCT01058876
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Deuterated nicotine and cotinine
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 24, 2013 · Synced Oct 28, 2026, 1:14 AM EDT