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ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:09 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 798 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking Cigarette Clear all

Conditions: Electronic Cigarette Use
Interventions: Health Assessments; Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 21 Years and older
Enrollment: 600 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Smoking Cessation
Interventions: Gradual Cessation, Gradual Cessation w/ Quitbit; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 124 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Cigarette Smoking, Nicotine Dependence
Interventions: Counseling Intervention, Information Intervention; Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 13 Years to 18 Years
Enrollment: 1,058 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Vaping, Adolescent, Electronic Cigarette Use, Nicotine, Cannabis
Interventions: Vaping Device Labeling; Other
Lead sponsor: University of Southern California; Other
Eligibility: 11 Years to 19 Years
Enrollment: 3,048 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Smoking, Cigarette, Breastfeeding
Interventions: Integrated intervention of smoking cessation and breastfeeding, Attention placebo control; Behavioral
Lead sponsor: Xiaozhong Wen; Other
Eligibility: 18 Years and older · Female only
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Cigarette Smoker, Current Every Day Smoker, Student
Interventions: APPSPIRE, Focus Group, Survey Administration; Behavioral · Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years to 24 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2020
U.S. locations: 2
States / cities: Houston, Texas

Conditions: Menthol Cigarettes, Smoking Behavior, Cigarette Use
Interventions: Message Exposure via Discrete Choice Experiment; Behavioral
Lead sponsor: Georgia State University; Other
Eligibility: 21 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: Santa Barbara, California • Atlanta, Georgia

Conditions: Cigarette Smoking, Tobacco Smoking, Smoking, Tobacco
Interventions: nicotine patch plus nicotine gum/lozenge, Intensive Alcohol Intervention; Drug · Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 75 Years
Enrollment: 352 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Attentional Bias, Smoking Cues, Positive Perceptions About Cigarette Smoking, Social Norms, Smoking Susceptibility
Interventions: E-cigarette ad exposure, non e-cigarette TV commercials; Behavioral · Other
Lead sponsor: Trustees of Dartmouth College; Other
Eligibility: 14 Years to 17 Years
Enrollment: 139 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Cigarette Smoking
Interventions: Quest; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 65 Years
Enrollment: 246 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2013
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking Cessation
Interventions: AXS-05 (dextromethorphan-bupropion), Bupropion, Placebo; Drug
Lead sponsor: Axsome Therapeutics, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 705 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 28
States / cities: Phoenix, Arizona • Little Rock, Arkansas • Lemon Grove, California + 24 more

Conditions: E-cigarette Use, Vaping
Interventions: Peer Messaging, Peer Coaching via Text, Gamification, E-Cigarette Cessation Materials; Behavioral · Other
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 13 Years to 19 Years
Enrollment: 71 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Lung Carcinoma, Solitary Pulmonary Nodule, Cigarette Smoking Behavior
Interventions: Computed Tomography, fluorodeoxyglucose F-18, Fluorine F 18 L-glutamate Derivative BAY94-9392, Laboratory Biomarker Analysis, Positron Emission Tomography, Positron Emission Tomography (PET); Procedure · Radiation · Drug + 1 more
Lead sponsor: Vanderbilt-Ingram Cancer Center; Other
Eligibility: 40 Years to 80 Years
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 2
States / cities: Nashville, Tennessee

Conditions: Anxiety Disorders, Depression, Psychological Distress, Tobacco Dependence, Smoking, Tobacco, Smoking, Cigarette
Interventions: PFI for Smoking & Distress Tolerance, PFI for Smoking Only; Behavioral
Lead sponsor: University of Houston; Other
Eligibility: 18 Years and older
Enrollment: 121 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cigarette Smoking
Interventions: C2Q-Teen app, NCI's QuitSTART app, Written smoking cessation materials only; Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 13 Years to 19 Years
Enrollment: 146 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Smoking, Cigarette
Interventions: Package standardization; Behavioral
Lead sponsor: RAND; Other
Eligibility: 21 Years to 34 Years
Enrollment: 433 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Nicotine Dependence, Tobacco Use Disorder
Interventions: Varenicline Pill, Contingency management, Counseling; Drug · Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 40 Years
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 3
States / cities: Charleston, South Carolina • Lancaster, South Carolina • Pickens, South Carolina

Conditions: Cigarette Smoker, Tobacco Use Disorder
Interventions: Nicotine Lozenge, Nicotine Patch, Placebo, Tobacco Cessation Counseling, Varenicline; Drug · Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 631 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking
Interventions: P3L, VUSE, CC; Other
Lead sponsor: Philip Morris Products S.A.; Industry
Eligibility: 19 Years to 65 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Raleigh, North Carolina

Conditions: Tobacco Dependence, Schizophrenia
Interventions: Sampling Research Cigarettes; Combination Product
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 60 Years
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Catonsville, Maryland

Conditions: Smoking, Smoking Cessation
Interventions: Coordinated Care, Usual Care; Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 633 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Cigarette Smoking, Computed Tomography, Positron Emission Tomography, Questionnaire Administration; Behavioral · Procedure · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 50 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Cigarette Smoking
Interventions: Experimental Tobacco Marketplace; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 9 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Smoking
Interventions: Nicotine Lozenge, Placebo Lozenge, Abstinence Advisement; Drug · Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: Rochester, Minnesota

Search by objective public record fields.

Effects of E-cigarette Use on Health

Cigarette Reduction Using the Quitbit Digital Lighter and Mobile Application for Smoking Cessation: a Randomized Controlled Trial

School Nurse-Delivered Smoking Cessation Intervention

Nicotine and Cannabis Vape Labeling Experiment - Spring 2025

Lung and Breast Cancer Prevention by an Integrated Intervention of Maternal Smoking Cessation and Breastfeeding

APPSPIRE App in Preventing Students From Smoking

DoubleTake: Effect of Message Exposure Via a Discrete Choice Experiment With Eye-Tracking on Quit Attempts Among Adults Who Smoke Menthol Cigarettes

Enhancing Smoking Cessation in the Homeless Population

Trial on the Effect of E-cigarette Advertising on Cigarette Perceptions in Adolescents

Use and Harm Exposure in New Low Nicotine Cigarettes

Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT)

Vaper to Vaper: A Multimodal Mobile Peer Driven Intervention to Support Adolescents in Quitting Vaping

18F-FSPG PET/CT in Imaging Patients With Newly Diagnosed Lung Cancer or Indeterminate Pulmonary Nodules

Personalized Feedback for Distress Intolerant Smokers

Developing a Smartphone App With Mindfulness Training for Teen Smoking Cessation

The Impact of Standardized Tobacco Product Packaging on Young Adults in the Retail Environment

E-cigarette Cessation in Adults Who Co-use Cannabis

Varenicline and Combined NRT for Smoking Cessation

User Acceptability of a Nicotine Lactate Delivery System (P3L)

Cigarette Smoking in Smokers With and Without Schizophrenia

Connect to Quit for Smoking

Free-Base Nicotine or Nicotine Salt e-Liquids in Current E-Cigarette Smokers, PeloPET Study

Behavioral Economic Methods for Assessing Tobacco Product Abuse Liability: Study 7

Pilot Study: Preoperative Nicotine Lozenges