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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:47 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 241–264 of 798 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking Cigarette Clear all

Conditions: E-cigarettes, Oxidative Stress, Inflammation
Interventions: e-cigarette, empty (-cigarette sham control); Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 148 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Smoking
Interventions: Experimental App, Active Comparator App; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 511 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking, Tobacco, Smoking, Smoking, Cigarette
Interventions: Tobacco retailer, Non-tobacco retailer; Behavioral
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 21 Years to 65 Years
Enrollment: 343 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking, Tobacco Smoking, Tobacco Use
Interventions: 1601A, 1601B; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years and older
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016
U.S. locations: 1
States / cities: High Point, North Carolina

Conditions: Alcohol Use Disorder, Depressive Disorder, Cigarette Smoking
Interventions: Intermittent theta burst transcranial magnetic stimulation; Device
Lead sponsor: Stanford University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 2
States / cities: Palo Alto, California • Stanford, California

Conditions: Tobacco Use, Tobacco Smoking
Interventions: Product A, Product B, Product C, Product D, Product E, Product F, Product G, Product H, Product I; Other
Lead sponsor: British American Tobacco (Investments) Limited; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Smoker
Interventions: Cigarettes, Snus; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2018
U.S. locations: 3
States / cities: Minneapolis, Minnesota • Buffalo, New York • Columbus, Ohio

Conditions: Acute Lung Injury, Pulmonary Injury, Electronic Cigarette Use, Electronic Cigarette Related Lung Injury
Interventions: Not listed
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 80 Years
Enrollment: 101 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Smoking, Cigarette, Electronic Cigarettes
Interventions: Spectrum Research Cigarettes; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 15 Years to 20 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Smoking, Cigarette, Smoking E-cigarette, Healthy Volunteer
Interventions: [18F]NOS; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 45 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2028
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Nicotine Dependence
Interventions: Oral Nicotine Pouch, Smoking Cue Reactivity Task; Other · Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 21 Years to 55 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Smoking Behaviors, Cigarette Smoking
Interventions: Nicotine Messaging, Cigarette Condition; Other
Lead sponsor: Andrew Strasser; Other
Eligibility: 21 Years and older
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cigarette Smoking
Interventions: Group counseling and nicotine replacement, Group counseling, nicotine replacement, and text messaging support; Behavioral
Lead sponsor: RAND; Other
Eligibility: 18 Years to 25 Years
Enrollment: 77 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 3
States / cities: Los Angeles, California • Venice, California

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Focus Group, Interview, Smoking Cessation Intervention, Survey Administration; Behavioral · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 14 Years to 24 Years
Enrollment: 179 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Tobacco Use Disorder, Cannabis Use Disorder
Interventions: Varenicline, Placebo; Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Chronic Pain, Smoking, Cigarette
Interventions: SPECTRUM NRC 102/103 investigational cigarettes, SPECTRUM NRC 600/601 investigational cigarettes; Other
Lead sponsor: Duke University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Electronic Cigarette Use
Interventions: Subox Mini C with Avail 18 mg nicotine salt (protonated), Subox Mini C with Avail 18 mg nicotine (unprotonated), Own brand cigarette; Other
Lead sponsor: Eastern Virginia Medical School; Other
Eligibility: 21 Years to 55 Years
Enrollment: 11 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Norfolk, Virginia

Conditions: E-Cig Use
Interventions: Hyperpolarized Xenon -129 MRI; Drug
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Opioid Use Disorder, Tobacco Use Disorder
Interventions: Deep TMS System With H4 Coil; Device
Lead sponsor: Payel Roy; Other
Eligibility: 22 Years to 70 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania

Conditions: Smoking
Interventions: Repetitive transcranial magnetic stimulation, MagStim Rapid2, Sham repetitive transcranial magnetic stimulation; Device
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 55 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Tobacco Use Disorder
Interventions: Behavioral Therapy; Behavioral
Lead sponsor: Peter Gariti; Other
Eligibility: 21 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1999 – 2002
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cardiovascular Disease, Cigarette Smoking
Interventions: Subject's usual brand (UB) tobacco product; Other
Lead sponsor: R.J. Reynolds Tobacco Company; Industry
Eligibility: 26 Years to 49 Years · Male only
Enrollment: 168 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Lincoln, Nebraska

Conditions: Tobacco Use Disorder, Oral Nicotine Pouch Use, Smoking Behaviors, Harm Reduction, Toxic Effect of Tobacco and Nicotine, Carcinogenesis
Interventions: ZYN; Device
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 77 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cigarette Smoking, Overweight, Obesity
Interventions: Weight gain prevention and smoking cessation, Smoking cessation; Behavioral
Lead sponsor: Consumer Wellness Solutions; Industry
Eligibility: 18 Years and older
Enrollment: 2,540 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Seattle, Washington

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ECigs, Inflammation and Oxidative Stress

Smartphone Application for Smoking Cessation

GeoScan and Remote Geo Smoking Study: Neural and Behavioral Correlates of Smokers' Exposure to Retail Environments

CSD1601: A Study to Evaluate the Exposure to Tar and Nicotine From Two Cigarette Products That Contain a Menthol Capsule in the Filter

Intermittent Theta Burst for the Treatment of Alcohol Use Disorders in Veterans

A Study to Characterize Nicotine Pharmacokinetics and Subjective Effects of Nicotine Pouches in Adult Cigarette Smokers

Methods Project 4: Clinical Trial

Electronic Nicotine Delivery Devices and Potential Progression to Acute Lung Injury

Evaluating New Nicotine Standards for Cigarettes - Project 3

Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation

Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use

Impact of Nicotine Messaging on Beliefs and Behavior

Text Messaging-Based Smoking Cessation Program for Homeless Youth

Smoking Cessation Intervention Development for Homeless Youth

Varenicline for the Treatment of Cannabis and Tobacco Use Disorders in Veterans

Low Nicotine Cigarettes, Smoking, and Chronic Pain

Effects of Nicotine Salt Aerosol on Cigarette Smokers

Hyperpolarized Xenon-129 MR Imaging of the Lung

Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder

Insular Inhibitory Neuromodulation to Reduce Cigarette Craving and Alter Brain Function in Smokers

Combining a Smoke Ending Aid With Behavioral Treatment - 1

Cardiovascular Disease Biomarkers in Smokers and Moist Snuff Consumers

Switching to Potential Reduced Exposure Products in Adult Smokers

Comparative Effectiveness of Adding Weight Control to Smoking Cessation Quitlines