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ClinicalTrials.gov public records Last synced Nov 15, 2026, 8:23 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 313–336 of 798 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking Cigarette Clear all

Conditions: Smoking (Tobacco) Addiction, Smoking ( Cigarette), Tobacco, Tobacco Abstinence, Quitting Smoking, Smoking Cessation
Interventions: Not listed
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Cigarette Smoking, Current Smoker
Interventions: Educational Intervention, Questionnaire Administration, Smoking Cessation Intervention; Other · Behavioral
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years to 35 Years
Enrollment: 579 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cigarette Smoking, Mindfulness
Interventions: mindfulness for smokers; Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Smoking, Cigarette, Nicotine Dependence
Interventions: Nicotine (electronic cigarette), Nicotine (nicotine pouch); Other
Lead sponsor: Brown University; Other
Eligibility: 21 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Smoking, Tobacco
Interventions: FT25614, FT25615, FT25616; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 480 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 5
States / cities: Fort Lauderdale, Florida • Atlanta, Georgia • Chicago, Illinois + 2 more

Conditions: Cigarette Smoking Among Patients Currently Receiving Methadone or Buprenorphine Treatment for Opioid Dependence
Interventions: incentive-based contingency management; Behavioral
Lead sponsor: University of Vermont Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 170 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2013
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: THC, Cannabis, Cannabis Smoking, Cannabis Use, Unspecified, Cigarette Smoking, Tobacco Use, Nicotine Dependence, Nicotine Withdrawal, Cardiovascular Risk Factor
Interventions: Smoked Cannabis, Vaped Cannabis, Tobacco Cigarette; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years and older
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Nicotine Dependence, Nicotine Dependence, Cigarettes, Tobacco Use, Tobacco Smoking
Interventions: Virginia Tobacco flavored JUUL 5% ENDS, Cool Mint flavored JUUL 5% ENDS, Mango flavored JUUL 5% ENDS, Creme Brulee flavored JUUL 5% ENDS, VUSE Solo e-cigarette, Nicorette White Ice Mint 4mg nicotine polacrilex gum, Usual Brand combustible cigarette; Other
Lead sponsor: Juul Labs, Inc.; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 67 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Smoking Cessation
Interventions: Electronic Cigarette with 5% Nicotine Concentration, Electronic Cigarette with 1.8% Nicotine Concentration; Device
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 21 Years and older
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Nicotine Dependence
Interventions: Nicotine patch - transdermal, placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 60 Years
Enrollment: 127 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Electronic Cigarette Use, Pulmonary Disease
Interventions: Pulmonary Group, Healthy Control; Other
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Tobacco Use
Interventions: Not listed
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 99 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Smoking, Cigarette, Alveolar Bone Grafting, Wound Healing, Bone Healing, Tooth Extraction Site Healing
Interventions: observational study; Other
Lead sponsor: Marquette University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: E-cigarette Use, Vaping, Nicotine Dependence
Interventions: Varenicline 1mg BID, Placebo; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 326 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 2
States / cities: New Haven, Connecticut • Charleston, South Carolina

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Nicotine Replacement, Questionnaire Administration, Vaping; Drug · Other · Device
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years and older
Enrollment: 1,500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: COPD, Smoking, Tobacco Use
Interventions: Cigarette, THS; Other
Lead sponsor: Philip Morris Products S.A.; Industry
Eligibility: 40 Years and older
Enrollment: 290 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 46
States / cities: Clearwater, Florida • Coral Gables, Florida • Davie, Florida + 24 more

Conditions: Smoking
Interventions: Not listed
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2006
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking
Interventions: blu™ Classic Tobacco rechargeable (2.4% nicotine, glycerin vehicle), blu™ Classic Tobacco rechargeable (2.4% nicotine, glycerin/PG vehicle), blu™ Magnificent Menthol rechargeable (2.4% nicotine, glycerin vehicle), blu™ Classic Tobacco rechargeable (1.6% nicotine, glycerin vehicle), blu™ Classic Tobacco rechargeable (1.6% nicotine, glycerin/PG vehicle), Marlboro Cigarette; Other
Lead sponsor: Lorillard Tobacco Company; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 1
States / cities: Lincoln, Nebraska

Conditions: Smoking Prevention and Control
Interventions: Non-Menthol Cigarettes, Tobacco Flavored E-cigarettes, Menthol Cigarettes, Menthol Flavored E-cigarettes; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Anxiety Disorders, Anxiety, Tobacco Dependence, Smoking, Cigarette, Smoking, Tobacco
Interventions: Personalized Feedback Intervention, Smoking Information Control; Behavioral
Lead sponsor: University of Houston; Other
Eligibility: 18 Years to 65 Years
Enrollment: 95 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cigarette Smoking
Interventions: mSMART smartphone application; Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Reduction
Interventions: Varenicline Tartrate, Placebo, Electronic cigarette; Drug · Other
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 21 Years and older
Enrollment: 500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 2
States / cities: Kansas City, Missouri

Conditions: Smoking, Nicotine Dependence, Addiction, Smoking, Cigarette
Interventions: Real cTBS, Sham cTBS; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Electronic Cigarette Use
Interventions: Menthol-flavored e-cigarette, Tobacco-flavored e-cigarette; Other
Lead sponsor: Florida International University; Other
Eligibility: 21 Years to 35 Years
Enrollment: 250 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Miami, Florida

Search by objective public record fields.

Measuring Communal Coping in Dual-smoking Couples Making a Quit Attempt

Quit4Health Intervention in Supporting Smoking Cessation and Preventing Smoking Initiation in Young Adults

Mindfulness Training for Smokers Online Feasibility Study

Using ANDS to Reduce Harm for Low SES Cigarette Smokers

A Study to Determine the Effect of Access to Multiple Tobacco Flavor Options on Smoking Abstinence Among Primary Cigarette Smokers Using an Electronic Nicotine Delivery System

Incentive-based Smoking Cessation for Methadone Patients

THC Crossover Study

United States Pre-Market Tobacco Application Pharmacokinetics

Impact of E-cigarette Nicotine Concentration on Compensation

Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging

Factors That Impact the Relationship Between Pulmonary Status and Susceptibility to Electronic Cigarette Use

Baby Albert: Electronic Cigarette Pharmacokinetics (PK) and Abuse Liability

Wound Healing Following Extraction and Ridge Preservation in Smokers and Non-smokers

A Trial of Varenicline for E-cigarette Cessation

A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior

Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS

Research Study on the Effects of Smoking on Arteries

Characterization of Nicotine Exposure and Urge-to-Smoke Following Use of Electronic and Conventional Cigarettes

Impact of Cigarette and E-cigarette Menthol Regulation on Current Smokers of Menthol Cigarettes

Personalized Feedback for Smokers With Elevated Anxiety Sensitivity

Mobile App Based Personalized Solutions and Tools for Medication Adherence of Rx Pills

Switching to E-cigarettes in Smokers Not Interested in Quitting

Nicotine TMS EFT Smoking Pilot Study

Effect of Menthol on ENDS Users' Addiction and Exposure