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ClinicalTrials.gov public records Last synced Nov 15, 2026, 8:54 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 337–360 of 798 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking Cigarette Clear all

Conditions: Tobacco Use Disorder, Smoking Cessation
Interventions: Nicotine Polacrilex Gum (2 mg), Cognitive Behavioral Group Therapy (CBGT); Drug · Behavioral
Lead sponsor: University of Hawaii; Other
Eligibility: 18 Years to 80 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Honolulu, Hawaii

Conditions: Smoking
Interventions: Very low nicotine content cigarettes, Normal nicotine content cigarettes; Drug
Lead sponsor: Saul Shiffman; Other
Eligibility: 18 Years and older
Enrollment: 312 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: HIV
Interventions: Standardized Research Electronic Cigarette; Device
Lead sponsor: Brown University; Other
Eligibility: 18 Years and older
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Nicotine Dependence
Interventions: Nicotine patch, ENDS, Placebo patch, Placebo ENDS; Drug · Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Healthy, Cigarette Smoking
Interventions: 20K EU CCRE; Biological
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 50 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Cigarette Smoking
Interventions: Harm Reduction Tax - Normal Nicotine Cigarettes Available, Harm Reduction Tax - Normal Nicotine Cigarettes Not Available, Modified Risk Tobacco Product Tax - Normal Nicotine Cigarettes Available, Modified Risk Tobacco Product Tax - Normal Nicotine Cigarettes Not Available, Nicotine Content Tax - Normal Nicotine Cigarettes Available, Nicotine Content Tax - Normal Nicotine Cigarettes Not Available, Tobacco Parity Tax - Normal Nicotine Cigarettes Available, Tobacco Parity Tax - Normal Nicotine Cigarettes Not Available; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 316 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Buffalo, New York • Roanoke, Virginia

Conditions: Nicotine Dependence, E-cigarette Use
Interventions: Nicotine Level 1 (0mg/ml), Nicotine Level 2 (36mg/ml), Nicotine Level 3 (59mg/ml); Other
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 44 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking Cessation, Smoking, Cigarette
Interventions: text-only PWL, low arousal graphic PWL, high arousal graphic PWL, absolute risk, relative risk; Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: 19 Years to 64 Years
Enrollment: 3,213 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Tobacco Dependence
Interventions: Reduced Nicotine Content Cigarettes, Usual Nicotine Content Cigarettes; Drug
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 245 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 2
States / cities: Boston, Massachusetts • Hershey, Pennsylvania

Conditions: Alcohol Drinking, Cigarette Smoking Toxicity
Interventions: Reduced nicotine cigarettes; Drug
Lead sponsor: Battelle Memorial Institute; Other
Eligibility: 21 Years to 65 Years
Enrollment: 47 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cigarette Smoking
Interventions: Research ENDS S-TA-U001, Nicorette Inhalator; Drug
Lead sponsor: NJOY, Inc.; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Burbank, California

Conditions: Cigarette Smoking Behavior
Interventions: Control, Product Category Score, Product Category Rank, Product Tiers; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Smoking Cessation, Harm Reduction
Interventions: d-cycloserine, Juul e-cigarette; Drug · Other
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Vaping
Interventions: Youth Perceptions of Influencer Age and Fitness Contexts in E-Cigarette Marketing; Other
Lead sponsor: University of Southern California; Other
Eligibility: 14 Years to 17 Years
Enrollment: 700 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Nicotine Addiction
Interventions: Nicotine polacrilex, Placebo, satiety, abstinence; Drug · Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 54 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Vaping
Interventions: Not listed
Lead sponsor: Yale University; Other
Eligibility: 12 Years to 15 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: New Haven, Connecticut • Boston, Massachusetts

Conditions: Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions: Social media-based education, counseling, and support, Nicotine replacement therapies (NRT), Gamification; Behavioral · Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 121 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Perceptions of Tobacco Products
Interventions: Each intervention will be a picture of a social media post. The posts will vary (in a 3X2 factorial design) the type of flavor described and whether concealability is described.; Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 14 Years to 17 Years
Enrollment: 4,500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Smoking
Interventions: transdermal nicotine replacement therapy; Drug
Lead sponsor: Duke University; Other
Eligibility: 21 Years and older
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: E-Cig Use
Interventions: Viewing e-cigarette ads; Other
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years to 26 Years
Enrollment: 62 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Tobacco Smoking
Interventions: Nicotine Patch, E-cigarette; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 65 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cannabis Use, Tobacco Use, Electronic Cigarette Use
Interventions: THC High Dose, THC Low Dose, THC 0mg, E-Cigarette Full Nicotine, E-Cigarette Placebo Nicotine; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cigarette Smoking-Related Carcinoma, Lung Carcinoma
Interventions: Biospecimen Collection, Bronchoscopy, Canakinumab, Carbon Monoxide Measurement, Survey Administration; Procedure · Biological · Other
Lead sponsor: Peter Shields; Other
Eligibility: 40 Years to 73 Years
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: Non-Interventional; Other
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 30 Years to 87 Years
Enrollment: 1,574 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009
U.S. locations: 40
States / cities: Adamsville, Alabama • Foothill Ranch, California • Huntington Beach, California + 37 more

Search by objective public record fields.

Quit-Smoking Study for Native Hawaiians

Very-Low Nicotine Cigarettes and Non-Daily Smokers

Health Effects of the Standardized Research E-Cigarette in Smokers With HIV Smokers With HIV

Electronic Nicotine Delivery Systems as a Smoking Cessation Treatment

A Study of Inhalation of 20,000 EU CCRE and Mucociliary Clearance (MCC) in Otherwise Healthy Individuals Who Are Current Cigarette Smokers

Effects of Tax Proposals and Cigarette Availability on Tobacco Purchasing

Sex Differences in E-Cigarette Perception

Pictorial Warning Labels & Memory for Relative & Absolute Cigarette Health-risk Information Over Time in Adult Smokers

Reduced Nicotine Cigarettes in Smokers With Mood and Anxiety Disorders

Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder

Nicotine Pharmacokinetics From Research Electronic Nicotine Delivery System S-TA-U001 in Smokers and E-Cigarette Users

Effects of Tobacco Abuse Liability-dependent Taxes in the ETM

Assisting Smokers to Switch to an e-Cigarette by Accelerating Learning of Adaptive Habits Using D-cycloserine

Influencer Marketing and Adolescent E-cigarette Use

Acute and Chronic Nicotine Modulation of Reinforcement Learning

A Virtual Reality Vaping Prevention Intervention for Adolescents

Engaging Sexual and Gender Minority Cigarette Smokers Into Social Media-based Treatment

Social Media Influences on Engagement and Susceptibility to Non-combustible Tobacco Product Use Among Youth and Young Adults (AYA)

Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment

Responses to E-Cigarette Advertising

E-cigarettes to Promote Smoking Reduction Among Individuals With Schizophrenia

Effect of Cannabis on E-Cigarette Use Behavior

Evaluation of Canakinumab in High-Risk Former-Smokers

Prevalence of Chronic Airway Obstruction in Subjects With a History of Cigarette Smoking in a Primary Care Setting