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ClinicalTrials.gov public records Last synced Nov 15, 2026, 9:40 AM EST

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Showing 361–384 of 798 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking Cigarette Clear all

Conditions: Smoking, Tobacco, Smoking Behaviors
Interventions: Moist Snuff, Camel Snus, Cigarettes, No tobacco usage; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 19 Years and older
Enrollment: 320 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010
U.S. locations: 6
States / cities: DeLand, Florida • Miramar, Florida • Stockbridge, Georgia + 2 more

Conditions: Smoking Cessation, Smoking Behaviors, Smoking, Tobacco, Smoking, Cigarette, Smoking (Tobacco) Addiction
Interventions: ACT Lung Health Intervention; Behavioral
Lead sponsor: Dana-Farber Cancer Institute; Other
Eligibility: 18 Years to 100 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Smoking
Interventions: Switch to smoking only little cigars; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 65 Years
Enrollment: 197 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Non-menthol Cigarette Smoking, Menthol Cigarette Smoking, Synthetic Cooling Agent Cigarette Smoking, Usual Brand Cigarette Smoking, Spirometry, Questionnaire Administration, Nasal Epithelial Lining Fluid; Behavioral · Diagnostic Test · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 29 Years
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Vaping
Interventions: Expert, one-sided, Expert, two-sided, Peer, one-sided, Peer, two-sided; Other
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years to 24 Years
Enrollment: 848 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Cough
Interventions: electronic cigarette exposure; Device
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Cigarette Smoking, Nicotine Dependence
Interventions: varenicline (Chantix), bupropion (Zyban), nicotine patches; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 2
States / cities: Durham, North Carolina • Raleigh, North Carolina

Conditions: Cigarette Smoking
Interventions: Mood Management Phone Counseling for Smoking Cessation; Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 53 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Cardiovascular Risk Factor, Nicotine Dependence
Interventions: Low Nicotine E-Liquid, Medium or High Nicotine E-Liquid; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Smoking, Tobacco Use, Tobacco Smoking
Interventions: Product A: Non-Combusted Cigarette Variant 42001402 and product use Mode B, Product B: Non-Combusted Cigarette Variant 42001399 and product use Mode B, Product C: Non-Combusted Cigarette Variant 42001401 and product use Mode B, Product D: Non-Combusted Cigarette Variant 40007386 and product use Mode B, Product E: Non-Combusted Cigarette Variant 42001402 and product use Mode A; Other
Lead sponsor: British American Tobacco (Investments) Limited; Industry
Eligibility: 26 Years to 55 Years
Enrollment: 806 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 18
States / cities: Bentonville, Arkansas • Little Rock, Arkansas • Rogers, Arkansas + 14 more

Conditions: Electronic Cigarette Related Lung Damage
Interventions: Hyperpolarized xenon 129, Cardiopulmonary Stress Test, Pulmonary Function Test, Chest CT; Drug · Diagnostic Test
Lead sponsor: Y. Michael Shim, MD; Other
Eligibility: 18 Years to 35 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2032
U.S. locations: 2
States / cities: Durham, North Carolina • Charlottesville, Virginia

Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: Non-interventional study.; Other
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 40 Years and older
Enrollment: 1,283 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007
U.S. locations: 47
States / cities: Highlands Ranch, Colorado • Wheat Ridge, Colorado • Clearwater, Florida + 43 more

Conditions: Smoking, Smoking, Cigarette, E-Cig Use, Nicotine Dependence
Interventions: very low nicotine content cigarettes, normal nicotine content cigarettes, Study e-cigarette; Other
Lead sponsor: Duke University; Other
Eligibility: 21 Years and older
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking
Interventions: Cigarette, Hookah; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 65 Years
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Smoking Cessation, Weight Gain
Interventions: Exenatide 2 milligram (mg) Injection, Placebo, Nicotine patch, Smoking Cessation Counseling; Drug · Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 75 Years
Enrollment: 140 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 2
States / cities: Houston, Texas

Conditions: HIV, Alcohol, Smoking Cigarette, Cardiovascular Disease Prevention
Interventions: Semaglutide (Rybelsus®), Placebo; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years to 89 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Cigarette Smoking
Interventions: Not listed
Lead sponsor: R.J. Reynolds Tobacco Company; Industry
Eligibility: 35 Years to 60 Years · Male only
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: High Point, North Carolina

Conditions: Smoking, Tobacco
Interventions: MASP app + NRT, QuitGuide app + NRT; Other
Lead sponsor: University of Houston; Other
Eligibility: 18 Years and older
Enrollment: 227 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 2
States / cities: Oklahoma City, Oklahoma • Houston, Texas

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Smartphone App-delivered Smoking Cessation Intervention, Health Promotion and Education, Biospecimen Collection, Questionnaire Administration; Behavioral · Other
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years to 30 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Nicotine Dependence
Interventions: Dual nicotine patch and electronic cigarette; Other
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 45 Years
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2027
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Smoking, Pain, Smoking Cessation
Interventions: Smoking Cessation plus CBI, Smoking Cessation Standard; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 371 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 2
States / cities: West Haven, Connecticut • Leeds, Massachusetts

Conditions: Smoking
Interventions: Own Brand Menthol Cigarette, Electronic Menthol Cigarette #1, Electronic Menthol Cigarette #2, Electronic Menthol Cigarette #3, Leading U.S. Nicotine Gum; Other
Lead sponsor: R.J. Reynolds Vapor Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 71 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016
U.S. locations: 1
States / cities: Lincoln, Nebraska

Conditions: Cigarette Smoking
Interventions: Yohimbine Hydrochloride, Hydrocortisone, Lactose Monohydrate Powder; Drug
Lead sponsor: Wayne State University; Other
Eligibility: 21 Years to 35 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Nicotine Dependence
Interventions: Ad Libitum Use followed by Instructed Use of the Inspire Device, Instructed Use followed by Ad Libitum Use of the Inspire Device, Smart-T Smoking Cessation App with the Inspire Device Condition, Smart-T Smoking Cessation App Without the Inspire Device Condition, Nicotine replacement therapy (NRT), Inspire Device; Device · Drug
Lead sponsor: University of Houston; Other
Eligibility: 18 Years and older
Enrollment: 132 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Search by objective public record fields.

Post-Market Surveillance of Tobacco Products

ACT Lung Health Intervention: Phase Two

Nicotine Metabolism and Little Cigars

Evaluating the Impact of Synthetic Cooling Agents in Combustible Cigarettes on Smoking Perceptions and Use

Responses to E-cigarette Message Source and Presentation

Effect of Electronic Cigarette Use on Cough Reflex Sensitivity

Tailored Smoking Cessation Treatment for LIVE FOR LIFE® Participants

Mood Management Phone Counseling in Smoking Cessation

Vaping High vs. Low Nicotine E-Liquid

BAT3221032: A Study to Evaluate the Effects of Switching From Cigarette Smoking to Using One of Five Variants of a Heated Tobacco Product on Biomarkers of Exposure and Biomarkers of Potential Harm in Healthy Subjects

Dissolved Phase HXe-129 MRI: A Novel Biomarker to Quantify Pulmonary Pathology

Airway Limitation Study: Study In Primary Care Centers Of Chronic Bronchitis In Long-Term Cigarette Smokers Of At Least 40 Years Of Age With Symptoms Of Cough And Shortness Of Breath

Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2

Comparison of Hookah and Cigarette Smoking

Exenatide for Smoking Cessation and Prevention of Weight Gain

GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV

Development of Biomarkers of Effect From Chronic Tobacco Usage

Smoking, Stress, and Mobile Technology

EQQUAL-NM for the Promotion of Smoking Cessation in Sexual and Gender Minority Young Adults in New Mexico

Electronic Cigarettes and Reactivity to Smoking Cues

Pain and Smoking Study

Comparison of Nicotine Plasma Concentrations and Subjective Effects for Three Menthol Electronic Cigarettes vs Combustible Menthol Cigarettes and Nicotine Gum

Investigation of Nicotine Seeking Behavior in Current Smokers

Smart Olfaction App to Reduce Relapse