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ClinicalTrials.gov public records Last synced Nov 15, 2026, 10:04 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 385–408 of 798 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking Cigarette Clear all

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Informational Intervention, Media Intervention, Questionnaire Administration, Smoking Cessation Intervention, Survey Administration, Telephone-Based Intervention, Tobacco Cessation Counseling; Other · Behavioral
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 191 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)
Interventions: Acute (24-hour) abstinence, Ad libitum smoking/vaping; Behavioral
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 21 Years to 50 Years
Enrollment: 370 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Cigarette Smoking, Tobacco Smoking
Interventions: Unfiltered Cigarettes, Filtered Cigarettes; Other
Lead sponsor: San Diego State University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 37 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: San Marcos, California

Conditions: Nicotine Dependence
Interventions: Varenicline, Bupropion, Nicotine patches, Nicotine Inhaler; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 702 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 4
States / cities: Charlotte, North Carolina • Durham, North Carolina • Raleigh, North Carolina + 1 more

Conditions: Nicotine Dependence, Electronic Cigarette Use
Interventions: Electronic Cigarette, Nicotine Lozenge; Drug
Lead sponsor: Butler Hospital; Other
Eligibility: 21 Years to 65 Years
Enrollment: 183 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Nicotine Dependence, Schizophrenia
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 55 Years
Enrollment: 62 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Catonsville, Maryland

Conditions: HIV/AIDS, Nicotine Dependence
Interventions: Varenicline, Nicotine patch, Standard treatment, Standard treatment + Managed Problem Solving (MAPS) adherence intervention; Drug · Behavioral
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 18 Years and older
Enrollment: 340 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 2
States / cities: Chicago, Illinois • Philadelphia, Pennsylvania

Conditions: Vaping, Underage
Interventions: IKE System; Other
Lead sponsor: IKE Tech; Industry
Eligibility: 18 Years and older
Enrollment: 102 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 4
States / cities: Los Angeles, California • Chicago, Illinois • New York, New York + 1 more

Conditions: Smoking
Interventions: UCSF/SFGH Internet Stop Smoking Study site; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 18,154 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use Disorder
Interventions: computer-assisted smoking cessation intervention, cancer prevention, educational intervention, survey administration; Behavioral · Other
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 630 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2009
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Smoking
Interventions: Low level nicotine cigarette, Intermediate nicotine level cigarette, High level nicotine cigarette; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 64 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Tobacco Use Disorder, Dual Tobacco Use, Tobacco Dependence, Smoking, Smoking, Cigar, Smoking, Cigarette, Smoking, Tobacco
Interventions: Flavored and unflavored little cigars/cigarillos (LCCs); Other
Lead sponsor: UConn Health; Other
Eligibility: 18 Years to 34 Years
Enrollment: 65 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Tobacco Use, Smoking, Tobacco Smoking
Interventions: Marlboro Gold Box, Newport Box, Non-combusted cigarette variant 42001401, Non-combusted cigarette variant 42001399, Non-combusted cigarette variant 40007386, Non-combusted cigarette variant 42001402; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years and older
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: Stockbridge, Georgia

Conditions: Schizophrenia, Tobacco Use Disorder, Nicotine Dependance
Interventions: Varenicline; Drug
Lead sponsor: Nathan Kline Institute for Psychiatric Research; Other
Eligibility: 18 Years to 65 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Lung Non-Small Cell Carcinoma, Head and Neck Squamous Cell Carcinoma
Interventions: Nicotine Replacement, Bupropion Hydrochloride Controlled-release, Varenicline, Tobacco Cessation Counseling, Questionnaire Administration, Quality of Life Assessment, Best Practice; Drug · Other
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking Cessation, Smoking, Smoking Reduction, Smoking, Cigarette, Smoking (Tobacco) Addiction, Smoking Habit
Interventions: Guided Imagery Intervention, Standard Behavioral Control; Other
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years and older
Enrollment: 1,209 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Smoking, E-Cig Use, Oncology
Interventions: Harm Reduction (E-cigarette switching), Standard of Care; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 208 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Electronic Cigarettes
Interventions: e-Cigarette; Other
Lead sponsor: University of Southern California; Other
Eligibility: 21 Years and older
Enrollment: 37 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Tobacco Use Disorder
Interventions: Varenicline, Placebo pill; Drug
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years to 64 Years
Enrollment: 73 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Smoking, Tobacco Smoking
Interventions: Effect of Packaging on Smoking Perceptions and Behavior; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 21 Years to 65 Years
Enrollment: 359 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Tobacco Use Disorder, Smoking
Interventions: e-cigarettes; Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 21 Years to 35 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Tobacco Use Disorder
Interventions: E-cigarette product; Device
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 21 Years and older
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Lung Cancer Screening, Lung Neoplasms, Smoking ( Cigarette), Early Detection of Cancer
Interventions: Empower LCS, Call+ Telephone Navigation, Usual Care, Education; Behavioral · Other
Lead sponsor: University of California, Irvine; Other
Eligibility: 50 Years to 80 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 57
States / cities: Anaheim, California • Costa Mesa, California • Irvine, California + 27 more

Conditions: Cigarette Smoking
Interventions: Not-On-Tobacco smoking cessation program; Behavioral
Lead sponsor: Nationwide Children's Hospital; Other
Eligibility: 13 Years to 19 Years
Enrollment: 147 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Columbus, Ohio

Search by objective public record fields.

Increasing Access to Smoking Cessation and Smoke Free Home Services for Low-Income Pregnant Women in Northeast Texas

Vaping and Smoking Withdrawal Project

A Study of Unfiltered Cigarettes Among Committed Smokers

Concurrent Bupropion / Varenicline for Smoking Cessation

Methadone-Maintained Smokers Switching to E-Cigarettes

Effects of Nicotine on Areas of Impaired and Preserved Functioning in Schizophrenia

Optimizing Tobacco Use Treatment for PLWHA

Human Factors Validation and Usability Testing of the IKE Age-Gating System

Internet Stop Smoking Study - Phase VI

Computer-Assisted Stop-Smoking Program in Helping Doctors Counsel Patients Who Smoke Cigarettes

Palatability of Experimental Cigarettes - Study 2

Addictive Potential of LCCs in Dual Users

CSD200902: Assessment of Indoor Air Quality for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Environmental Testing Chamber

Varenicline Effects In Schizophrenic Smokers

Effectiveness of an Enhanced Tobacco Intervention Protocol Compared to Standard Treatment in Helping Head and Neck and Lung Cancer Patients Starting Treatment to Reduce Cigarette Use

Testing the Efficacy of A Scalable, Telephone-Delivered, Guided Imagery Tobacco Cessation Intervention

Clinical Alternatives for Reducing Harm Using E-cigarettes

Effects of e-Cigarettes on Nicotine Withdrawal

Varenicline-Aided Cigarette Reduction in Smokers Not Ready to Quit

Effect of Packaging on Smoking Perceptions and Behavior

Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy

Comparative Acceptability of Tobacco and Menthol Flavored E-cigarettes

Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)

Predictors of Teen Smoking-cessation