Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:01 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 433–456 of 798 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking Cigarette Clear all

Conditions: Smoking, Tobacco Use
Interventions: Salt Base Nicotine, Free Base Nicotine; Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Tobacco Use Disorder
Interventions: Very low nicotine content cigarettes; Other
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years to 70 Years
Enrollment: 775 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 2
States / cities: Baltimore, Maryland • Burlington, Vermont

Conditions: Cigarette Smoking Toxicity
Interventions: Menthol to non-menthol; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 65 Years
Enrollment: 87 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema, Asthma-COPD Overlap Syndrome
Interventions: E-Cigarette, Financial Incentives; Other · Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 40 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Cigarette Smoking
Interventions: refresh; Behavioral
Lead sponsor: Pro-Change Behavior Systems; Other
Eligibility: 18 Years and older
Enrollment: 51 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: South Kingstown, Rhode Island

Conditions: Nicotine Dependence
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 60 Years
Enrollment: 159 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2013
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Behavior, Addictive, Cigarette Smoking
Interventions: self-control practice; Behavioral
Lead sponsor: University at Albany; Other
Eligibility: 18 Years to 45 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2009
U.S. locations: 1
States / cities: Albany, New York

Conditions: Nicotine Administration & Dosage, E-cigarettes, Vaping, E-Liquid, Tobacco Smoking
Interventions: JUUL, Tobacco; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Cigarette Smoking-Related Carcinoma, Lung Carcinoma
Interventions: Discussion, Media Intervention, Interview, Test; Procedure · Other
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years and older
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking Cessation, Smoking Reduction, Cancer
Interventions: High-level construal, Down-regulation of craving for cigarettes, Up-regulation of goal energization; Behavioral
Lead sponsor: University of Oregon; Other
Eligibility: 25 Years to 55 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 2
States / cities: Eugene, Oregon

Conditions: Cigarette Smoking, Schizophrenia, Bipolar Disorder, Depressive Disorder, Major, Smoking Cessation
Interventions: Academic Detailing, Community Health Worker, Treatment as Usual (TAU); Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 1,165 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking
Interventions: THS 2.2, CC; Other
Lead sponsor: Philip Morris Products S.A.; Industry
Eligibility: 30 Years and older
Enrollment: 672 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 19
States / cities: Tempe, Arizona • Clearwater, Florida • Daytona Beach, Florida + 16 more

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Biospecimen Collection, Broccoli Sprout/Broccoli Seed Extract Supplement, Placebo Administration, Questionnaire Administration; Procedure · Dietary Supplement · Drug + 1 more
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 18 Years and older
Enrollment: 135 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 3
States / cities: Tucson, Arizona • Washington D.C., District of Columbia • Buffalo, New York

Conditions: Tobacco Use Disorder
Interventions: Very low nicotine content cigarettes; Other
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years to 44 Years · Female only
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 2
States / cities: Lexington, Kentucky • Burlington, Vermont

Conditions: Smoking, Stress Disorders, Post-Traumatic
Interventions: Smoking Cessation Cognitive Behavioral Therapy (CBT), Bupropion, Cognitive Processing Therapy, Smoking Abstinence Reinforcement Therapy, Yoked Contingency Management; Behavioral · Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 80 Years
Enrollment: 115 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Cigarette Smoking
Interventions: nicotine polacrilex, transdermal system or inhaler; Drug
Lead sponsor: University of Nebraska; Other
Eligibility: 19 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Tobacco Use
Interventions: Ventilated Cigarette Filter, Unventilated Cigarette Filter; Other
Lead sponsor: Masonic Cancer Center, University of Minnesota; Other
Eligibility: 21 Years and older
Enrollment: 164 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 2
States / cities: Minneapolis, Minnesota • Columbus, Ohio

Conditions: Smoking
Interventions: Breath Sample, Saliva Sample, Questionnaire, View Virtual Reality Scenes; Other · Behavioral
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking, Smoking Cessation, Smoking Reduction
Interventions: Progesterone 200 MG Oral Capsule; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 171 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Cigarette Smoking, Nicotine Vaping
Interventions: All nicotine/ tobacco products at market price, Nicotine vaping products at 1/2 market price, Heated tobacco products at 1/2 market price., Nicotine pouch products at 1/2 market price.; Other
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 440 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Cigarette Smoking, Post Traumatic Stress Disorder, Signs and Symptoms, Respiratory
Interventions: CBT-A, CBT-S; Behavioral
Lead sponsor: Stony Brook University; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Stony Brook, New York

Conditions: Opioid-use Disorder, Acceptability of Health Care, Opioid-Related Disorders
Interventions: Not listed
Lead sponsor: Cambridge Health Alliance; Other
Eligibility: 18 Years and older
Enrollment: 817 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Cambridge, Massachusetts

Conditions: Smoking Cessation
Interventions: Naltrexone (Vivitrol), Bupropion; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cigarette Smoking
Interventions: Standard Treatment, Behavioral Activation Treatment for Smoking, Transdermal Nicotine Patch; Behavioral · Drug
Lead sponsor: University of Maryland, College Park; Other
Eligibility: 18 Years to 65 Years
Enrollment: 184 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2016
U.S. locations: 1
States / cities: College Park, Maryland

Search by objective public record fields.

Salt-Based E-cigarette

Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers

Smoking Topography and Harm Exposure in Menthol Cigarettes

Pulmonary and Cardiac Effects of E-Cigarette Use in Pulmonary Patients Who Smoke Cigarettes

Health-Kit Enabled Mobile App for Tobacco Cessation

Multimodal Neuroimaging Genetic Biomarkers of Nicotine AddictionSeverity

Practicing Self-Control Lowers the Risk of Smoking Lapse

Evaluating the Comparative Pharmacokinetics of Nicotine After Administration Via JUUL or Tobacco Cigarettes

Culturally Tailored Educational Video to Promote Lung Cancer Screening in Vulnerable Communities

Construal Level as a Novel Pathway for Affect Regulation and Cancer Control

Integrated Smoking Cessation Treatment for Smokers With Serious Mental Illness

A 26-week Extension of the ZRHR-ERS-09-US Study Evaluating Biological and Functional Changes in Healthy Smokers After Switching to THS 2.2

Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers

Project 4, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Pregnant Women

CPT-SMART for Treatment of PTSD and Cigarette Smoking

Analysis of Lipid Biomarkers of Exposure and Host Response

Telehealth-Filter Ventilation ( COMET2P1 )

Cue Reactivity in Virtual Reality: The Role of Context

Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children

Examining the Generality of Laboratory-based Findings and Their Moderators in the ITC Study

Enhanced Smoking Cessation Intervention for Smokers Exposed to the World Trade Center (WTC) Disaster

Patients' Attitudes Toward and Experiences With Buprenorphine Treatment

Study of Injectable Naltrexone and Oral Bupropion Among Cigarette Smokers With Schizophrenia

Behavioral Activation Intervention for Smoking Cessation in Smokers With Depressive Symptoms