Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:33 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 481–504 of 798 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking Cigarette Clear all

Conditions: Smoking, Tobacco Use
Interventions: Pod System E-cig, Customizable Tank E-cig, Control; Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Nicotine Addiction, Drug Addiction, Drug Dependence, Substance Use Disorder, Tobacco Dependence
Interventions: Mobile Smoking Cessation Solution; Device
Lead sponsor: Click Therapeutics, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 416 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Cigarette Smoking
Interventions: Resistance training, Health and Wellness; Behavioral
Lead sponsor: Teachers College, Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Smoking, Nicotine Dependence
Interventions: Naltrexone, Varenicline; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cigarette Smoking
Interventions: Moderate intensity exercise, Health education; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 55 Years · Female only
Enrollment: 113 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: E-Cig Use, Adolescent Behavior
Interventions: Peer-Led Peer-Elected Intervention, Adult-Led Intervention, Peer-Led Non-Elected Intervention; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: Not listed
Enrollment: 686 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Cigarette Smoking, Smoking Behaviors, Treatment
Interventions: Switching to a different medication, Continued use of the same medication, Switching to a harm reduction tobacco product; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 544 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Electronic Cigarette Use
Interventions: RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, RELX ENDS Tobacco and Menthol Flavors; Other
Lead sponsor: Cheerain HK Limited; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 194 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 5
States / cities: Bentonville, Arkansas • Lexington, Kentucky • Springfield, Missouri + 2 more

Conditions: Nicotine Addiction
Interventions: Not listed
Lead sponsor: Rochester Institute of Technology; Other
Eligibility: 21 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Smoking
Interventions: FT21039, FT21041, FT21044, FT21042; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 144 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 2
States / cities: Neptune City, New Jersey • High Point, North Carolina

Conditions: Cigarette Smoking, Tobacco Use, Cigarette Smoking Behavior
Interventions: HRP Sampling period, NPL Sampling period; Other
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 21 Years and older
Enrollment: 472 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Nicotine
Interventions: Not listed
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 50 Years
Enrollment: 54 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2017
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking, Cigarette
Interventions: Low Nicotine Content Cigarettes, Control message, Test message; Drug · Other
Lead sponsor: Masonic Cancer Center, University of Minnesota; Other
Eligibility: 21 Years and older
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Efficacy of Financial Incentives
Interventions: Voucher-based incentives; Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 166 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Electronic Cigarette Use
Interventions: Low strength nicotine e-liquid, High strength nicotine e-liquid; Drug
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 55 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Use Disorder/Cigarette Smoking, HIV
Interventions: nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster; Drug · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 794 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2031
U.S. locations: 5
States / cities: Bridgeport, Connecticut • New Haven, Connecticut • Jersey City, New Jersey + 2 more

Conditions: Smoking Cessation
Interventions: Enhanced E-cigarette Coaching, Quitline treatment as usual; Behavioral
Lead sponsor: Consumer Wellness Solutions; Industry
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Cigarette Smoking
Interventions: Mindfulness-based Addiction Treatment, iQuit Mindfully, Self-Help guide, Nicotine Patch; Behavioral · Drug
Lead sponsor: Georgia State University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Cigarette Smoking
Interventions: Puff Topography Biofeedback Training, Control; Behavioral
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 19 Years to 55 Years
Enrollment: 154 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Smoking
Interventions: Quit smoking, Nicotine patch, Placebo Patch; Behavioral · Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 147 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Vaping, E-Cig Use
Interventions: cytisinicline, Placebo, Behavioral support; Drug · Behavioral
Lead sponsor: Achieve Life Sciences; Industry
Eligibility: 18 Years and older
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 5
States / cities: Lexington, Kentucky • Boston, Massachusetts • Rochester, New York + 2 more

Conditions: Cigarette Smoking
Interventions: Smoking cessation guideline implementation; Behavioral
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years and older
Enrollment: 789 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 2
States / cities: Des Moines, Iowa • Iowa City, Iowa

Conditions: Smoking
Interventions: Leading U.S. non-menthol cigarette, Leading U.S. menthol cigarette, Electronic cigarette #1, Electronic cigarette #2, Electronic cigarette #3, U.S. Market-sample electronic cigarettes; Other
Lead sponsor: R.J. Reynolds Vapor Company; Industry
Eligibility: 21 Years to 99 Years
Enrollment: 71 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Stockbridge, Georgia

Conditions: Breast Cancer, Tobacco Dependence
Interventions: placebo, varenicline; Drug
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: New York, New York

Search by objective public record fields.

JUUL vs. Mod E-cigarette Study

Clinical Trial of Smoking Cessation Mobile Phone Program

Resistance Training as an Aid to Smoking Cessation Treatment

Naltrexone and Varenicline: Weight Gain and Tolerability in Cigarette Smokers

Quit Smoking With Nicotine Patch and Exercise/Health Education (Females Only)

Identifying Student Opinion Leaders to Lead E-cigarette Interventions

A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse

Characterization of Product Use in Smokers Switching From Cigarettes to a RELX Electronic Nicotine Delivery System

Developing Evidence to Inform Regulatory Policy on Nicotine Content in E-Liquids

CSD170301: An Unblinded, Parallel, Randomized Study to Assess Nicotine Uptake in Smokers From Four Different Electronic Cigarettes

Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

Nicotine and Brain Imaging Research Study

Impact of Low Nicotine Cigarette Messaging on Perceptions and Cigarette Choices

Voucher Based Incentives to Treat Pregnant Smokers

Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors

Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial

Enhanced E-cigarette Coaching Intervention for Dual Users of Cigarettes and E-cigarettes

iQuit Mindfully: Text Messaging for Smoking Cessation

Puff Biofeedback to Reduce Smoking Reinforcement

Neurobiology of Nicotine and Non-nicotine Components of Tobacco Addiction

A Study of Cytisinicline for Vaping Cessation in Adult Smokers

The Effectiveness of Smoking Cessation Guidelines in the Emergency Department

Evaluation of Environmental Emissions From Electronic Cigarettes and Tobacco-Burning Cigarettes

Tobacco Dependence in Breast Cancer Patients Trial of Varenicline (Chantix)