Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:42 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 505–528 of 798 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking Cigarette Clear all

Conditions: Cigarette Smoking
Interventions: Propranolol, Placebo; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Behavior, Health Risk, Implementation Science, E Cigarette Use, Cessation, Smoking, Incentives, Engagement, Patient, Peer Support, Media Literacy
Interventions: Text-massaging suport, Financial incentive, Media literacy; Behavioral
Lead sponsor: University of Nebraska; Other
Eligibility: 19 Years to 29 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Electronic Cigarette Use
Interventions: Cigarette Smoker/ECIG users: 0 mg/ml nicotine concentration, Cigarette Smokers/ECIG users: 6 mg/ml nicotine concentration, Cigarette Smokers/ECIG users: 15 mg/ml nicotine concentration, Cigarette Smokers/ECIG users: 30 mg/ml nicotine concentration; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Addiction Nicotine
Interventions: VapeAway filter system; Device
Lead sponsor: VapeAway; Industry
Eligibility: 21 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Tobacco Use, Tobacco Smoking, Tobacco Use Cessation, Tobacco Use Disorder, Schizophrenia, Schizoaffective Disorder
Interventions: Persistence Targeted Smoking Cessation in SMI (PTSC-S), Nicotine patch; Behavioral · Drug
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years to 70 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Cigarette Smoking, Hypertension
Interventions: Varenicline, behavioral therapy; Drug · Behavioral
Lead sponsor: UConn Health; Other
Eligibility: 18 Years and older
Enrollment: 203 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Tobacco Use Disorder, Smoking
Interventions: Ariva® Silver Wintergreen, Silver Wintergreen; Other
Lead sponsor: Star Scientific, Inc; Industry
Eligibility: 23 Years to 72 Years
Enrollment: 111 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010
U.S. locations: 1
States / cities: Martinsburg, West Virginia

Conditions: Smoking
Interventions: smokeSCREEN game; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 10 Years to 16 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 4
States / cities: Hamden, Connecticut • New Haven, Connecticut

Conditions: Smoking Cessation, Obesity and Obesity-related Medical Conditions
Interventions: Electronic Cigarettes (EC), Nicotine replacement therapy (NRT); Other
Lead sponsor: Brown University; Other
Eligibility: 21 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Tobacco Use
Interventions: Not listed
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 50 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Cigarette Smoking-Related Carcinoma, Malignant Thoracic Neoplasm
Interventions: Electronic Health Record Review, Informational Intervention, Interview, Referral, Smoking Cessation Intervention, Survey Administration; Other · Device
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years and older
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Nicotine Addiction, Drug Addiction, Drug Dependence, Substance Use Disorder, Tobacco Dependence
Interventions: Treatment A with device Clickotine® (Active intervention), Treatment B with smoking education (control); Device
Lead sponsor: Click Therapeutics, Inc.; Industry
Eligibility: 18 Years to 65 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: New York, New York

Conditions: Nicotine Dependence
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 64 Years
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cigarette Smoking
Interventions: Smoking research cigarettes with or without NRT; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Cigarette Smoking
Interventions: Nicotine Patch; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 479 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Cigarette Smoking
Interventions: Contingency Management, Standard of Care; Behavioral · Other
Lead sponsor: UConn Health; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: New Britain, Connecticut

Conditions: Smoking, Nicotine Dependence
Interventions: No intervention: observation only; Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 99 Years
Enrollment: 422 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2019
U.S. locations: 2
States / cities: Madison, Wisconsin • Milwaukee, Wisconsin

Conditions: Nicotine Dependence, Cigarette Smoking, Alcohol Consumption, Heavy Drinking
Interventions: Varenicline; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: HIV, Emphysema, HIV Infections
Interventions: Not listed
Lead sponsor: Philip Diaz; Other
Eligibility: 18 Years and older
Enrollment: 365 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Cigarette Smoker, Current Every Day Smoker
Interventions: Bronchoscopy with Bronchoalveolar Lavage, Cigarette, Electronic Cigarette, Laboratory Biomarker Analysis, Nicotine Replacement, Questionnaire Administration; Procedure · Drug · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 52 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma
Interventions: Cigarette, Nicotine Replacement, Questionnaire Administration, Survey Administration, Very Low Nicotine Content Cigarette, ECIG-Hi, ECIG-Lo; Drug · Other · Device
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 21 Years to 65 Years
Enrollment: 213 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Online Smoking Cessation Intervention, Questionnaire Administration, Health Promotion and Education; Behavioral · Other
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years to 30 Years
Enrollment: 125 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
Interventions: Non-combusted cigarette variant 42001401, Non-combusted cigarette variant 42001399, Non-combusted cigarette variant 40007386, Non-combusted cigarette variant 42001402; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years and older
Enrollment: 194 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 7
States / cities: Sandy Springs, Georgia • Lexington, Kentucky • Charlotte, North Carolina + 4 more

Conditions: Cigarette Smoking, Nicotine Dependence, Nicotine Withdrawal
Interventions: Smoking Abstinence, Ad Lib Smoking; Other
Lead sponsor: University of Oklahoma; Other
Eligibility: 21 Years to 55 Years
Enrollment: 58 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Search by objective public record fields.

Neurobehavioral Substrates of Propranolol's Effects on Drug Cue Reactivity

Incentive-based and Media Literacy Informed Approaches to Improve Vaping Cessation

Assessing Electronic Cigarette Nicotine Flux

The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction

Persistence Targeted Smoking Cessation in Serious Mental Illness (SMI)

Smoking Study With Behavioral Therapy for Hypertensive Patients

Pilot Study to Evaluate the Safety and Efficacy of Ariva® Silver Wintergreen in Reducing Cigarette Craving in Smokers

Development of a Videogame Prototype Targeting Cigarette and Marijuana Smoking, and Tobacco Product Prevention Among Young Adolescents

Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy

E-Cigarette and Cigarette Nicotine Delivery and Abuse Liability in Cigarette Smokers and Dual Users

A Novel Tobacco Cessation Resource for Smokers With a Diagnosed or Suspected Thoracic Cancer

Clinical Trial of an Innovative Digital Therapeutic for Smoking Cessation With Biochemical Verification

Breath Carbon Monoxide and Cotinine as Biomarkers to Distinguish Smokers From Nonsmokers

Project 1, Study 2: The Combined Impact of Nicotine Replacement and Spectrum Cigarettes

Concurrent Nicotine Patch / Denicotinized Cigarette Therapy for Smoking Cessation II

Contingency Management for Smoking Cessation in the Homeless

E-Cigarettes: Dynamic Patterns of Use and Health Effects

New Approaches to Smoking Cessation in Heavy Drinkers

Alveolar Macrophage Proteomics in HIV-associated Emphysema

Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs

Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers

Avatar-Led Digital Therapeutic for Aiding Smoking Cessation in Sexual and Gender Minority Young Adults

CSD210903: A Study to Determine Subject Puffing Patterns of a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Ambulatory Setting

Nicotine Withdrawal and Reward Processing