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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:39 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 553–576 of 798 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking Cigarette Clear all

Conditions: Electronic Cigarette Use
Interventions: Preferred ENDS, Preferred ENDS with HWL; Other
Lead sponsor: Florida International University; Other
Eligibility: 21 Years to 35 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Miami, Florida

Conditions: E-cigarette, Vaping, Tobacco, Nicotine, Adolescent Behavior, Video Information, Digital Education Interventions
Interventions: Working group, Focus group; Other
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 13 Years and older
Enrollment: 46 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking Cessation
Interventions: Motivational Interviewing (MI), Structured Brief Advice (SBA); Behavioral
Lead sponsor: Pennsylvania Department of Health; Government
Eligibility: 14 Years to 18 Years
Enrollment: 330 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 3
States / cities: Allentown, Pennsylvania • Philadelphia, Pennsylvania • Pittsburgh, Pennsylvania

Conditions: Tobacco Use Disorder
Interventions: AZD8529; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 75 Years · Female only
Enrollment: 214 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 9
States / cities: Encino, California • La Jolla, California • Los Alamitos, California + 6 more

Conditions: Electronic Cigarette Use
Interventions: Tobacco product administration and assessment, own brand cigarettes, Tobacco product administration and assessment, ECIG 30 Watts, 0 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 8 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 15 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 30 mg/ml nicotine; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Nicotine Dependence, Cigarettes
Interventions: Motivational Text Messages, Control; Behavioral
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 158 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Smoking Cessation, Electronic Cigarette Use, Cigarette Smoking
Interventions: Regular Nicotine patch and lozenge dose, Augmented Nicotine patch and lozenge dose; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Cigarette Smoking, Nicotine Withdrawal
Interventions: Smoking Abstinence, Ad Lib Smoking; Other
Lead sponsor: Duke University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Cessation, Smoking (Tobacco) Addiction
Interventions: chatbot, no chatbot; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 21 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Cigarette Smoking
Interventions: Nicotine Patch, Varenicline, Placebo Nicotine Patch, Placebo Capsule; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 125 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking, Cigarette Smoking
Interventions: Helpers Stay Quit Training; Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 99 Years
Enrollment: 940 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: E-cigarette Use
Interventions: E-cigarette cessation text-messaging intervention, Standard care control using standard national resources; Behavioral
Lead sponsor: Jovan Gwon, PhD, RN, FIAAN; Other
Eligibility: 18 Years to 24 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Cigarette Smoking
Interventions: Bundle-size 1, Bundle-size 3, Bundle-size 9; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 308 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Carbon Monoxide Measurement, Nicotine Oral Pouch, Questionnaire Administration, Smoke usual brand cigarette; Procedure · Drug · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Cigarette Smoker
Interventions: nicotine polacrilex, nicotine transdermal system, nicotine inhaler; Drug
Lead sponsor: University of Nebraska; Other
Eligibility: 19 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Smoking
Interventions: PD21864AA, PD21864AB; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years and older
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: Lakewood, Colorado

Conditions: Arterial Inflammation
Interventions: No drug or device, only a test. The test is called a PET/CT; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Smoking Cessation Intervention (New website), Smoking Cessation Intervention (Standard of care website), Health Education, Health Promotion and Education, Questionnaire Administration; Behavioral · Other
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 53 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Bedford, Massachusetts

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Non-Interventional Study; Other
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 18 Years to 30 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Smoking Behaviors
Interventions: Participants will place the pouch between their top lip and their gum for 30 minutes as per use instructions.; Drug
Lead sponsor: JT International SA; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 2
States / cities: Knoxville, Tennessee • San Antonio, Texas

Conditions: Transcranial Direct Current Stimulation, Smoking, Cigarette, Schizophrenia
Interventions: Transcranial Direct Current Stimulation, Cognitive Remediation (CR); Other · Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 65 Years
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Smoking
Interventions: Surgeon General's Warning, Graphic Warning; Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years and older
Enrollment: 2,149 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 2
States / cities: Oakland, California • Chapel Hill, North Carolina

Conditions: Cardiovascular Disease, Insulin Resistance
Interventions: Smoking cessation; Behavioral
Lead sponsor: Charles Drew University of Medicine and Science; Other
Eligibility: 25 Years to 70 Years
Enrollment: 103 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Tobacco Use, Substance Use Disorders
Interventions: Switching to E-Cigarette, Quitting using Medication, Counseling; Behavioral · Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 4
States / cities: Charleston, South Carolina • Conway, South Carolina • Greenville, South Carolina + 1 more

Search by objective public record fields.

Developing and Testing Health Warning Labels on the ENDS Device

Understanding Vape Marketing Study

Pennsylvania Adolescent Smoking Study (PASStudy)

The Study of AZD8529 for Smoking Cessation in Female Smokers

Effects of E-Cigarette Nicotine Content in Smokers (Nicotine Flux Study)

Penn State TXT2STAYQUIT Study- a Texting Study to Help Hospitalized Smokers Stay Quit

CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes

Nicotine Withdrawal and Reward Processing: Connecting Neurobiology to Real-world Behavior

PASCAL Feasibility Study

Effects of Smoking Environments on Craving and Smoking (CameraCue2.0)

Effect of Helpers Program On-line Training on Smoking Relapse and Social Networks

Vape-Free Text-Messaging: Pilot Study

Effects of Choice Bundling on Valuation of Delayed Gains and Losses in Cigarette Smokers

Studying Flavors and Cooling Agents in Oral Nicotine Pouches to Understand User Preferences

Validation of Biomarkers of Exposure and Host Response

CSD1602: A Crossover Study to Evaluate the Exposure to "Tar" and Nicotine From Two King Size Menthol Cigarette Products

Arterial Inflammation and E-Cigarettes

Website Smoking Cessation Intervention for the Promotion of Smoking Cessation in Low-Income Veterans

Understanding Tobacco and Cannabis Co-Use Practices: Initiation, Escalation, and Maintenance

Nicotine Pouch Pharmacokinetics Abuse Liability

tDCS and Cognitive Training Intervention for Chronic Smokers With Schizophrenia

Impact of Graphic Cigarette Warnings

Insulin Resistance in Smokers Undergoing Smoking Cessation

STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking