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ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:42 PM EST

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Showing 577–600 of 798 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking Cigarette Clear all

Conditions: Tobacco, Tobacco Abstinence, Smoking Cessation, Smoking Cessation; Tobacco Dependence, Human Immunodeficiency Virus (HIV), Tobacco Dependence Caused by Cigarettes, Cancer Prevention
Interventions: Learn to Quit-HIV (LTQ-H) App, QuitStart; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 314 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Tobacco Use, Nicotine Pouch Self-Administration
Interventions: Nicotine Pouch Dosage; Other
Lead sponsor: William Middleton; Other
Eligibility: 18 Years and older
Enrollment: 1,360 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Cigarette Smoking, E-Cigarette Use, Smoking Cessation
Interventions: Varenicline, Counseling, Guided Self-Change Booklets; Drug · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cigarette Smoker, Current Smoker, Former Smoker, Multiple Pulmonary Nodules, Pulmonary Nodule
Interventions: Computed Tomography, Fludeoxyglucose F-18, Fluorine F 18 L-glutamate Derivative BAY94-9392, Positron Emission Tomography (PET/CT); Diagnostic Test · Drug
Lead sponsor: Andrei Iagaru; Other
Eligibility: 45 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Cigarette Smoking, Nicotine Vaping
Interventions: All nicotine/ tobacco products at market price, Nicotine vaping products at 1/2 market price, Nicotine vaping products at 2x market price, Heated tobacco products at 1/2 market price., Heated tobacco products at 2x market price., Nicotine pouch products at 1/2 market price., Nicotine pouch products at 2x market price.; Other
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Smoking
Interventions: Usual Brand Cigarette, Electronic Cigarette #1, Electronic Cigarette #2, Leading U.S. Nicotine Gum; Other
Lead sponsor: R.J. Reynolds Vapor Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 153 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Cigarette Smoking, Schizophrenia
Interventions: Not listed
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 65 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 2
States / cities: Baltimore, Maryland

Conditions: Smoking, Healthy
Interventions: Cinnamaldehyde e-liquid, PG/VG e-liquid; Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 40 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Sedentary Lifestyle, Cigarette Smoking
Interventions: PA+ Smoking Cessation (LMPA), Standard Care Smoking Counseling (SCC); Behavioral
Lead sponsor: Temple University; Other
Eligibility: 18 Years to 59 Years
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Tobacco Use
Interventions: THC; Drug
Lead sponsor: Battelle Memorial Institute; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Nicotine Dependence
Interventions: nicotine, menthol; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 30 Years
Enrollment: 57 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 2
States / cities: West Haven, Connecticut

Conditions: Nicotine Dependence, Other Tobacco Product
Interventions: Nicotine, Low Dose Menthol, High Dose Menthol; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 20 Years
Enrollment: 59 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Stress, Smoking Cessation, Overeating
Interventions: Prompt to use smartphone apps for stress management; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Cigarette Smoking
Interventions: Nicotine patch; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 88 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Tobacco Smoking Behavior, Cigarette Smoking Behavior, Second Hand Tobacco Smoke, Tobacco Use Cessation
Interventions: Personalized Feedback; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 65 Years
Enrollment: 152 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Not listed
Lead sponsor: UConn Health; Other
Eligibility: 16 Years to 45 Years · Female only
Enrollment: 182 participants
Timeline: 2018 – 2023
U.S. locations: 6
States / cities: Denver, Colorado • Farmington, Connecticut • Hartford, Connecticut + 2 more

Conditions: Tobacco Use Disorder
Interventions: Nicotine Patch, VLNC Cigarette, VLNC Cigarette Plus Nicotine Patch; Drug · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 235 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2012
U.S. locations: 2
States / cities: Duluth, Minnesota • Minneapolis, Minnesota

Conditions: Electronic Cigarette Use
Interventions: Beverage with ethanol and E-cigarette liquid with ethanol, Beverage with ethanol and E-cigarette liquid without ethanol, Beverage without ethanol and E-cigarette liquid with ethanol, Beverage without ethanol and E-cigarette liquid without ethanol; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Tobacco Smoking, Psychiatric Disorders
Interventions: E-cigarette; Other
Lead sponsor: Fordham University; Other
Eligibility: 21 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Schizophrenia, Cigarette Smoking
Interventions: Nicotine replacement therapy, Bupropion, cognitive-behavioral smoking cessation counseling, Mobile Contingency Management, Stay Quit Coach, SMS text messaging; Drug · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Electronic Cigarette Use, Smoking, Cigarette, Nicotine Dependence
Interventions: NJOY ACE e-cigarette; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 50 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Lung Inflammation, HIV Seropositivity
Interventions: ECIGS, mobile contingency management (mCM), Usual brand; Other · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 64 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Electronic Cigarettes
Interventions: JUUL electronic cigarette, IQOS electronic cigarette, Own Brand cigarette; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Smoking Cessation
Interventions: Inserts with efficacy messages, Pictorial warnings on packs; Other
Lead sponsor: University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 387 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: Ithaca, New York • Columbia, South Carolina

Search by objective public record fields.

Quitting Matters Human Immunodeficiency Virus Hybrid Trial

Comparison of Demand and Substitution for Nicotine Pouches as a Function of Nicotine Dosage

Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use

18F-FSPG PET/CT in Diagnosing Early Lung Cancer in Patients With Lung Nodules

Comparison of the Substitution Between Different Tobacco/Nicotine Products as a Function of Tobacco-user Type

Assess Biomarkers of Tobacco Exposure and Nicotine Pharmacokinetics in Smokers After a 5-Day In-Clinic Confinement Switch to an Electronic Cigarette or Nicotine Gum

Knowledge and Perception of Smoking Risks/Consequences

In-vivo Effects of E-cigarette Aerosol on Innate Lung Host Defense

Step-up to Quit: Using Low-to-moderate Intensity Exercise for Reducing Smoking Cue Reactivity Among Low-income Smokers

A Laboratory Model of Increasing Delta-9-tetrahydrocannabinol (THC) Potency on Cigarette Smoking

The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users

Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 1

Sense2Stop:Mobile Sensor Data to Knowledge

Effects of Smoking Environments on Brain Reactivity

OCAST Cessation Study

Electronic Cigarette Use During Pregnancy

Innovative Interventions for Smoking Cessation

The Impact of Oral Ethanol and Vaped Ethanol on the Evaluation of Impairment

The Effect of Electronic Cigarette Use on Smoking Behaviors Among Smokers Receiving Outpatient Psychiatric Treatment

Mobile Health Technology to Enhance Abstinence in Smokers With Schizophrenia

Assessing E-Cigarettes for Tobacco Harm Reduction in the Context of Lung Cancer Screening

Effects of E-cigarettes (ECIGs) on Pulmonary Inflammation and Behavior in HIV Infected Smokers

Assessment of Two New Electronic Cigarettes in Cigarette Smokers

Cigarette Pack Inserts for Smoking Cessation