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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:13 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 145–168 of 798 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking Cigarette Clear all

Conditions: COPD (Chronic Obstructive Pulmonary Disease), Cancer Lung Screening, Smoking Cigarette
Interventions: Not listed
Lead sponsor: University of Michigan; Other
Eligibility: 50 Years to 80 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Smoking, Tobacco Use, Electronic Cigarette Use
Interventions: P1211216, P1213416, P1213716, P1213616, P1213816, P1211916, P1210016, P1211217, P1213417, P1211222, P1213422, P1213722, P1213622, P1213822, P1211922, P1210022; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years and older
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 4
States / cities: Stockbridge, Georgia • Lexington, Kentucky • Hickory, North Carolina + 1 more

Conditions: Tobacco Smoking, Healthy Participants, E-cigarette Smokers
Interventions: Felis Domesticus; Biological
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 50 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Tobacco Dependence
Interventions: Reduced Nicotine Content Cigarettes, Same Nicotine Content Cigarettes; Drug
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 280 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Hershey, Pennsylvania

Conditions: Cigarette Smoker, Current Every Day Smoker
Interventions: Informational Intervention, Telephone-Based Intervention; Other · Behavioral
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: Not listed
Enrollment: 46 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Electronic Cigarette Use
Interventions: Preferred Juul pod flavor (5% nicotine), Classic Tobacco Juul pod flavor (5% nicotine), Preferred flavor with HWL, Preferred flavor, 3% nicotine, Preferred flavor, 0% nicotine; Other
Lead sponsor: Florida International University; Other
Eligibility: 18 Years to 24 Years
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Nicotine Dependence, Major Depressive Disorder
Interventions: Varenicline, BASC, Standard treatment; Drug · Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 2
States / cities: Chicago, Illinois • Philadelphia, Pennsylvania

Conditions: Smoking Cessation, Cigarette Smoking, Schizophrenia, Psychotic Disorders, Major Depressive Disorder, Bipolar Disorder I, Bipolar II Disorder, Mental Illness
Interventions: Nicotine patch, Nicotine lozenge, Therapy, Information; Drug · Behavioral · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 65 Years
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Obesity, Smoking Cessation
Interventions: ENDS, CI, No ENDS, NI; Other
Lead sponsor: Brown University; Other
Eligibility: 21 Years to 99 Years
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Smoking, Cigarette, Smoking, Tobacco, Nicotine Dependence, Exposure to Toxic Agent
Interventions: Low wattage E cigarette device, High wattage E cigarette device, Usual brand cigarette; Behavioral
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 18 Years to 99 Years
Enrollment: 372 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Smoking, Cigarette
Interventions: Not listed
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 30 participants
Timeline: 2021
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Electronic Cigarette Use
Interventions: 5% nicotine (Partial Nicotine Reduction), 3% or 2.4% nicotine (Partial Nicotine Reduction), 5% nicotine (Total Nicotine Reduction), 0% nicotine (Total Nicotine Reduction); Other
Lead sponsor: Florida International University; Other
Eligibility: 21 Years to 35 Years
Enrollment: 116 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Smoking
Interventions: THS 2.2 Menthol (mTHS 2.2), Menthol Conventional Cigarette (mCC), Smoking Abstinence (SA); Other
Lead sponsor: Philip Morris Products S.A.; Industry
Eligibility: 22 Years and older
Enrollment: 160 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 2
States / cities: Daytona Beach, Florida • Dallas, Texas

Conditions: Electronic Cigarette Use, Cigarette Use, Electronic, Vaping, Cigarette Smoking
Interventions: E-cigarette e-liquid; Drug
Lead sponsor: University of Southern California; Other
Eligibility: 21 Years and older
Enrollment: 124 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Cigarette Smoking, Tobacco Smoking, Tobacco Use Disorder
Interventions: Sustained Care, Standard Care; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 1,359 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 3
States / cities: Boston, Massachusetts • Salem, Massachusetts • Pittsburgh, Pennsylvania

Conditions: Cigarette Smoking
Interventions: Extended Care Management, Standard Care; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 397 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Tobacco Use
Interventions: Cigarette Brand Switching, E-cigarette Flavor; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking, Tobacco Use
Interventions: IQOS; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Cigarette Smoking
Interventions: Low-nitrosamine smokefree tobacco product for oral use, Non-tobacco, non-nicotine placebo product; Drug · Other
Lead sponsor: Swedish Match AB; Industry
Eligibility: 25 Years to 65 Years
Enrollment: 250 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2010
U.S. locations: 4
States / cities: Daytona Beach, Florida • Evansville, Indiana • Portland, Oregon + 1 more

Conditions: Marijuana Dependence
Interventions: Nicotine, Cannabis, PAX Loose Leaf Vaporizer; Drug · Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use Disorder
Interventions: Cigarette flavor restricted and e-cigarette flavor restricted, Cigarette flavor restricted and e-cigarette flavor unrestricted, Cigarette flavor unrestricted and e-cigarette flavor restricted, Cigarette flavor unrestricted and e-cigarette flavor unrestricted; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 302 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Substance Withdrawal Syndrome
Interventions: Abstinence from e-cigarettes; Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 147 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 2
States / cities: Baltimore, Maryland • Burlington, Vermont

Conditions: Electronic Nicotine Delivery System Flavors
Interventions: Tobacco product administration and assessment; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 21 Years and older
Enrollment: 71 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Smoking, Tobacco Use
Interventions: Low Power, High Power, Low Concentration, High Concentration; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 93 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Charleston, South Carolina

Search by objective public record fields.

University of Michigan COPD Identification Through Lung Cancer Screening Cohort Study - MAP2

CSD201203: A Study to Determine Subject Puffing Patterns of a Non-cylindrical, Closed, Electronic Nicotine Delivery System at Three Nicotine Concentrations in an Ambulatory Setting

Investigation of the Impact of Smoking Status on Allergen-induced Nasal Airway Inflammation Using a Cat Hair (Felis Domesticus) Extract Nasal Allergen Challenge Model

Reduced Nicotine Content Cigarettes in Smokers of Lower Socioeconomic Status

Tailored Smoking Cessation Intervention in Promoting Sexual and Gender Minority Smokers to Quit Smoking

Assessing the Effect of Flavor on ENDS Users' Experiences and Exposures

Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers

Treating Smokers With Mental Illness

Trial for Harm Reduction With Incentives & Vaping E-cigarettes

Examination of Low Wattage and High Wattage E-Cigarettes

A Comparison of Exhaled Carbon Monoxide Measurements Using the iCOquit Smokerlyzer and Vitalograph Breath CO Monitor vs Carboxyhemoglobin From Venous Samples While Validating a Mobile Research Application

Assessing the Effect of Nicotine Reduction on ENDS User's Addiction and Exposures

Reduced Exposure Study Using THS 2.2 Menthol With 5 Days in a Confinement Setting Followed by 86 Days in an Ambulatory Setting

Effects of e-Cigarettes on Perceptions and Behavior - Substudy 1

Comparative Effectiveness of Post-Discharge Strategies for Hospitalized Smokers

Smoking Interventions for Hospital Patients

Impact of Cigarette and E-cigarette Flavors on Adult Smoking Behavior

IQOS (Non-Cigarette Tobacco Product) Pilot Study

Controlled Study of the Ability of a Smokefree Tobacco Product to Increase the Quit Rate Among Cigarette Smokers

Vaping THC From Electronic Cigarettes

Cigarette and E-cigarette Flavors Manipulations in the Experimental Tobacco Marketplace

Does Abstinence From E-cigarettes Produce Withdrawal Symptoms?

Potential Effects of Electronic Nicotine Delivery System Flavor Regulations on African American Menthol Smokers

Impact of E-cigarette Characteristics on Reinforcement and Tobacco Use Patterns