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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:21 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 169–192 of 798 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking Cigarette Clear all

Conditions: Nicotine Dependence
Interventions: Nicotine, behavioral counseling for smoking cessation; Drug · Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2021
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Bupropion Hydrochloride Controlled-release, Nicotine Replacement, Questionnaire Administration, Tobacco Cessation Counseling, Varenicline; Drug · Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 2,010 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2028
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Nicotine Dependence
Interventions: saline, Nicotine; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 213 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2016
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Tobacco Use Disorder
Interventions: Oral tobacco, Nicotine Gum; Other · Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 70 Years
Enrollment: 391 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2014
U.S. locations: 2
States / cities: Minneapolis, Minnesota • Eugene, Oregon

Conditions: Tobacco Dependence
Interventions: S-Adenosyl-L-Methionine, placebo; Drug · Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 2
States / cities: Rochester, Minnesota • La Crosse, Wisconsin

Conditions: Cigarette Smoking
Interventions: Mail-based Self-help plus Internet-based Smoking Treatment, Self-Help Manual plus Telephone counseling, Self-Help Manual, Self-Help Manual plus Internet-based Intervention plus Telephone Counseling; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 363 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Nicotine Dependence, Cigarettes
Interventions: Motivational Text Messages, Control; Behavioral
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years and older
Enrollment: 152 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Cigarette Smoking
Interventions: urine analyses feedback; Other
Lead sponsor: Masonic Cancer Center, University of Minnesota; Other
Eligibility: 18 Years to 75 Years
Enrollment: 109 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Cigarette Smoking, Tobacco Use
Interventions: Placebo, Gabapentin - 1800 mg/day, Gabapentin - 2700 mg/day; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Nicotine Addiction, Smoking Cessation
Interventions: Nicotine polacrilex, STAM 1100mAh CE4 eGo Clearomizer; Drug · Other
Lead sponsor: Creighton University; Other
Eligibility: 19 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Nicotine Dependence
Interventions: lorcaserin, nicotine patch, placebo lorcaserin; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 97 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Cannabis, Vaping, Emotion Regulation
Interventions: Virtual reality videogame intervention for vaping prevention; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 11 Years to 15 Years
Enrollment: 62 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Use Cessation, Tobacco Use, Electronic Cigarette Use
Interventions: UP2UTeacher; Behavioral
Lead sponsor: University of Virginia; Other
Eligibility: 14 Years to 15 Years
Enrollment: 520 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Smoking, Smoking Cessation, Craving, Addiction, Addiction Nicotine, Nicotine Dependence, Cigarette Smoking
Interventions: Real TBS to the vmPFC, Sham cTBS to the vmPFC; Device
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 75 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
Interventions: JUUL ENDS 5% Virginia Tobacco, JUUL 3% Virginia Tobacco ENDS, JUUL 5% Mint ENDS, JUUL 3% Mint ENDS, JUUL 5% Menthol ENDS, JUUL 3% Menthol ENDS, JUUL 5% Mango ENDS, JUUL 3% Mango ENDS, US Cigarette, Non-menthol - Marlboro Gold King Size, US Cigarette, Menthol - Newport King Size; Other
Lead sponsor: Juul Labs, Inc.; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 135 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 3
States / cities: Secaucus, New Jersey • Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Tobacco Use Disorder
Interventions: Psilocybin, Niacin; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years and older
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 3
States / cities: Birmingham, Alabama • Baltimore, Maryland • New York, New York

Conditions: Tobacco Abuse Cigarette
Interventions: Quitline facilitation intervention, Brief stop-smoking intervention; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Coronary Artery Disease, Myocardial Perfusion
Interventions: Cigarettes, E-cigarettes (nicotine free e-liquid), E-cigarettes (low nicotine e-liquid), E-cigarettes (high nicotine e-liquid); Other
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years to 49 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Smoking
Interventions: FT21039, FT21092, FT21018; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 114 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 2
States / cities: Overland Park, Kansas • Minneapolis, Minnesota

Conditions: Tobacco Products, Cigarettes, Electronic Cigarettes
Interventions: communication; Other
Lead sponsor: UNC Lineberger Comprehensive Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 99 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Smoking Cigarette, Smoking Behaviors, Vaping, Vaping Behaviors
Interventions: Not listed
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 21 Years to 65 Years
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Tobacco Use
Interventions: Ploom HTP Menthol HTS; MX3 (681), Ploom HTP Tobacco HTS; R8 (120), Smoking Abstinence (menthol), Smoking Abstinence (non-menthol); Other
Lead sponsor: Altria Client Services LLC; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 921 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 8
States / cities: Bentonville, Arkansas • Rogers, Arkansas • Overland Park, Kansas + 5 more

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: QuitBot Smoking Cessation Chatbot Program, QuitBot Smoking Cessation Text Messaging Program, Survey Administration, Interview, Carbon Monoxide Measurement; Device · Other · Procedure
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 772 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Smoking ( Cigarette)
Interventions: Charcoal filtered cigarettes with marketing, Charcoal filtered cigarette without marketing, Non-charcoal filtered cigarettes; Behavioral
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 21 Years and older
Enrollment: 252 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Search by objective public record fields.

Very Low-Nicotine Cigarettes in Smokers With SUD

Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial

Sensitivity to Intravenous Nicotine: Genetic Moderators

Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine

S-Adenosyl-L-Methionine (SAMe) for Smoking Abstinence

Reaching and Treating Lesbian, Gay, Bisexual, and Transgender (LGBT) Cigarette Smokers

Penn State TXT2Quit Study

Biomarker Feedback for Smoking Cessation

Gabapentin for Smoking Cessation

e-Cigarettes Versus NRT Gum for Smoking Cessation

Combination Nicotine Patch / Lorcaserin for Smoking Cessation

A Virtual Reality Game to Prevent E-cigarette and Cannabis Vaping

Development of UP2UTeacher for High School Youth

QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt

Evaluating Selected Constituents in the Exhaled Breath Samples

5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder

Helping Hospitalized Patients Quit Smoking

E-Cigarette Aerosol, Conventional Cigarette Smoke, and Myocardial Perfusion

CSD170501: Study to Assess Biomarkers of Tobacco Exposure in Smokers During In-Clinic Confinement Switch to an Electronic Cigarette

Pilot Study of Communication for Dual Users of Cigarettes and E-cigarettes

Vape Use Among Younger & Older Smokers

Changes in Biomarker of Exposure in Adults Who Smoke Cigarettes Switching From Cigarettes to Heated Tobacco Products

A Smartphone Application (QuitBot) for the Improvement of Smoking Cessation Among American Indians and Alaska Natives, NAITIVE Trial

Cigarette Filter Study