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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Smoking Dependence Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Exercise or Relaxation for Smoking Cessation

NCT00921388
View directory record Official record
Conditions
Nicotine Dependence, Smoking Cessation
Interventions
Varenicline and smoking cessation counseling, Exercise or relaxation treatment
Other · Behavioral
Lead sponsor
UConn Health
Other
Eligibility
45 Years and older · Female only
Enrollment
301 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2017
U.S. locations
2
States / cities
Farmington, Connecticut • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 30, 2017 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Phase 3 Interventional Results available

Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation

NCT01406223
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline, Bupropion, Nicotine patches, Placebo varenicline, Placebo bupropion, Placebo patch
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years
Enrollment
282 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
Durham, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 13, 2017 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

THC Crossover Study

NCT04429568
View directory record Official record
Conditions
THC, Cannabis, Cannabis Smoking, Cannabis Use, Unspecified, Cigarette Smoking, Tobacco Use, Nicotine Dependence, Nicotine Withdrawal, Cardiovascular Risk Factor
Interventions
Smoked Cannabis, Vaped Cannabis, Tobacco Cigarette
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 30, 2024 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study to Evaluate the Safety and Efficacy of Dietary Supplement Anatabloc in Reducing Daily Smokers' Urge to Smoke

NCT01428310
View directory record Official record
Conditions
Tobacco Use Disorder, Tobacco Dependence, Smoking
Interventions
Anatabloc(TM), CigRx(R)
Dietary Supplement
Lead sponsor
Rock Creek Pharmaceuticals, Inc.
Industry
Eligibility
23 Years to 72 Years
Enrollment
109 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Martinsburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 29, 2015 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults

NCT05897242
View directory record Official record
Conditions
Nicotine Dependence, Nicotine Addiction, Nicotine Use Disorder, Nicotine Vaping, Vaping
Interventions
Smartphone app, Text Message, Survey Administration
Behavioral · Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years to 30 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 23, 2025 · Synced Jul 22, 2026, 11:48 PM EDT
Recruiting Phase 1Phase 2 Interventional

Overcoming Nicotine Dependence to Enable Quitting

NCT05513872
View directory record Official record
Conditions
Tobacco Use, Smoking Cessation, Smoking Behaviors, Nicotine Dependence, Nicotine Withdrawal
Interventions
Nicotine Replacement Therapy (NRT) Sampling, Practice Quitting (PQ) Counseling, Motivational Interviewing (MI) Counseling
Drug · Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
780 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 16, 2025 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Phase 2 Interventional Results available

Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Female Smokers

NCT01926626
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine Patch, Moclobemide
Drug
Lead sponsor
Jed E. Rose
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
3
States / cities
Charlotte, North Carolina • Durham, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 22, 2017 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Emergency Department Telephone Quitline

NCT00394420
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Telephone Quitline
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2006
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 19, 2010 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Measuring Smoking Behaviors While Using Varenicline

NCT00948155
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 15, 2014 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Phase 3 Interventional Results available

Extended Varenicline Treatment for Smoking Among Cancer Patients

NCT01756885
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline, Placebo, Smoking Cessation Counseling
Drug · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
207 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
2
States / cities
Chicago, Illinois • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 29, 2019 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Phase 2 Interventional Results available

Effect of Ramelteon on Smoking Abstinence

NCT02560324
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Ramelteon, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 3, 2019 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reactions to E-cigs and Alcohol

NCT03449017
View directory record Official record
Conditions
Alcohol Abuse, Nicotine Dependence Tobacco Product
Interventions
E-cig use
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
21 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 28, 2018 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder

NCT05796791
View directory record Official record
Conditions
Tobacco Use, Smoking Cessation, Nicotine Dependence
Interventions
Ketamine Hydrochloride, Motivational enhancement therapy
Drug · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Jul 22, 2026, 11:48 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Adolescent Smokers

NCT01148355
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
13 Years to 17 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reduced Nicotine Cigarettes in Smokers With Mood and Anxiety Disorders

NCT01928758
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Reduced Nicotine Content Cigarettes, Usual Nicotine Content Cigarettes
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
245 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
2
States / cities
Boston, Massachusetts • Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 27, 2019 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Vigorous Exercise for Depressed Smokers

NCT01860924
View directory record Official record
Conditions
Nicotine Dependence, Depression
Interventions
exercise, health education
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 13, 2016 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Not applicable Interventional

VIDeOS for Smoking Cessation

NCT06307496
View directory record Official record
Conditions
Cancer, Smoking Cessation
Interventions
Smoking cessation intervention, Informational intervention
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Personalized Feedback for Smokers With Elevated Anxiety Sensitivity

NCT03382093
View directory record Official record
Conditions
Anxiety Disorders, Anxiety, Tobacco Dependence, Smoking, Cigarette, Smoking, Tobacco
Interventions
Personalized Feedback Intervention, Smoking Information Control
Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 18, 2019 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Phase 2 Interventional Results available

Varenicline Treatment of Alcohol Dependence in Smokers

NCT01553136
View directory record Official record
Conditions
Alcoholism, Alcohol Abuse, Smoking, Alcohol Drinking
Interventions
Varenicline
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 70 Years
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
2
States / cities
New Haven, Connecticut • New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 5, 2020 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Phase 2 Interventional Results available

Treatment With Mecamylamine in Smoking and Non-smoking Alcohol Dependent Patients

NCT00342563
View directory record Official record
Conditions
Alcoholism
Interventions
mecamylamine, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2015
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 3, 2019 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Social Media Intervention to Stop Nicotine and Cannabis Vaping Among Adolescents

NCT04707911
View directory record Official record
Conditions
Vaping
Interventions
Social Media Intervention
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
13 Years to 21 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 20, 2024 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cigarette Smoking in Smokers With and Without Schizophrenia

NCT04001114
View directory record Official record
Conditions
Tobacco Dependence, Schizophrenia
Interventions
Sampling Research Cigarettes
Combination Product
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 60 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 25, 2024 · Synced Jul 22, 2026, 11:48 PM EDT
Completed Not applicable Interventional

Counseling to Reduce Children's SHS Exposure: A Trial With Maternal Smokers

NCT02117947
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Behavioral Counseling, Self-help control
Behavioral
Lead sponsor
Temple University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 14, 2017 · Synced Jul 22, 2026, 11:48 PM EDT
Terminated No phase listed Observational

Tobacco Dependence in Breast Cancer Patients Trial of Varenicline (Chantix)

NCT01532232
View directory record Official record
Conditions
Breast Cancer, Tobacco Dependence
Interventions
placebo, varenicline
Drug
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 22, 2015 · Synced Jul 22, 2026, 11:48 PM EDT