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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Smoking E-cigarette Clear all
Completed Phase 4 Interventional

Methadone-Maintained Smokers Switching to E-Cigarettes

NCT05206435
View directory record Official record
Conditions
Nicotine Dependence, Electronic Cigarette Use
Interventions
Electronic Cigarette, Nicotine Lozenge
Drug
Lead sponsor
Butler Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
183 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Phase 2 Interventional Results available

A Study of Cytisinicline for Vaping Cessation in Adult Smokers

NCT05431387
View directory record Official record
Conditions
Vaping, E-Cig Use
Interventions
cytisinicline, Placebo, Behavioral support
Drug · Behavioral
Lead sponsor
Achieve Life Sciences
Industry
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
5
States / cities
Lexington, Kentucky • Boston, Massachusetts • Rochester, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional

Short Term Effects of Electronic Cigarettes in Tobacco Dependent Adults

NCT02498145
View directory record Official record
Conditions
Smoking, Nicotine Dependence
Interventions
Nicotine e-cigarette, Non-nicotine e-cigarette
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

E-cigarette Nicotine Study

NCT04709471
View directory record Official record
Conditions
Nicotine Dependence, Electronic Cigarette Use, Cigarette Smoking
Interventions
Nicotine, Juul e-cigarette, Reduction
Drug · Device · Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
21 Years and older
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Aug 25, 2022 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sex Differences in E-cig Perception: Study 1

NCT05432830
View directory record Official record
Conditions
Nicotine Addiction, E-Cig Use, Cigarette Smoking, Sex Differences
Interventions
E-liquid Flavor 1, E-liquid Flavor 2, E-liquid Flavor 3
Other
Lead sponsor
Yale University
Other
Eligibility
21 Years to 44 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Jun 25, 2026, 11:08 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

E-Cigarettes: Dynamic Patterns of Use and Health Effects

NCT02527980
View directory record Official record
Conditions
Smoking, Nicotine Dependence
Interventions
No intervention: observation only
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
422 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
2
States / cities
Madison, Wisconsin • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 9, 2019 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Combination of E-cigarettes and Varenicline for Tobacco Harm Reduction

NCT04210180
View directory record Official record
Conditions
Smoking Cessation, Harm Reduction
Interventions
Varenicline, e-cigarette
Drug · Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 23, 2022 · Synced Jun 25, 2026, 11:08 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Menthol on ENDS Users' Addiction and Exposure

NCT05338801
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Menthol-flavored e-cigarette, Tobacco-flavored e-cigarette
Other
Lead sponsor
Florida International University
Other
Eligibility
21 Years to 35 Years
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Examination of Low Wattage and High Wattage E-Cigarettes

NCT03113136
View directory record Official record
Conditions
Smoking, Cigarette, Smoking, Tobacco, Nicotine Dependence, Exposure to Toxic Agent
Interventions
Low wattage E cigarette device, High wattage E cigarette device, Usual brand cigarette
Behavioral
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years to 99 Years
Enrollment
372 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Acute Effect of Vaping on Food Intake

NCT04219189
View directory record Official record
Conditions
Energy Intake, Food Intake, E-Cig Use, Appetite
Interventions
Vaping condition, Control condition
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 4, 2023 · Synced Jun 25, 2026, 11:08 PM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

Switching to E-cigarettes in Smokers Not Interested in Quitting

NCT05703672
View directory record Official record
Conditions
Smoking Reduction
Interventions
Varenicline Tartrate, Placebo, Electronic cigarette
Drug · Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
2
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 28, 2025 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional Results available

Assessing E-Cigarettes for Tobacco Harm Reduction in the Context of Lung Cancer Screening

NCT06472869
View directory record Official record
Conditions
Electronic Cigarette Use, Smoking, Cigarette, Nicotine Dependence
Interventions
NJOY ACE e-cigarette
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Jun 25, 2026, 11:08 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation

NCT03721822
View directory record Official record
Conditions
Smoking, Cigarette, Smoking E-cigarette, Healthy Volunteer
Interventions
[18F]NOS
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 45 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Electronic Cigarette Use in Young Adult Men and Women

NCT03089541
View directory record Official record
Conditions
Cigarette Smoking, Tobacco Use
Interventions
Survey Arm
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 29 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Short-Term Cardiovascular Effects of E-Cigarettes: Influence of Device Power

NCT03839745
View directory record Official record
Conditions
Cardiovascular Risk Factor, Nicotine Dependence
Interventions
Electronic Cigarette
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 30, 2024 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessing the Effect of Flavor on ENDS Users' Experiences and Exposures

NCT04192032
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Preferred Juul pod flavor (5% nicotine), Classic Tobacco Juul pod flavor (5% nicotine), Preferred flavor with HWL, Preferred flavor, 3% nicotine, Preferred flavor, 0% nicotine
Other
Lead sponsor
Florida International University
Other
Eligibility
18 Years to 24 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jan 25, 2021 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Characterize Puff Topography With Use of JUUL 5% Electronic Nicotine Delivery Systems (ENDS) in Adult Smokers

NCT03596034
View directory record Official record
Conditions
Tobacco Use, Nicotine Dependence, Other Tobacco Product, Tobacco Smoking
Interventions
JUUL 5%, Virginia Tobacco, ENDS product
Other
Lead sponsor
Juul Labs, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 13, 2021 · Synced Jun 25, 2026, 11:08 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Effects of E-Cigarette Power and Nicotine Content in Dual Users and Vapers

NCT03830892
View directory record Official record
Conditions
Electronic Cigarettes
Interventions
E-cigarette Lab Session 15 watts, 10 mg nicotine, E-cigarette Lab Session 15 watts, 30 mg nicotine, E-cigarette Lab Session 30 watts, 10 mg nicotine, E-cigarette Lab Session 30 watts, 30 mg nicotine, Own Brand Session - E-cigarette, Own Brand Session - E-cigarette/Cigarette
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years to 55 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 3, 2021 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Appeal and Impact of E-Cigarettes Among Chronic Smokers With Smoking-Related Cancers

NCT02648178
View directory record Official record
Conditions
Nicotine Dependence, Other Tobacco Product, Bladder Cancer, Lung Cancer, Cancer of Head and Neck
Interventions
HALO
Device
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Sep 18, 2019 · Synced Jun 25, 2026, 11:08 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

E-Cigarette and Cigarette Nicotine Delivery and Abuse Liability in Cigarette Smokers and Dual Users

NCT03943706
View directory record Official record
Conditions
Tobacco Use
Interventions
Not listed
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 50 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 18, 2020 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of e-Cigarettes on Nicotine Withdrawal

NCT03098004
View directory record Official record
Conditions
Electronic Cigarettes
Interventions
e-Cigarette
Other
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 10, 2023 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A High School Program for Preventing Prescription Drug Misuse

NCT03219190
View directory record Official record
Conditions
Prescription Drug Abuse, Substance Abuse, Substance Use (Drugs, Alcohol)
Interventions
LST High School Hybrid
Behavioral
Lead sponsor
National Health Promotion Associates, Inc.
Industry
Eligibility
14 Years to 18 Years
Enrollment
1,804 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Jun 25, 2026, 11:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors

NCT03185546
View directory record Official record
Conditions
Smoking
Interventions
NNC Spectrum Cigarette, VLNC Spectrum Cigarette, Moderate nicotine level e-liquid, Low nicotine level e-liquid, Tobacco Flavors, Tobacco and non-tobacco e-liquid flavors
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
2
States / cities
Winston-Salem, North Carolina • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 13, 2021 · Synced Jun 25, 2026, 11:08 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

A Virtual Reality Vaping Prevention Intervention for Adolescents

NCT07362069
View directory record Official record
Conditions
Vaping
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
12 Years to 15 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
2
States / cities
New Haven, Connecticut • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Jun 25, 2026, 11:08 PM EDT