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Showing 1–24 of 107 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Social Isolation Clear all
Completed No phase listed Observational Accepts healthy volunteers

Discrimination and the Brain-Gut-Microbiome (BGM) Axis

NCT05120908
View directory record Official record
Conditions
Discrimination, Racial, Social Isolation, Stress
Interventions
Not listed
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
266 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 9, 2025 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Not applicable Interventional

Management of Depression and Social Isolation in Older Adults With Dementia With Home-based Telehealth Delivered Behavioral Activation + Caregiver Facilitation.

NCT04915040
View directory record Official record
Conditions
Depression
Interventions
Behavioral Activation for Depression
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
65 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 29, 2023 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Oxytocin and Social Behavior Over the Lifespan

NCT00914953
View directory record Official record
Conditions
Social Activity
Interventions
oxytocin (Pitocin)
Drug
Lead sponsor
Claremont Graduate University
Other
Eligibility
50 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Mar 1, 2012 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Internet-based Conversational Engagement Clinical Trial

NCT02871921
View directory record Official record
Conditions
Aging, Mild Cognitive Impairment
Interventions
Conversational Engagement
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
75 Years and older
Enrollment
186 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
Boston, Massachusetts • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 1, 2024 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Not applicable Interventional

Bridging Community Gaps Photovoice

NCT03291717
View directory record Official record
Conditions
Mental Illness, Social Isolation
Interventions
Bridging Community Gaps Photovoice (BCGP)
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
197 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
4
States / cities
Denver, Colorado • Bridgeport, Connecticut • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 15, 2020 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Personalized Reminder Information and Social Management System

NCT01497613
View directory record Official record
Conditions
Social Isolation, Social Support (Formal and Informal), Well-being/Quality of Life
Interventions
PRISM C: Computer Condition, PRISM B: Notebook Condition
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
65 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jan 22, 2019 · Synced Jul 21, 2026, 11:30 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Determining How Indoor Lighting Affects the Brain Health of Older Adults

NCT05978934
View directory record Official record
Conditions
Sleep, Physical Activity, Cognitive Function, Social Isolation
Interventions
Static Lighting Condition (L1), Dynamic Lighting Condition (L2), Dynamic Lighting Condition (L3)
Behavioral
Lead sponsor
Well Living Lab, Inc.
Industry
Eligibility
60 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 6, 2023 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Proactive Social Robot for Older Adults in Reducing Loneliness and Social Isolation

NCT03972787
View directory record Official record
Conditions
Loneliness, Mood, Quality of Life
Interventions
Proactive social robot
Device
Lead sponsor
Baycrest
Other
Eligibility
70 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 4, 2021 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Not applicable Interventional

Utilizing Novel Information Technology to Promote Exercise and Well-Being in Adolescents and Young Adults With Cancer

NCT03778658
View directory record Official record
Conditions
Adolescent, Young Adult, Cancer, Physical Activity, Psychological Distress, Social Isolation
Interventions
Physical Activity Intervention
Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
15 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 7, 2024 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Stay Healthy In Nature Everyday: Family Nature Outings in a Low Income Population

NCT02623855
View directory record Official record
Conditions
Stress, Psychological, Social Isolation, Physical Activity
Interventions
Family outings, Park prescription, Pedometry, Case Management
Behavioral · Device
Lead sponsor
UCSF Benioff Children's Hospital Oakland
Other
Eligibility
4 Years and older
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Nov 29, 2020 · Synced Jul 21, 2026, 11:30 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Social Disconnection Study

NCT06705348
View directory record Official record
Conditions
Social Disconnection
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
55 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Protective Effect of Friendship on Peer Rejection in Overweight and Normal Weight Youth

NCT01324661
View directory record Official record
Conditions
Social Exclusion, Control
Interventions
Ostracism
Behavioral
Lead sponsor
University at Buffalo
Other
Eligibility
12 Years to 14 Years
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Sep 29, 2011 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Personalized Health Behavior System

NCT03538158
View directory record Official record
Conditions
Social Isolation, Aging, Physical Activity
Interventions
Intervention Condition, Control Condition
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
60 Years and older
Enrollment
181 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
Miami, Florida • New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 11, 2022 · Synced Jul 21, 2026, 11:30 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Sisters for Heart Health: A Community Health Worker Initiative for Improving Heart Health in Farmworker Women

NCT07111026
View directory record Official record
Conditions
Occupational Stress, Gender Related Stress, Social Isolation, Hypertension, Pre Diabetes, Diabetes, Obesity
Interventions
Sisters for Heart Health, Basic intervention
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
269 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Ellenton, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 21, 2026, 11:30 AM EDT
Recruiting Not applicable Interventional

Increasing Veterans' Social Engagement and Connectedness

NCT06467214
View directory record Official record
Conditions
Social Isolation
Interventions
CONNECTED, VET BEFRIENDING
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
264 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Jul 21, 2026, 11:30 AM EDT
Completed No phase listed Observational

Emotional, Social, Cognitive and Behavioral Sequalae of the COVID-19 Pandemic

NCT04823988
View directory record Official record
Conditions
Healthy Volunteer
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 99 Years
Enrollment
2,086 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mobilizing Community Networks to Optimize Child Well-being

NCT02622399
View directory record Official record
Conditions
Social Isolation
Interventions
Project NOW
Behavioral
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 64 Years
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 27, 2017 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

PRISM 2.0 in Diverse Living Contexts

NCT03116399
View directory record Official record
Conditions
Social Isolation in Older Adults
Interventions
PRISM 2.0 Condition, Tablet Condition
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
65 Years and older
Enrollment
248 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
4
States / cities
Miami, Florida • Tallahassee, Florida • Atlanta, Georgia + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 25, 2022 · Synced Jul 21, 2026, 11:30 AM EDT
Recruiting Not applicable Interventional

A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults

NCT06919094
View directory record Official record
Conditions
Apathy, Loneliness, Reminiscence Therapy
Interventions
Life Story Club
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
60 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Not applicable Interventional

Caring Connections: A Program to Alleviate Social Isolation and Loneliness in Individuals Living With Spinal Cord Injury

NCT05295108
View directory record Official record
Conditions
Spinal Cord Injuries and Disorders (SCI/D)
Interventions
Caring Connections, Attention control
Other
Lead sponsor
Chicago Association for Research and Education in Science
Other
Eligibility
18 Years to 90 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Not applicable Interventional Results available

Connect for Caregivers

NCT04919070
View directory record Official record
Conditions
Social Isolation, Loneliness
Interventions
Connect for Caregivers
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
50 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
2
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 28, 2022 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Not applicable Interventional Results available

Mindfulness to Reduce Loneliness in Older Caregivers

NCT04560088
View directory record Official record
Conditions
Social Isolation, Loneliness
Interventions
Mindfulness, Breathing
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
50 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 1, 2025 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Not applicable Interventional Results available

Engage Psychotherapy to Promote Connectedness in Caregivers

NCT04176601
View directory record Official record
Conditions
Loneliness, Social Isolation, Caregiver Burnout
Interventions
Engage coaching
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
50 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 24, 2025 · Synced Jul 21, 2026, 11:30 AM EDT
Completed Not applicable Interventional

Social Prescribing and Relationship Cognitive Strategies (SPARCS)

NCT06656975
View directory record Official record
Conditions
Social Isolation, Suicidal Ideation
Interventions
Brief Cognitive Therapy, Social Prescribing, Enhanced Usual Care
Behavioral · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Brighton, Michigan • Canton, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Jul 21, 2026, 11:30 AM EDT