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Showing 1–20 of 20 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Social Isolation in Older Adults Clear all
Completed Not applicable Interventional

Management of Depression and Social Isolation in Older Adults With Dementia With Home-based Telehealth Delivered Behavioral Activation + Caregiver Facilitation.

NCT04915040
View directory record Official record
Conditions
Depression
Interventions
Behavioral Activation for Depression
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
65 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 29, 2023 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Proactive Social Robot for Older Adults in Reducing Loneliness and Social Isolation

NCT03972787
View directory record Official record
Conditions
Loneliness, Mood, Quality of Life
Interventions
Proactive social robot
Device
Lead sponsor
Baycrest
Other
Eligibility
70 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 4, 2021 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Personalized Health Behavior System

NCT03538158
View directory record Official record
Conditions
Social Isolation, Aging, Physical Activity
Interventions
Intervention Condition, Control Condition
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
60 Years and older
Enrollment
181 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
Miami, Florida • New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 11, 2022 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

PRISM 2.0 in Diverse Living Contexts

NCT03116399
View directory record Official record
Conditions
Social Isolation in Older Adults
Interventions
PRISM 2.0 Condition, Tablet Condition
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
65 Years and older
Enrollment
248 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
4
States / cities
Miami, Florida • Tallahassee, Florida • Atlanta, Georgia + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 25, 2022 · Synced Jul 21, 2026, 7:29 PM EDT
Recruiting Not applicable Interventional

A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults

NCT06919094
View directory record Official record
Conditions
Apathy, Loneliness, Reminiscence Therapy
Interventions
Life Story Club
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
60 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Intelligent Personal Assistant for Managing Depression in Homebound Older Adults

NCT04900272
View directory record Official record
Conditions
Aging, Physical Dependence
Interventions
VIPA and companion booklet
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
65 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 19, 2024 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Video Chat During Meals to Improve Nutritional Intake in Older Adults

NCT04862312
View directory record Official record
Conditions
Malnutrition, Loneliness
Interventions
VideoDine
Behavioral
Lead sponsor
Cornell University
Other
Eligibility
60 Years to 95 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Ithaca, New York
Source: ClinicalTrials.gov public record
Updated Sep 25, 2022 · Synced Jul 21, 2026, 7:29 PM EDT
Completed No phase listed Observational

Discharge Functional Status and Rehospitalization in the Elderly

NCT02041585
View directory record Official record
Conditions
Social Isolation, Depression, Anxiety, Debility
Interventions
Not listed
Lead sponsor
Northwestern University
Other
Eligibility
65 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 5, 2023 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Impact of a Telephone Reminiscence Program

NCT05977608
View directory record Official record
Conditions
Mental Health, Loneliness, Social Isolation
Interventions
Telephone Reminiscence Intervention
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
60 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Jul 21, 2026, 7:29 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Virtual Senior Center

NCT06946186
View directory record Official record
Conditions
Social Isolation in Older Adults, Quality of Life (QOL), Activities of Daily Living
Interventions
Virtual Senior Center - GrandPad, Virtual Senior Center - No GrandPad
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
65 Years and older
Enrollment
650 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Impact of Community Exercise on Social Connectedness and Falls in Older Adults: Leveraging Exercise to Age in Place

NCT03624049
View directory record Official record
Conditions
Social Isolation, Fall
Interventions
Exercise, Health Class
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
50 Years and older
Enrollment
671 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
9
States / cities
Beverly Hills, California • Los Angeles, California • West Hollywood, California
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Not applicable Interventional

Impact of Covid-19 on Frequent Social Interaction Through Communication Technologies in the Cognitive Status of Socially-isolated Older Adults

NCT04480112
View directory record Official record
Conditions
Memory Disorders, Alzheimer Disease, Mild Cognitive Impairment
Interventions
Technology based social interactions, No research related technology based social interactions
Behavioral · Other
Lead sponsor
Boston University
Other
Eligibility
Not listed
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 29, 2021 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Combatting Social Isolation in Older Adults

NCT05426837
View directory record Official record
Conditions
Loneliness, Social Isolation
Interventions
Combatting Social Isolation, Health Education Training
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
60 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Jul 21, 2026, 7:29 PM EDT
Not yet recruiting Not applicable Interventional

AI-CONECT: A Conversational AI for Early Dementia Prevention in Socially-Isolated Older Adults

NCT07701668
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Social Isolation
Interventions
AI-based conversational intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
75 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

In-home Yoga for Seniors

NCT05287529
View directory record Official record
Conditions
Aging Well
Interventions
Yoga Via Telehealth - Immediately, Yoga Via Telehealth - Waitlisted
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
60 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Jul 21, 2026, 7:29 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Effect of a Telephone Reminiscence Intervention on Mental Health

NCT07576855
View directory record Official record
Conditions
Mental Health
Interventions
Telephone Reminiscence Program
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
60 Years and older
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jul 21, 2026, 7:29 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Increasing Physical Activity Through Social Support and Stress Resilience

NCT06896825
View directory record Official record
Conditions
Healthy, Subjective Cognitive Decline (SCD), Sedentary Behavior, Social Isolation in Older Adults
Interventions
Self-monitoring
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
60 Years and older
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Arts Engagement on Physical Performance, Cognition, Social Isolation, and Self-Perception in Older Adults

NCT04281654
View directory record Official record
Conditions
Social Isolation, Mental Status Change, Cognitive Impairment, Physical Activity, Quality of Life, Self-Perception
Interventions
Active Social Conversation
Other
Lead sponsor
George Mason University
Other
Eligibility
65 Years to 100 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Manassas, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 3, 2022 · Synced Jul 21, 2026, 7:29 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

CAPABLE Care + Connect

NCT07123298
View directory record Official record
Conditions
Social Isolation in Older Adults, Social Isolation or Loneliness, Social Isolation, Quality of Life, Disability Physical, Homebound Persons
Interventions
CAPABLE Care + Connect - Open Label Pilot, CAPABLE Care + Connect - Pilot
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years and older
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jul 21, 2026, 7:29 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

LEAPTogether: An Intergenerational Intervention to Address Loneliness and Social Isolation

NCT05831475
View directory record Official record
Conditions
Social Isolation, Loneliness, Intergenerational Relations
Interventions
Intergenerational Virtual Paired Exercise, Peer Virtual Paired Exercise
Behavioral
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Beverly Hills, California
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Jul 21, 2026, 7:29 PM EDT