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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Speech Impairment Clear all
Completed No phase listed Observational

Stroke-like Migraine Attacks After Radiation Treatment (SMART) Syndrome Language Intervention

NCT03662295
View directory record Official record
Conditions
Migraine Disorders, Aphasia
Interventions
Language treatment
Behavioral
Lead sponsor
Quality Living, Inc.
Other
Eligibility
19 Years to 65 Years
Enrollment
1 participant
Timeline
2018 – 2019
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Mar 9, 2021 · Synced Jun 10, 2026, 2:08 PM EDT
Not yet recruiting Not applicable Interventional

Combined Aphasia and Robot-Assisted Arm Treatment for Chronic Stroke Survivors

NCT07000019
View directory record Official record
Conditions
Stroke, Aphasia Following Cerebral Infarction, Hemiparesis After Stroke
Interventions
CARAT: combined aphasia and robot-assisted arm therapy, Robot-assisted arm therapy
Behavioral
Lead sponsor
New York Medical College
Other
Eligibility
18 Years to 90 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Valhalla, New York
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Jun 10, 2026, 2:08 PM EDT
Completed Not applicable Interventional

Analysis of Brain Activity to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia

NCT03550092
View directory record Official record
Conditions
Aphasia
Interventions
Abstract Semantic Association Network Training (AbSANT)
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
Not listed
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 28, 2025 · Synced Jun 10, 2026, 2:08 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Developmental Framework For Linking Phonological And Morpho-syntactic Sequential Pattern Rules In DLD: Production

NCT04558541
View directory record Official record
Conditions
Developmental Language Disorder, Speech Sound Disorder, Specific Language Impairment
Interventions
Sensitivity to phonological rules, Sensitivity to semantic category cues.
Other
Lead sponsor
Father Flanagan's Boys' Home
Other
Eligibility
4 Years to 8 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
2
States / cities
Tucson, Arizona • Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Oct 26, 2025 · Synced Jun 10, 2026, 2:08 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Understanding Aided Speech Perception in Noise

NCT06377215
View directory record Official record
Conditions
Hearing Impairment, Sensorineural, Spatial Perception, Aging, Hearing Aids
Interventions
Open-source master hearing aid
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Jun 10, 2026, 2:08 PM EDT
Completed Not applicable Interventional Results available

Transcranial Direct Current Stimulation for Primary Progressive Aphasia

NCT02928848
View directory record Official record
Conditions
Primary Progressive Aphasia
Interventions
transcranial direct current stimulation
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
45 Years to 80 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 2, 2021 · Synced Jun 10, 2026, 2:08 PM EDT
Completed Not applicable Interventional

Aphasia Rehabilitation: Modulating Cues, Feedback & Practice

NCT01597037
View directory record Official record
Conditions
Aphasia, Stroke
Interventions
Script training
Behavioral
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 29, 2018 · Synced Jun 10, 2026, 2:08 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Brain-based Understanding of Individual Language Differences After Stroke

NCT04991519
View directory record Official record
Conditions
Aphasia, Stroke, Alexia
Interventions
Not listed
Lead sponsor
Georgetown University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2028
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Nov 11, 2024 · Synced Jun 10, 2026, 2:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Emotional Processes on Speech Motor Control in Early Childhood Stuttering.

NCT05003583
View directory record Official record
Conditions
Stuttering, Childhood
Interventions
Speaking after viewing pictures with negative and neutral valence
Behavioral
Lead sponsor
Syracuse University
Other
Eligibility
3 Years to 10 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Jun 10, 2026, 2:08 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Transcranial Alternating Current Stimulation (tACS) in Aphasia

NCT04375722
View directory record Official record
Conditions
Aphasia, Stroke
Interventions
tACS
Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2030
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 24, 2025 · Synced Jun 10, 2026, 2:08 PM EDT
Completed Not applicable Interventional

ECoLoGiC Speech Therapy for Everyday Communication in Aphasia

NCT06132464
View directory record Official record
Conditions
Aphasia
Interventions
Expanding Communication and Language Generated in Conversation Treatment
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Jun 10, 2026, 2:08 PM EDT
Recruiting Not applicable Interventional

Voiceitt for People With Impairments in Speech

NCT06874322
View directory record Official record
Conditions
Speech Impairment, Speech Disorder
Interventions
Voiceitt
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
13 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Jun 10, 2026, 2:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Intensive Group Behavioral Treatment for Children With Selective Mutism

NCT03612102
View directory record Official record
Conditions
Selective Mutism
Interventions
Intensive Group Behavioral Treatment (IGBT)
Behavioral
Lead sponsor
Florida International University
Other
Eligibility
5 Years to 9 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Jun 10, 2026, 2:08 PM EDT
Completed Phase 1 Interventional Results available

Assessment of Hyperphosphorylated Tau PET Binding in Primary Progressive Aphasia and Frontotemporal Dementia

NCT02736695
View directory record Official record
Conditions
Primary Progressive Aphasia, Behavioral Variant of Frontotemporal Dementia, Frontotemporal Dementia, Behavioral Variant
Interventions
F-18 AV 1451
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Jun 10, 2026, 2:08 PM EDT
Completed Phase 1 Interventional

Improve Speech Using an In-the-ear Device in Parkinson's Disease

NCT00488657
View directory record Official record
Conditions
Parkinson's Disease, Dysarthria
Interventions
SpeechEasy Model ITC
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
25 Years to 90 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 17, 2013 · Synced Jun 10, 2026, 2:08 PM EDT
Not yet recruiting Phase 2 Interventional

Effects of Psilocybin on Speech Fluency, Struggle, and Brain Activity in People Who Stutter

NCT07296328
View directory record Official record
Conditions
Stuttering
Interventions
Psilocybin, Speech therapy
Drug · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 50 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Jun 10, 2026, 2:08 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

UPenn Observational Research Repository on Neurodegenerative Disease

NCT04715399
View directory record Official record
Conditions
Frontotemporal Degeneration(FTD), Primary Progressive Aphasia(PPA), Familial Frontotemporal Lobar Degeneration (fFTLD), Amyotrophic Lateral Sclerosis(ALS), Lewy Body Disease(LBD), Progressive Supranuclear Palsy(PSP), Corticobasal Syndrome(CBS), Posterior Cortical Atrophy(PCA), Alzheimer's Disease(AD)
Interventions
No intervention
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2070
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Jun 10, 2026, 2:08 PM EDT
Completed Not applicable Interventional

Speech-derived Digital Biomarkers Study

NCT06994767
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Alzheimer Disease
Interventions
The Canary Application
Other
Lead sponsor
Hackensack Meridian Health
Other
Eligibility
50 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Hackensack, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Jun 10, 2026, 2:08 PM EDT
Not listed Not applicable Interventional

Narrative Comprehension by People With Acquired Brain Injury

NCT03309930
View directory record Official record
Conditions
Aphasia, Traumatic Brain Injury
Interventions
Comprehension Acquired Brain Injury
Behavioral
Lead sponsor
Miami University
Other
Eligibility
19 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Oxford, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 15, 2017 · Synced Jun 10, 2026, 2:08 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Auditory Masking Effects on Speech Fluency in Aphasia and Apraxia of Speech

NCT02094014
View directory record Official record
Conditions
Apraxia of Speech, Aphasia, Cerebrovascular Accident
Interventions
Normal Auditory Feedback, Masked Auditory Feedback, Altered Auditory Feedback
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 11, 2016 · Synced Jun 10, 2026, 2:08 PM EDT
Completed Not applicable Interventional

Enhancing Written Communication in Persons With Aphasia

NCT01790880
View directory record Official record
Conditions
Aphasia, Stroke
Interventions
ORLA, ORLA + Writing
Behavioral
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 17, 2020 · Synced Jun 10, 2026, 2:08 PM EDT
Not listed Phase 2Phase 3 Interventional

Efficacy and Tolerability of Ecopipam in Adults With Childhood Onset Fluency Disorder (Stuttering).

NCT02909088
View directory record Official record
Conditions
Stuttering, Adult, Childhood-onset Fluency Disorder, Speech Disorders, Language Disorders, Communication Disorder
Interventions
Ecopipam 50mg, Ecopipam 100mg
Drug
Lead sponsor
Gerald Maguire, MD
Other
Eligibility
18 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
2
States / cities
Riverside, California
Source: ClinicalTrials.gov public record
Updated Oct 25, 2016 · Synced Jun 10, 2026, 2:08 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Perception of Speech in Context by Listeners With Healthy and Impaired Hearing

NCT06465979
View directory record Official record
Conditions
Hearing, Hearing Loss
Interventions
Speech Manipulation
Behavioral
Lead sponsor
Marquette University
Other
Eligibility
18 Years to 65 Years
Enrollment
680 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
2
States / cities
Minneapolis, Minnesota • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Jun 10, 2026, 2:08 PM EDT
Completed Not applicable Interventional Results available

Stepped Care for Aphasia

NCT05851573
View directory record Official record
Conditions
Aphasia, Stroke
Interventions
Psychosocial intervention
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 81 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 23, 2025 · Synced Jun 10, 2026, 2:08 PM EDT