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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Spermatozoa Clear all
Completed No phase listed Observational

Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors

NCT00499798
View directory record Official record
Conditions
Brain and Central Nervous System Tumors, Chemotherapeutic Agent Toxicity, Infertility
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2014
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 29, 2017 · Synced Jul 23, 2026, 5:49 AM EDT
Enrolling by invitation Phase 2 Interventional

Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm

NCT07481370
View directory record Official record
Conditions
Oligospermia, Azoospermia, Nonobstructive, Infertility
Interventions
isotretinoin, Human chorionic gonadotrophin (hCG)
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 50 Years · Male only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Apr 19, 2026 · Synced Jul 23, 2026, 5:49 AM EDT
Completed Phase 2 Interventional Results available

To Evaluate Sperm Parameters in Men With Secondary Hypogonadism Previously Treated With Topical Testosterone

NCT00706719
View directory record Official record
Conditions
Secondary Hypogonadism
Interventions
25 mg Androxal, Testim 1%
Drug
Lead sponsor
Repros Therapeutics Inc.
Industry
Eligibility
21 Years to 60 Years · Male only
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
2
States / cities
New York, New York • Purchase, New York
Source: ClinicalTrials.gov public record
Updated Aug 18, 2015 · Synced Jul 23, 2026, 5:49 AM EDT
Completed No phase listed Observational

Short Term Genetic Effects of Chemotherapy on Male Germ Cells

NCT02975245
View directory record Official record
Conditions
Cancer
Interventions
Semen collection and analysis
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 50 Years · Male only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Jul 23, 2026, 5:49 AM EDT
Completed No phase listed Observational

Sperm Banking Among Adolescents Newly Diagnosed With Cancer: Development of a Profiling and Referral Tool

NCT01152268
View directory record Official record
Conditions
Cancer
Interventions
Not listed
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
13 Years to 21 Years · Male only
Enrollment
282 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
8
States / cities
Duarte, California • Los Angeles, California • Atlanta, Georgia + 5 more
Source: ClinicalTrials.gov public record
Updated Mar 9, 2015 · Synced Jul 23, 2026, 5:49 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Impact of Escitalopram on Sperm DNA Fragmentation

NCT03527043
View directory record Official record
Conditions
Sperm DNA Fragmentation, Infertility, Male
Interventions
Escitalopram, Placebo
Drug · Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Jul 23, 2026, 5:49 AM EDT
Terminated Not applicable Interventional Results available

Effectiveness of Celecoxib After Surgical Sperm Retrieval

NCT01323595
View directory record Official record
Conditions
Pain
Interventions
Celecoxib, Sugar Pill
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 1, 2018 · Synced Jul 23, 2026, 5:49 AM EDT
Completed No phase listed Observational

Correlating In Vitro Fertilization Outcomes After Euploid Blastocyst Transfer With Sperm DNA Fragmentation

NCT02268123
View directory record Official record
Conditions
Male Infertility
Interventions
Not listed
Lead sponsor
Reproductive Medicine Associates of New Jersey
Other
Eligibility
35 Years to 40 Years
Enrollment
323 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
2
States / cities
Basking Ridge, New Jersey • Allentown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 10, 2018 · Synced Jul 23, 2026, 5:49 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Ramipril for the Treatment of Oligospermia

NCT01856361
View directory record Official record
Conditions
Oligospermia, Teratospermia, Asthenozoospermia, Male Infertility
Interventions
Ramipril, Placebo
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 45 Years · Male only
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 1, 2017 · Synced Jul 23, 2026, 5:49 AM EDT
Completed Not applicable Interventional

Effectiveness of the Use of the PICSI Dish (Hyaluronan Microdot) in the Selection of Sperm for Intracytoplasmic Sperm Injection (ICSI)

NCT00741494
View directory record Official record
Conditions
Male Factor Infertility
Interventions
PICSI dish
Device
Lead sponsor
Biocoat
Industry
Eligibility
18 Years to 40 Years
Enrollment
801 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2008
U.S. locations
9
States / cities
Laguna Hills, California • San Ramon, California • Atlanta, Georgia + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 27, 2010 · Synced Jul 23, 2026, 5:49 AM EDT
Recruiting Not applicable Interventional

The EPIC Study: Exploring Paternal Age and the Influence on Blastocyst Culture

NCT06629766
View directory record Official record
Conditions
Infertility (IVF Patients), Oocyte Competence, Sperm DNA Fragmentation, Paternal Age, Sperm Selection
Interventions
Microfluidic sperm separation device, Density grade centrifugation
Device · Other
Lead sponsor
Reproductive Medicine Associates of New Jersey
Other
Eligibility
18 Years to 41 Years · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Basking Ridge, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Jul 23, 2026, 5:49 AM EDT
Terminated No phase listed Observational

Effect of Natural Antioxidant Supplement on Sperm DNA Fragmentation

NCT03646825
View directory record Official record
Conditions
Observe Effect of Antioxidant on Sperm DNA Fragmention
Interventions
Natural Antioxidant supplement
Dietary Supplement
Lead sponsor
Colorado Center for Reproductive Medicine
Other
Eligibility
18 Years to 55 Years · Male only
Enrollment
54 participants
Timeline
2018 – 2022
U.S. locations
1
States / cities
Lone Tree, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 22, 2023 · Synced Jul 23, 2026, 5:49 AM EDT
Completed No phase listed Observational

Human Sperm Binding to Transgenic Mouse Eggs

NCT00340587
View directory record Official record
Conditions
Fertilization
Interventions
Not listed
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Jul 23, 2026, 5:49 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Pharmacokinetic Study of Avanfil in Healthy Young Male Subjects

NCT00914511
View directory record Official record
Conditions
Avanfil ADME, Semen Exposure, Sperm Function
Interventions
avanafil 200mg
Drug
Lead sponsor
VIVUS LLC
Industry
Eligibility
18 Years and older · Male only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Tempe, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 6, 2011 · Synced Jul 23, 2026, 5:49 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Evaluating the Safety and Clinical Efficacy of the BAIBYS™ System in Intracytoplasmic Sperm Injection (ICSI)

NCT06990906
View directory record Official record
Conditions
Male Infertility, Azoospermia
Interventions
BAIBYS Sperm selection, Intra cytoplasmatic sperm injection, Conventional manual sperm selection
Device · Procedure
Lead sponsor
BAIBYS Fertility
Industry
Eligibility
21 Years to 42 Years
Enrollment
260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Stamford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jul 23, 2026, 5:49 AM EDT
Terminated Not applicable Interventional

Fresh Vs Frozen Surgical Sperm in IVF

NCT03361982
View directory record Official record
Conditions
Infertility
Interventions
Slow Freezing and Thawing
Other
Lead sponsor
Reproductive Medicine Associates of New Jersey
Other
Eligibility
Not listed
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Basking Ridge, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 27, 2022 · Synced Jul 23, 2026, 5:49 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Choline Dehydrogenase and Sperm Function: Effects of Betaine

NCT02122211
View directory record Official record
Conditions
Men Carrying 2 Minor Alleles for Choline Dehydrogenase rs12676, Male Infertility
Interventions
Betaine supplement
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 7, 2016 · Synced Jul 23, 2026, 5:49 AM EDT
Terminated Phase 3 Interventional Results available

Aromatase Inhibitors in the Treatment of Male Infertility

NCT00440180
View directory record Official record
Conditions
Obesity, Oligospermia
Interventions
Anastrozole, Placebo
Drug
Lead sponsor
University of Utah
Other
Eligibility
16 Years to 80 Years · Male only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 5, 2016 · Synced Jul 23, 2026, 5:49 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Automated Intracytoplasmic Sperm Injection (ICSIA)

NCT05633316
View directory record Official record
Conditions
Infertility, Female
Interventions
Investigational device named ICSIA, Manual ICSI
Device
Lead sponsor
Overture Life
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 5, 2023 · Synced Jul 23, 2026, 5:49 AM EDT
Completed Phase 3 Interventional

A Randomized, Double Blind, Placebo-Controlled, Multi-Center Phase III Study in Men With Acquired Hypogonadotropic Hypogonadism to Compare Changes in Testosterone and Sperm Concentration Following Treatment With 12.5 mg or 25 mg Androxal or AndroGel 1.62%

NCT01993225
View directory record Official record
Conditions
Secondary Hypogonadism
Interventions
Androxal 12.5 mg/25 mg, Placebo Capsules, AndroGel 1.62%, Placebo Gel
Drug
Lead sponsor
Repros Therapeutics Inc.
Industry
Eligibility
18 Years to 60 Years · Male only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
9
States / cities
Birmingham, Alabama • Mobile, Alabama • Evanston, Illinois + 6 more
Source: ClinicalTrials.gov public record
Updated Sep 30, 2014 · Synced Jul 23, 2026, 5:49 AM EDT
Completed Not applicable Interventional

Zona Pellucida Bound Sperm vs. Embryologist Selected Sperm for Intracytoplasmic Sperm Injection

NCT05859152
View directory record Official record
Conditions
Infertility
Interventions
Zona Pellucida-Bound Sperm Selection for ICSI, Routine Embryologist Selected Sperm
Other
Lead sponsor
IVI America
Other
Eligibility
18 Years to 41 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Jul 23, 2026, 5:49 AM EDT
Terminated No phase listed Observational

The Effect of Methotrexate on Sperm Quality in Men With Inflammatory Bowel Disease

NCT02461784
View directory record Official record
Conditions
Inflammatory Bowel Disease (IBD)
Interventions
Semen & Data Collection
Procedure
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 8, 2023 · Synced Jul 23, 2026, 5:49 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Effects of NLS-133, a Potential Non-Hormonal "On-Demand" Male Contraceptive

NCT07393334
View directory record Official record
Conditions
Male Contraception, Semen Volume, Sperm Motility
Interventions
NLS-133, Placebo, Active Comparator #1
Drug
Lead sponsor
Next Life Sciences
Industry
Eligibility
18 Years to 55 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Jul 23, 2026, 5:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

FemaSeed LOCAL Artificial Insemination Trial

NCT04968847
View directory record Official record
Conditions
Infertility, Male Factor
Interventions
FemaSeed Localized Directional Insemination
Device
Lead sponsor
Femasys Inc.
Industry
Eligibility
19 Years to 40 Years · Female only
Enrollment
314 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
18
States / cities
Mobile, Alabama • Newark, Delaware • Clearwater, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Nov 7, 2024 · Synced Jul 23, 2026, 5:49 AM EDT