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ClinicalTrials.gov public records Last synced Oct 3, 2026, 6:56 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 141 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Spine Degeneration Clear all
Completed No phase listed Observational

Outcome Analysis for Minimally Invasive Spine Surgery and Navigation

NCT01751841
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Not listed
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 29, 2024 · Synced Oct 3, 2026, 6:56 PM EDT
Not listed Phase 1Phase 2 Interventional

Safety Evaluation of ART352-L in Subjects Undergoing Posterolateral Spinal Fusion

NCT04378543
View directory record Official record
Conditions
Degenerative Spondylolisthesis
Interventions
ART352-L
Biological
Lead sponsor
Ankasa Regenerative Therapeutics, Inc.
Industry
Eligibility
50 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
3
States / cities
Los Angeles, California • Rochester, Minnesota • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 12, 2020 · Synced Oct 3, 2026, 6:56 PM EDT
Recruiting Not applicable Interventional

Function After Anterior Cervical Discectomy and Fusion Surgery: Timing of Physical Therapy

NCT06202443
View directory record Official record
Conditions
Cervical Spine Degeneration, ACDF Surgery
Interventions
Early PT, Delayed PT
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
4
States / cities
Honolulu, Hawaii • Nashville, Tennessee • Fort Sam Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 3, 2026, 6:56 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Open Access Database of Standing Full Body Radiographs in Asymptomatic Volunteers

NCT03076658
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Osteoarthritis, Spine
Interventions
EOS imaging
Radiation
Lead sponsor
University of Colorado, Denver
Other
Eligibility
21 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2031
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Oct 3, 2026, 6:56 PM EDT
Completed Not applicable Interventional

Telehealth Activity Intervention After Lumbar Spine Surgery

NCT04968821
View directory record Official record
Conditions
Spinal Degenerative Disorder
Interventions
Physical activity intervention, Usual care
Behavioral · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 29, 2024 · Synced Oct 3, 2026, 6:56 PM EDT
Completed No phase listed Observational Results available

Retrospective/Prospective Data Collection on the LDR ROIC Interbody Fusion Device With VerteBRIDGE Plating

NCT02104167
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
ROIC interbody cage with VerteBRIDGE plating
Device
Lead sponsor
LDR Spine USA
Industry
Eligibility
21 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
7
States / cities
Laguna Hills, California • Munster, Indiana • Baltimore, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 16, 2019 · Synced Oct 3, 2026, 6:56 PM EDT
Withdrawn Not applicable Interventional

Comparison of Three Approaches of Electrode Placement to Detect Changes in Motor Evoked Potentials During Spine Surgery

NCT05098431
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Stenosis, Spinal Curvatures, Spondylitis, Spondylosis
Interventions
Quadriceps and Rectus Femoris MEP Recording
Other
Lead sponsor
Allina Health System
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 12, 2024 · Synced Oct 3, 2026, 6:56 PM EDT
Completed Not applicable Interventional

A Clinical Study to Evaluate Safety and Performance of PEEK-OPTIMA™ HA Enhanced.

NCT04416321
View directory record Official record
Conditions
Degenerative Disc Disease, Spondylolisthesis, Retrolisthesis
Interventions
Surgery with the Keos Lumbar Interbody Fusion Device
Device
Lead sponsor
Invibio Ltd
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Lancaster, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 3, 2026, 6:56 PM EDT
Terminated No phase listed Observational

A Multicenter Prospective Registry for the Management of Degenerative Spine Disorders

NCT02802033
View directory record Official record
Conditions
Degenerative Diseases, Spinal Cord
Interventions
Not listed
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
18 Years and older
Enrollment
908 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
5
States / cities
Los Angeles, California • Atlanta, Georgia • Baltimore, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 3, 2026, 6:56 PM EDT
Recruiting Not applicable Interventional

Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion

NCT04679844
View directory record Official record
Conditions
Degenerative Disc Disease, Spine Fusion, Back Pain
Interventions
MagnetOs Easypack Putty, Demineralized Bone Matrix or Fibers mixed with local autograft bone
Device
Lead sponsor
Kuros Biosurgery AG
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
6
States / cities
Irvine, California • Grand Rapids, Michigan • St Louis, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2026 · Synced Oct 3, 2026, 6:56 PM EDT
Completed Not applicable Interventional Results available

Efficacy and Safety of Accell Evo3 Demineralized Bone Matrix (DBM) in Instrumented Posterolateral Lumbar Spine Fusion

NCT01430299
View directory record Official record
Conditions
Stenosis, Spondylosis, Degenerative Changes
Interventions
Demineralized Bone Matrix, rh-BMP2
Device
Lead sponsor
SeaSpine, Inc.
Industry
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2018 · Synced Oct 3, 2026, 6:56 PM EDT
Enrolling by invitation Phase 3 Interventional Accepts healthy volunteers

GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries

NCT05444751
View directory record Official record
Conditions
Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Radiculopathy
Interventions
General anesthetic, SA + ESP
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Oct 3, 2026, 6:56 PM EDT
Completed Not applicable Interventional Results available

Study of the Safety and Effectiveness of the Artificial Cervical Disc - Low Profile Device at Two Adjacent Levels

NCT00637156
View directory record Official record
Conditions
Cervical Degenerative Disc Disease, Radiculopathy, Myelopathy
Interventions
PRESTIGE LP device at two adjacent levels, Bi-level fusion with ATLANTIS Cervical Plate System
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
397 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2018
U.S. locations
29
States / cities
Huntsville, Alabama • Beverly Hills, California • Colton, California + 26 more
Source: ClinicalTrials.gov public record
Updated May 1, 2018 · Synced Oct 3, 2026, 6:56 PM EDT
Enrolling by invitation No phase listed Observational

Cervical Interbody Implant Study

NCT04689854
View directory record Official record
Conditions
Degenerative Disc Disease, Cervical Spinal Instability
Interventions
Not listed
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
7
States / cities
Orange, California • Hartford, Connecticut • Somerville, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 3, 2026, 6:56 PM EDT
Recruiting Not applicable Interventional

Evaluating the Efficacy of a Mobile Application in Postoperative Rehabilitation

NCT06407427
View directory record Official record
Conditions
Spine Degeneration, Hip Arthritis, Knee Osteoarthritis, Hip Fractures
Interventions
App for in-bed conditioning exercises, Usual care
Device · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 3, 2026, 6:56 PM EDT
Recruiting Not applicable Interventional

The NOTICE Study: Neurosurgery and OrThopedIcs Communication Evaluation Study Following Lumbar Fusions

NCT04140344
View directory record Official record
Conditions
Lumbar Spine Degeneration, Lumbar Spine Instability, Lumbar Spondylosis
Interventions
Text Message Group
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
224 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Oct 3, 2026, 6:56 PM EDT
Not yet recruiting No phase listed Observational

Assessing Safety of Cervical Spine Fusion With NMP®

NCT07245940
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis Cervical
Interventions
Natural Matrix Protein (NMP) Fibers, Cervical interbody fusion
Biological · Procedure
Lead sponsor
Red Rock Regeneration Inc.
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Jasper, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Oct 3, 2026, 6:56 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis

NCT00405691
View directory record Official record
Conditions
Low Back Pain, Leg Pain, Spondylolisthesis, Lumbar Spinal Stenosis
Interventions
"TOPS System" - Total Posterior Arthroplasty Implant
Device
Lead sponsor
Impliant, Ltd.
Industry
Eligibility
40 Years to 75 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2006
U.S. locations
16
States / cities
Beverly Hills, California • Daly City, California • New Haven, Connecticut + 12 more
Source: ClinicalTrials.gov public record
Updated May 18, 2011 · Synced Oct 3, 2026, 6:56 PM EDT
Not listed Not applicable Interventional

OSTEOAMP Lumbar Fusion Intra-Patient Controlled Study

NCT05405374
View directory record Official record
Conditions
Lumbar Spine Disease, Lumbar Spondylolisthesis, Lumbar Spine Instability, Lumbar Spondylosis, Degenerative Disc Disease
Interventions
OSTEOAMP, Infuse
Other · Device
Lead sponsor
Bioventus LLC
Industry
Eligibility
21 Years to 80 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
9
States / cities
New Haven, Connecticut • Wichita, Kansas • Paducah, Kentucky + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 28, 2023 · Synced Oct 3, 2026, 6:56 PM EDT
Terminated Not applicable Interventional

Study of the Effect of Neck Treatment on Shoulder Impingement

NCT00764764
View directory record Official record
Conditions
Shoulder Impingement, Shoulder Pain, Rotator Cuff Tendinitis, Cervical Degenerative Joint Disease
Interventions
shoulder treatment, Shoulder AND cervical treatment
Procedure
Lead sponsor
CAMC Health System
Other
Eligibility
40 Years to 70 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 3, 2026, 6:56 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Tissue Collection for Understanding Intervertebral Disc Degeneration and Back Pain

NCT01633034
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Back Pain
Interventions
Not listed
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2025
U.S. locations
2
States / cities
Manhasset, New York • Manhattan, New York
Source: ClinicalTrials.gov public record
Updated Mar 20, 2024 · Synced Oct 3, 2026, 6:56 PM EDT
Recruiting Not applicable Interventional

The Ailliance Post-Market Clinical Study

NCT05856370
View directory record Official record
Conditions
Spinal Deformity, Spinal Degenerative Disorder, Spinal Fusion Failure, Spinal Trauma, Spinal Tumor Case
Interventions
Follow-up schedule: pre-operative baseline up to 24-months post-procedure
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2031
U.S. locations
23
States / cities
Tucson, Arizona • Little Rock, Arkansas • Sacramento, California + 19 more
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 3, 2026, 6:56 PM EDT
Completed Phase 4 Interventional Results available

A Randomized Trial of Exparel vs Saline in Opioid Reduction of Pain Management Following Lumbar Spine Surgeries.

NCT04644796
View directory record Official record
Conditions
Lumbar Spine Degeneration
Interventions
saline 0.9%, Liposomal bupivacaine
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 13, 2023 · Synced Oct 3, 2026, 6:56 PM EDT
Not listed Phase 3 Interventional

Wallis Mechanical Normalization System for Low Back Pain

NCT00134537
View directory record Official record
Conditions
Low Back Pain
Interventions
Interspinous process and dynamic stabilization, Conservative Care
Device
Lead sponsor
Zimmer Spine
Industry
Eligibility
18 Years to 60 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2012
U.S. locations
17
States / cities
Phoenix, Arizona • Beverly Hills, California • Santa Monica, California + 13 more
Source: ClinicalTrials.gov public record
Updated Oct 4, 2011 · Synced Oct 3, 2026, 6:56 PM EDT