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Showing 1–24 of 27 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Spontaneous Ventilation Clear all
Completed No phase listed Observational

Weaning And Variability Evaluation

NCT01237886
View directory record Official record
Conditions
Mechanically Ventilated Patients, Extubation
Interventions
Not listed
Lead sponsor
Ottawa Hospital Research Institute
Other
Eligibility
18 Years and older
Enrollment
660 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
7
States / cities
Ann Arbor, Michigan • Billings, Montana • Lebanon, New Hampshire + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 6, 2017 · Synced Sep 5, 2026, 2:12 PM EDT
Terminated Not applicable Interventional

Extubation Readiness Study in Very Low Birthweight Infants

NCT01471431
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
spontaneous breathing trial
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
48 Hours to 14 Weeks
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
Phialdelphia, Pennsylvania • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 6, 2016 · Synced Sep 5, 2026, 2:12 PM EDT
Completed Not applicable Interventional Results available

Aerosol Particle Concentrations Among Different Oxygen Devices for Spontaneous Breathing Patients With Tracheostomy

NCT04654754
View directory record Official record
Conditions
Transmission, Patient-Professional
Interventions
high-flow high humidity oxygen device with tracheostomy adapter
Device
Lead sponsor
Jie Li
Other
Eligibility
18 Years to 90 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 20, 2022 · Synced Sep 5, 2026, 2:12 PM EDT
Not listed Not applicable Interventional

The Frequency of Screening and SBT Technique Trial: The FAST Trial

NCT02969226
View directory record Official record
Conditions
Critically Ill
Interventions
Once daily screening, Twice daily screening, PS SBTs, T-piece SBTs
Procedure
Lead sponsor
Unity Health Toronto
Other
Eligibility
16 Years and older
Enrollment
760 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
5
States / cities
Long Beach, California • Los Angeles, California • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 4, 2018 · Synced Sep 5, 2026, 2:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

EIT Assessment of Lung Volume and Tidal Distribution: A Comparison of Non-Invasive Ventilation Devices

NCT02930174
View directory record Official record
Conditions
Spontaneous Ventilation
Interventions
noninvasive positive pressure ventilation
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 13, 2019 · Synced Sep 5, 2026, 2:12 PM EDT
Completed No phase listed Observational

Mechanical Ventilation Discontinuation Practices

NCT03955874
View directory record Official record
Conditions
Invasive Mechanical Ventilation, Critical Illness, Spontaneous Breathing Trial, Weaning Invasive Mechanical Ventilation, Tracheostomy, Direct Extubation
Interventions
Not listed
Lead sponsor
Unity Health Toronto
Other
Eligibility
16 Years and older
Enrollment
1,868 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
2
States / cities
Boston, Massachusetts • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 1, 2021 · Synced Sep 5, 2026, 2:12 PM EDT
Recruiting Not applicable Interventional

Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults

NCT07005505
View directory record Official record
Conditions
Spontaneous Breathing Trial in ICU
Interventions
Pressure Support Ventilation (PSV), Automatic tube compensation (ATC)
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
880 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Sep 5, 2026, 2:12 PM EDT
Completed No phase listed Observational

Awakening-Breathing Coordination, Delirium Monitoring/Management & Early Mobility (ABCDE) Protocol

NCT01413009
View directory record Official record
Conditions
ICU Delirium, Immobility
Interventions
Not listed
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 14, 2023 · Synced Sep 5, 2026, 2:12 PM EDT
Completed Not applicable Interventional Results available

The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures

NCT01969227
View directory record Official record
Conditions
Mechanical Ventilation, Airway Patency, Respiratory Depression
Interventions
Subanesthetic ketamine
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 5, 2026, 2:12 PM EDT
Completed Not applicable Interventional Results available

Comparison Between Two Methods of Spontaneous Breathing Trial (SBT)

NCT00400881
View directory record Official record
Conditions
Respiratory Failure
Interventions
automatic tube compensation
Other
Lead sponsor
Texas Tech University Health Sciences Center, El Paso
Other
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Jun 8, 2017 · Synced Sep 5, 2026, 2:12 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of PEEP on Heart and Lungs in Obese Subjects

NCT02523352
View directory record Official record
Conditions
Obesity, Pulmonary Atelectasis, Obesity Hypoventilation Syndrome, Magnetic Resonance Imaging, Respiratory Mechanics, Electrical Impedance Tomography, Trans-Thoracic Echocardiography
Interventions
Non-Invasive Ventilation, Esophageal catheter positioning
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 16, 2020 · Synced Sep 5, 2026, 2:12 PM EDT
Terminated Phase 2 Interventional Results available

Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID-19

NCT04305457
View directory record Official record
Conditions
Coronavirus Infections, Pneumonia, Viral, Acute Respiratory Distress Syndrome
Interventions
Nitric Oxide
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
Shreveport, Louisiana • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced Sep 5, 2026, 2:12 PM EDT
Terminated Not applicable Interventional

Sedation Versus No Sedation in a Spontaneous Breathing Trial

NCT00366353
View directory record Official record
Conditions
Respiratory Insufficiency
Interventions
Sedation during SBT, No sedation
Other
Lead sponsor
Memorial Medical Center
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Johnstown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 17, 2015 · Synced Sep 5, 2026, 2:12 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Respiration Rate Monitoring During Transitions

NCT01881269
View directory record Official record
Conditions
Focus of the Study is Measuring Respiratory Rate
Interventions
Not listed
Lead sponsor
Medtronic - MITG
Industry
Eligibility
18 Years to 65 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 5, 2013 · Synced Sep 5, 2026, 2:12 PM EDT
Not yet recruiting Not applicable Interventional

PRECISION-CPR: PRecision-Controlled Ventilation in CPR

NCT07088120
View directory record Official record
Conditions
Cardiac Arrest (CA)
Interventions
Precision-Controlled Ventilation with Real-Time Feedback, Standard Manual Ventilation During CPR
Device · Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
852 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Sep 5, 2026, 2:12 PM EDT
Recruiting Not applicable Interventional

Telehealth-Enabled, Real-time Audit and Feedback for Clinician AdHerence (TEACH)

NCT05141396
View directory record Official record
Conditions
Respiration, Artificial
Interventions
Telehealth- enabled support for SAT/SBT adherence, Usual audit and feedback for SAT/SBT adherence
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
16 Years and older
Enrollment
13,400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
11
States / cities
American Fork, Utah • Cedar City, Utah • Layton, Utah + 8 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2023 · Synced Sep 5, 2026, 2:12 PM EDT
Terminated No phase listed Observational

Synchronized Intermittent Mechanical Ventilation Versus Open Lung Ventilation With Spontaneous Respiration

NCT00891085
View directory record Official record
Conditions
Trauma
Interventions
Not listed
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Sep 5, 2026, 2:12 PM EDT
Withdrawn No phase listed Observational

Electrocardiographic Autonomic Function Measures in Mechanically Ventilated Patients

NCT00844935
View directory record Official record
Conditions
Disorders of the Autonomic Nervous System, Cardiovascular Abnormalities, Respiratory Disorders
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 27, 2012 · Synced Sep 5, 2026, 2:12 PM EDT
Not listed Not applicable Interventional

Frequency of Screening and SBT Technique Trial

NCT02399267
View directory record Official record
Conditions
Critically Ill
Interventions
Once daily screening, Twice daily screening, PS SBTs, T-piece SBTs
Procedure
Lead sponsor
Unity Health Toronto
Other
Eligibility
16 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
2
States / cities
Long Beach, California • Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 3, 2019 · Synced Sep 5, 2026, 2:12 PM EDT
Terminated Not applicable Interventional

Feasibility of Music Therapy for Spontaneous Breathing Trials

NCT05008328
View directory record Official record
Conditions
Spontaneous Breathing Trial, Intubation, Mechanical Ventilation, Music Therapy
Interventions
Music therapy plus standard care during an SBT, Standard care during an SBT
Other · Procedure
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Sep 5, 2026, 2:12 PM EDT
Completed Not applicable Interventional

PAV vs Assist Control After Failed SBT

NCT02773433
View directory record Official record
Conditions
Weaning Mode Comparison
Interventions
Proportional Assist Ventilation
Other
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 6, 2016 · Synced Sep 5, 2026, 2:12 PM EDT
Withdrawn Phase 4 Interventional

Automated Ventilator Controlled Weaning vs Daily Spontaneous Breathing Trial in Difficult to Wean ICU Patients

NCT00813839
View directory record Official record
Conditions
Mechanical Ventilation, Weaning
Interventions
daily weaning trails
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 7, 2015 · Synced Sep 5, 2026, 2:12 PM EDT
Completed No phase listed Observational

Diaphragm Ultrasound Measurements With Variations in Modes of Ventilation

NCT04319939
View directory record Official record
Conditions
Mechanical Ventilation
Interventions
Assist Control Mode and Pressure Support Mode Mechanical Ventilation
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
66 participants
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 25, 2025 · Synced Sep 5, 2026, 2:12 PM EDT