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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Sprain Clear all
Completed Phase 3 Interventional Results available

Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Applied 4 Times Daily in Subjects With Acute Ankle Sprain

NCT01255423
View directory record Official record
Conditions
Ankle Sprain
Interventions
Diclofenac sodium topical gel 1%, Placebo
Drug
Lead sponsor
Novartis
Industry
Eligibility
18 Years and older
Enrollment
206 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
9
States / cities
Birmingham, Alabama • Aventura, Florida • Hialeah, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 3, 2012 · Synced Jul 22, 2026, 1:56 AM EDT
Completed Not applicable Interventional

Telehealth Delivered Physical Rehabilitation for an Ankle Sprain

NCT04520854
View directory record Official record
Conditions
Ankle Sprains, Telerehabilitation, Analgesic, Opioid, Analgesics, Non-narcotic, Anti-Inflammatory Agents, Non-Steroidal, Implementation Science, Acute Pain, Quality of Life
Interventions
Telehealth Protocol, Usual Care
Other
Lead sponsor
Kyle Kosik
Other
Eligibility
15 Years to 35 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 27, 2025 · Synced Jul 22, 2026, 1:56 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

ATI Evidence-based Guide Investigating Medical and Preventative Services

NCT04050319
View directory record Official record
Conditions
Sport Medicine
Interventions
Screening and diagnosis if injured
Diagnostic Test
Lead sponsor
ATI Holdings, LLC
Industry
Eligibility
Not listed
Enrollment
550,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Downers Grove, Illinois
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Jul 22, 2026, 1:56 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Research Protocol for Karuna Labs Inc.: Safety and Efficacy of Virtual Reality Graded Motor Imagery for Chronic Pain

NCT04060875
View directory record Official record
Conditions
Chronic Pain, Low Back Pain, Fibromyalgia, Upper Extremity Dysfunction, Complex Regional Pain Syndromes, Phantom Limb Pain, Rheumatoid Arthritis, Carpal Tunnel Syndrome, Repetitive Strain Injury
Interventions
Karuna Labs Virtual Reality Software
Device
Lead sponsor
Karuna Labs Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2021 · Synced Jul 22, 2026, 1:56 AM EDT
Completed Not applicable Interventional

Effect of Lumbrical Stretching on Carpal Tunnel Syndrome

NCT00803257
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Lumbrical splint and Lumbrical exercises
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 12, 2012 · Synced Jul 22, 2026, 1:56 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Wound Closure Study in Carpal Tunnel and Trigger Finger Surgery

NCT03781141
View directory record Official record
Conditions
Carpal Tunnel Syndrome, Trigger Finger
Interventions
Wound closure
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Jul 22, 2026, 1:56 AM EDT
Not listed Phase 4 Interventional

A Comparison of Ultrasound-guided Steroid Injection With Wrist Splint in Carpal Tunnel Syndrome

NCT04515966
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Methylprednisolone Injection [Solu-Medrol], wrist splint
Drug · Device
Lead sponsor
Mercy Health Ohio
Other
Eligibility
18 Years to 75 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Boardman, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 8, 2021 · Synced Jul 22, 2026, 1:56 AM EDT
Completed Not applicable Interventional

Cognitive Behavioral Based Physical Therapy for Patients With Chronic Ankle Instability

NCT07237581
View directory record Official record
Conditions
Ankle Sprains, Chronic Ankle Instability
Interventions
CBPT/HEP, HEP Only
Behavioral
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 35 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Jul 22, 2026, 1:56 AM EDT
Completed Phase 3 Interventional Results available

5% Topical Ibuprofen (IBU) for Ankle Sprain

NCT01945034
View directory record Official record
Conditions
Ankle Injuries
Interventions
Topical IBU twice daily, Placebo twice daily, Topical IBU three times daily, Placebo three times daily
Drug
Lead sponsor
Pfizer
Industry
Eligibility
12 Years and older
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
19
States / cities
Sheffield, Alabama • Tucson, Arizona • Anaheim, California + 11 more
Source: ClinicalTrials.gov public record
Updated May 25, 2016 · Synced Jul 22, 2026, 1:56 AM EDT
Completed Not applicable Interventional

Use of Human Dehydrated Umbilical Cord Allograft in Supraspinatus Tendon Repair

NCT03084068
View directory record Official record
Conditions
Shoulder Injury, Shoulder Sprain, Supraspinatus Tear
Interventions
Human dehydrated umbilical cord allograft, Placebo
Other
Lead sponsor
MiMedx Group, Inc.
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Wexford, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Jul 22, 2026, 1:56 AM EDT
Completed Phase 4 Interventional Results available

Preoperative Antibiotics for Carpal Tunnel Release Surgery

NCT03432858
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Vancomycin, Cefazolin, Saline Solution
Drug
Lead sponsor
WellSpan Health
Other
Eligibility
18 Years and older
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
York, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 9, 2021 · Synced Jul 22, 2026, 1:56 AM EDT
Terminated No phase listed Observational

Corticosteroid Injection as a Predictor of Outcome in Carpal Tunnel Release

NCT00655915
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Corticosteroid Injection- 1ml of Betamethasone and 1 ml of 1% Lidocaine
Other
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 8, 2011 · Synced Jul 22, 2026, 1:56 AM EDT
Completed Not applicable Interventional

Use of Platelet Rich Plasma Therapy for Acute Ankle Sprains in the Emergency Department

NCT01518335
View directory record Official record
Conditions
Sprain of Ankle
Interventions
Platelet rich plasma injection, Placebo Comparator: Placebo/Standard of Care
Procedure
Lead sponsor
Albert Einstein Healthcare Network
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 9, 2017 · Synced Jul 22, 2026, 1:56 AM EDT
Terminated Not applicable Interventional

Comparative Study of Two Incision vs. Mini Open Carpal Tunnel Release

NCT05325567
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Mini open incision CTR
Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 17, 2023 · Synced Jul 22, 2026, 1:56 AM EDT
Completed Not applicable Interventional

Resident Posture Biofeedback Study

NCT06564519
View directory record Official record
Conditions
Postural; Strain, Healthy
Interventions
Posture Biofeedback Device
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Jul 22, 2026, 1:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study Investigating The Effects Of An Ankle Rehabilitation Program On High School Athletes With Ankle Instability

NCT03447652
View directory record Official record
Conditions
Chronic Ankle Instability, Ankle Sprains, Ankle Rehabilitation
Interventions
Resistance Band Ankle Rehabilitation, Biomechanical Ankle Platform System Rehabilitation, Combination Rehabilitation
Other
Lead sponsor
Georgia State University
Other
Eligibility
15 Years to 18 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
7
States / cities
Atlanta, Georgia • College Park, Georgia • Decatur, Georgia + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2018 · Synced Jul 22, 2026, 1:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nylon Versus Chromic Gut Sutures for Minor Hand Surgery

NCT03407820
View directory record Official record
Conditions
All Minor Hand Surgery Including, Carpal Tunnel Syndrome, Trigger Finger, Ganglion Cysts, De Quervain Syndrome, Dupuytren Contracture
Interventions
Absorbable Chromic gut sutures, Non-absorbable Nylon sutures
Procedure
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 89 Years
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
3
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Jul 22, 2026, 1:56 AM EDT
Completed Phase 4 Interventional

A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions

NCT00904202
View directory record Official record
Conditions
Postherpetic Neuralgia, Diabetic Neuropathy, Complex Regional Pain Syndrome, Carpal Tunnel Syndrome, HIV Neuropathy, Idiopathic Sensory Neuropathy, Peripheral Neuropathy
Interventions
Placebo Capsules + Placebo Patch, Placebo capsules + Lidoderm®, Gabapentin + Placebo, Gabapentin + Lidoderm®, Gabapentin 300 mg capsules 1800 mg/day + placebo patch, Gabapentin 1800 mg/day + Lidoderm patch
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2003
U.S. locations
7
States / cities
Birmingham, Alabama • Hueytown, Alabama • Phoenix, Arizona + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 1, 2024 · Synced Jul 22, 2026, 1:56 AM EDT
Completed Not applicable Interventional

External Versus Internal Feedback in Patients With Chronic Ankle Instability

NCT04131842
View directory record Official record
Conditions
Ankle Injuries, Ankle Inversion Sprain
Interventions
External focus of attention visual feedback, External focus of attention auditory feedback, Internal focus of attention video feedback, No feedback
Other
Lead sponsor
University of North Carolina, Charlotte
Other
Eligibility
18 Years to 40 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 18, 2024 · Synced Jul 22, 2026, 1:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Strength Training on Musculoskeletal Overuse Injuries in Female Runners

NCT03080246
View directory record Official record
Conditions
Overuse Injury
Interventions
Strength Training Exercise
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 11, 2020 · Synced Jul 22, 2026, 1:56 AM EDT
Recruiting Not applicable Interventional

Addressing Neuromuscular Deficits for Improved Outcomes in Ankle Rehabilitation

NCT03663361
View directory record Official record
Conditions
Ankle Sprains
Interventions
SMART Intervention, Standard of Care Intervention
Other
Lead sponsor
Phillip Gribble
Other
Eligibility
18 Years to 44 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
2
States / cities
Lexington, Kentucky • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Jul 22, 2026, 1:56 AM EDT
Completed Phase 3 Interventional

HKT-500 in Adult Patients With Ankle Sprain

NCT00680784
View directory record Official record
Conditions
Ankle Sprain
Interventions
HKT-500 Ketoprofen Topical Patch, Placebo Patch
Drug · Other
Lead sponsor
Hisamitsu Pharmaceutical Co., Inc.
Industry
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
30
States / cities
Birmingham, Alabama • Montgomery, Alabama • Anaheim, California + 26 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2015 · Synced Jul 22, 2026, 1:56 AM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers

NeuroPath Comparative Validation Study Plan

NCT00393549
View directory record Official record
Conditions
Carpal Tunnel Syndrome (CTS)
Interventions
NeuroPath
Device
Lead sponsor
Excel-Tech Ltd.
Industry
Eligibility
18 Years to 75 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
2
States / cities
Dothan, Alabama • St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Jun 5, 2007 · Synced Jul 22, 2026, 1:56 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Safety and Efficacy of Generic Diclofenac Epolamine Acute Pain Due to Minor Ankle Sprain

NCT02324270
View directory record Official record
Conditions
Ankle Sprain
Interventions
Diclofenac epolamine, Placebo
Drug · Other
Lead sponsor
Actavis Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
658 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
31
States / cities
Birmingham, Alabama • Goodyear, Arizona • Carlsbad, California + 26 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2020 · Synced Jul 22, 2026, 1:56 AM EDT