Independent directory Public ClinicalTrials.gov records United States
Clinical Trials Finder
Objective public record navigation
Search Results

Search by objective public record fields.

Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results are retrieved from ClinicalTrials.gov and synchronized into the directory. Search pages remain noindex by default.

Clear filters
ClinicalTrials.gov public records Last synced Sep 27, 2026, 4:35 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Sprain of Ankle Clear all
Suspended Not applicable Interventional Accepts healthy volunteers

Enovis High Ankle Sprain Brace Testing

NCT06719609
View directory record Official record
Conditions
Athletes in Cutting Sports
Interventions
Ankle tape, Standard lace-up ankle brace, Standard high ankle-sprain (HAS) brace, Low-profile HAS brace, No ankle brace or tape
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 27, 2026, 4:35 PM EDT
Completed No phase listed Observational

Grappler® Interference Screw Post-Market Clinical Follow-Up Study

NCT04893824
View directory record Official record
Conditions
Ankle Injuries, Syndesmotic Injuries, Ankle Inversion Sprain, Deltoid Ankle Sprain, Achilles Tendon Rupture, Flexor Hallucis Longus on the Left, Flexor Digitorum Longus on the Left, Ankle Sprains, Flexor Hallucis Longus on the Right, Flexor Digitorum Longus on the Right
Interventions
Grappler® Interference Screw System
Device
Lead sponsor
Paragon 28
Industry
Eligibility
Not listed
Enrollment
50 participants
Timeline
2021 – 2022
U.S. locations
1
States / cities
Worthington, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 14, 2023 · Synced Sep 27, 2026, 4:35 PM EDT
Withdrawn Not applicable Interventional

Efficacy of PENNSAID® for Pain Management in the Emergency Department

NCT01350622
View directory record Official record
Conditions
Pain, Ankle Sprain
Interventions
PENNSAID, Diclofenac hydroxyethylpyrrolidine
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 20, 2016 · Synced Sep 27, 2026, 4:35 PM EDT
Not listed Not applicable Interventional

Effects of Talocrural Joint Mobilizations in the Treatment of Subacute Lateral Ankle Sprains

NCT01117909
View directory record Official record
Conditions
Ankle Sprain
Interventions
Mobilization therapy in addition to standard therapy, Sham intervention
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 29, 2011 · Synced Sep 27, 2026, 4:35 PM EDT
Terminated Not applicable Interventional

Effectiveness of Transcranial Direct Current Stimulation (tDCS).

NCT04902274
View directory record Official record
Conditions
Ankle Sprains, Musculoskeletal Injury
Interventions
Transcranial Direct Current Stimulation, Sham Transcranial Direct Current Stimulation, Physical Therapy
Other
Lead sponsor
Keller Army Community Hospital
Federal
Eligibility
18 Years to 40 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
West Point, New York
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Sep 27, 2026, 4:35 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of SST 0225, a Topical Ibuprofen Cream, in the Treatment of Pain Associated With Acute Ankle Sprain

NCT01874626
View directory record Official record
Conditions
Acute Ankle Sprain
Interventions
Placebo, SST-0225 Topical Ibuprofen Cream
Drug
Lead sponsor
Strategic Science & Technologies, LLC
Industry
Eligibility
16 Years and older
Enrollment
305 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Guilford, Connecticut
Source: ClinicalTrials.gov public record
Updated May 20, 2021 · Synced Sep 27, 2026, 4:35 PM EDT
Recruiting Not applicable Interventional

Semiconductor Embedded Socks for Ankle Sprains

NCT07025733
View directory record Official record
Conditions
Ankle Sprain
Interventions
Semiconductor Embedded Sock, Control Compression Sock
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 27, 2026, 4:35 PM EDT
Withdrawn Not applicable Interventional

The Effect of Low-Intensity Blood Flow Restriction Therapy on the Management of Acute Ankle Sprains

NCT05596162
View directory record Official record
Conditions
Ankle Sprain 1St Degree, Ankle Sprain 2Nd Degree, Musculoskeletal Injury
Interventions
Blood Flow Restriction Therapy, Standard Physical Therapy
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 27, 2025 · Synced Sep 27, 2026, 4:35 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Ankle Sprain or Strain

NCT00351104
View directory record Official record
Conditions
Sprain, Strain
Interventions
Ketoprofen Topical Patch 20%
Drug
Lead sponsor
APR Applied Pharma Research s.a.
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Sep 27, 2026, 4:35 PM EDT
Completed Phase 3 Interventional

MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Ankle Sprains

NCT01198834
View directory record Official record
Conditions
Ankle Sprains
Interventions
MRX-7EAT, Placebo, Lidocaine, Etodolac
Drug
Lead sponsor
MEDRx USA, Inc.
Industry
Eligibility
14 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
33
States / cities
Phoenix, Arizona • North Little Rock, Arkansas • Chico, California + 30 more
Source: ClinicalTrials.gov public record
Updated Jan 16, 2018 · Synced Sep 27, 2026, 4:35 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Multisegmented Foot Motion in Patients With Lateral Ankle Sprains and Chronic Ankle Instability

NCT02697461
View directory record Official record
Conditions
Injuries, Ankle, Sprain of Foot
Interventions
Intrinsic Foot Strengthening, Joint Mobilization
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 2, 2017 · Synced Sep 27, 2026, 4:35 PM EDT
Completed Phase 1Phase 2 Interventional

Ankle Sprains and Corticospinal Excitability

NCT00847769
View directory record Official record
Conditions
Ankle Sprain
Interventions
High velocity, low amplitude stretch, Slow, mobilization stretch, Passive Positioning
Other
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 60 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 3, 2017 · Synced Sep 27, 2026, 4:35 PM EDT
Completed Phase 3 Interventional Results available

5% Topical Ibuprofen (IBU) for Ankle Sprain

NCT01945034
View directory record Official record
Conditions
Ankle Injuries
Interventions
Topical IBU twice daily, Placebo twice daily, Topical IBU three times daily, Placebo three times daily
Drug
Lead sponsor
Pfizer
Industry
Eligibility
12 Years and older
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
19
States / cities
Sheffield, Alabama • Tucson, Arizona • Anaheim, California + 11 more
Source: ClinicalTrials.gov public record
Updated May 25, 2016 · Synced Sep 27, 2026, 4:35 PM EDT
Recruiting Not applicable Interventional

A Proprioceptive Training Program Using an Uneven Terrain Treadmill for Patients With Ankle Instability

NCT04999904
View directory record Official record
Conditions
Instability; Ankle (Ligaments) (Old Injury), Sprain of Ankle
Interventions
Uneven Treadmill Intervention, Standard of Care Physical Therapy
Other
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 49 Years
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Oceanside, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Sep 27, 2026, 4:35 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Safety and Efficacy of Generic Diclofenac Epolamine Acute Pain Due to Minor Ankle Sprain

NCT02324270
View directory record Official record
Conditions
Ankle Sprain
Interventions
Diclofenac epolamine, Placebo
Drug · Other
Lead sponsor
Actavis Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
658 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
31
States / cities
Birmingham, Alabama • Goodyear, Arizona • Carlsbad, California + 26 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2020 · Synced Sep 27, 2026, 4:35 PM EDT
Not listed Not applicable Interventional

The Effects of Gentle Movements at the Ankle in Individuals With Diminished Range of Motion

NCT01119092
View directory record Official record
Conditions
Lateral Ankle Sprain
Interventions
Sham ("laying of hands") intervention, Grade IV AP joint mobilizations
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 29, 2011 · Synced Sep 27, 2026, 4:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Progressing Ankle Brace Restriction on Walking and Running Gait Characteristics in Healthy Individuals

NCT03641066
View directory record Official record
Conditions
Ankle Sprains
Interventions
Ankle Brace
Device
Lead sponsor
Sport and Spine Rehab Clinical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 24, 2019 · Synced Sep 27, 2026, 4:35 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Mobilization in Conjunction With Exercise in Participants With a History of Chronic Ankle Instability

NCT03428620
View directory record Official record
Conditions
Ankle Sprains
Interventions
High Velocity Low Amplitude mobilization, Exercise protocol
Other
Lead sponsor
Shenandoah University
Other
Eligibility
18 Years to 35 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
2
States / cities
Fayetteville, North Carolina • Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 16, 2018 · Synced Sep 27, 2026, 4:35 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

The Effect of Strain-counterstrain on Ankle Instability

NCT02025569
View directory record Official record
Conditions
Other Instability, Ankle and Foot
Interventions
Strain Counterstrain, Sham strain counterstrain
Other
Lead sponsor
Long Island University
Other
Eligibility
18 Years to 55 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Dec 31, 2013 · Synced Sep 27, 2026, 4:35 PM EDT
Withdrawn Not applicable Interventional

Waterproof Casting Versus Standard Casting for Short Leg Walking Casts

NCT04961957
View directory record Official record
Conditions
Ankle Fractures, Foot Fracture, Ankle Sprains, Foot Sprain, Toe-walking, Tendonitis of Foot, Apophysitis; Juvenile
Interventions
Waterproof padding, Non-waterproof padding
Device
Lead sponsor
West Virginia University
Other
Eligibility
5 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Sep 7, 2025 · Synced Sep 27, 2026, 4:35 PM EDT
Terminated Phase 2 Interventional Results available

Investigation of Corticosteroid Versus Placebo Injection in Patients With Syndesmotic Ligament Injury or High Ankle Sprain

NCT02892500
View directory record Official record
Conditions
Ankle Injuries
Interventions
bupivacaine hydrochloride and betamethasone sodium phosphate, bupivacaine hydrochloride
Drug
Lead sponsor
Sanford Health
Other
Eligibility
16 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Feb 12, 2024 · Synced Sep 27, 2026, 4:35 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Mobilization Versus Manipulation on Function in Participants Reporting CAI

NCT03918473
View directory record Official record
Conditions
Ankle Sprains
Interventions
Mobilization with Movement, Thrust Mobilization
Other
Lead sponsor
Shenandoah University
Other
Eligibility
18 Years to 35 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 16, 2019 · Synced Sep 27, 2026, 4:35 PM EDT
Terminated Phase 3 Interventional

An Efficacy and Safety Study for the Treatment of Mild to Moderate Acute Pain Associated With Ankle Strain or Sprain.

NCT02089425
View directory record Official record
Conditions
Acute Pain From Ankle Sprain or Strain
Interventions
K-103-IP, Placebo
Drug
Lead sponsor
Kowa Research Institute, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
384 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
47
States / cities
Birmingham, Alabama • Phoenix, Arizona • Tempe, Arizona + 44 more
Source: ClinicalTrials.gov public record
Updated Mar 2, 2017 · Synced Sep 27, 2026, 4:35 PM EDT
Not yet recruiting No phase listed Observational Accepts healthy volunteers

Validation of a Portable Ankle Arthrometer

NCT07163897
View directory record Official record
Conditions
Chronic Ankle Instability, CAI, Ankle Sprain, Healthy
Interventions
Cobra Ankle Arthrometer
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 40 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Sep 27, 2026, 4:35 PM EDT