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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Staining Clear all
Completed Phase 4 Interventional Accepts healthy volunteers

Comparison of Two Multi-Purpose Solution and Lens Material Combinations on Corneal Barrier Function

NCT00560898
View directory record Official record
Conditions
Contact Lens Disinfecting Solutions
Interventions
ProClear Lens Material soaked in ReNu Multiplus Multipurpose Solution, Acuvue Advance Lens Material soaked in ReNu Multiplus Multipurpose Solution, Acuvue Advance Lens Material soaked in Optifree RepleniSH Multipurpose Solution, ProClear Lens Material soaked in Optifree RepleniSH Multipurpose Solution
Drug
Lead sponsor
Southern California College of Optometry at Marshall B. Ketchum University
Other
Eligibility
18 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Fullerton, California
Source: ClinicalTrials.gov public record
Updated May 19, 2008 · Synced Jul 23, 2026, 2:11 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Investigating Oral Agents for Urine Staining to Facilitate Intraoperative Observation of Ureteral Jets

NCT03432572
View directory record Official record
Conditions
Ureteral Injury
Interventions
Pyridium, Riboflavin, Thiamine
Drug
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
21 Years to 75 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Aug 10, 2020 · Synced Jul 23, 2026, 2:11 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Optical Biopsy of Human Skin in Conjunction With Laser Treatment

NCT00540566
View directory record Official record
Conditions
Malignant Melanoma, Merkel Cell Carcinoma, Basal Cell Carcinoma, Squamous Cell Carcinoma, Atypical Nevi, Congenital Nevi, Seborrheic Keratosis, Paget's Disease, Dermatofibroma, Kaposi's Sarcoma, Port Wine Stain, Hemangioma, Tattoos, Scleroderma, Burns
Interventions
Optical Biopsy imaging
Device
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 75 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2008
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Jul 23, 2026, 2:11 AM EDT
Completed Not applicable Interventional

Sponge and Eosinophil Peroxidase (EPO) Staining

NCT03078023
View directory record Official record
Conditions
Eosinophilic Esophagitis
Interventions
swallowed sponge device
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 14, 2022 · Synced Jul 23, 2026, 2:11 AM EDT
Recruiting Phase 2 Interventional

A Study to Evaluate Efficacy and Safety of Light Dose in Subjects With PWB Treated With Hemoporfin PDT

NCT05171894
View directory record Official record
Conditions
Port-wine Birthmarks, Port-Wine Stain, Nevus Flammeus
Interventions
Hemopfin+Green Light, Vehicle+Green Light
Drug · Device
Lead sponsor
Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.
Industry
Eligibility
18 Years to 75 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
5
States / cities
Irvine, California • San Diego, California • Miami, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jul 23, 2026, 2:11 AM EDT
Completed Phase 1 Interventional

A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks.

NCT00800722
View directory record Official record
Conditions
Port Wine Stain
Interventions
Rapamycin Treatment of Port Wine Stain
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Oct 31, 2022 · Synced Jul 23, 2026, 2:11 AM EDT
Completed No phase listed Observational

Soft Contacts Observation of Risk and Education (SCORE)

NCT03305484
View directory record Official record
Conditions
Contact Lens Complication, Contact Lens Acute Red Eye, Contact Lens Related Corneal Infiltrate (Disorder), Contact Lens-Induced Corneal Fluorescein Staining
Interventions
No intervention
Other
Lead sponsor
Southern California College of Optometry at Marshall B. Ketchum University
Other
Eligibility
18 Years to 39 Years
Enrollment
171 participants
Timeline
2017 – 2019
U.S. locations
4
States / cities
Fullerton, California • Fort Lauderdale, Florida • Columbus, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 17, 2019 · Synced Jul 23, 2026, 2:11 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Dynamic Epidermal Cooling During Pulsed Dye Laser Treatment of Port Wine Stain Birthmark at High Fluences

NCT00540371
View directory record Official record
Conditions
Port Wine Stain
Interventions
Port wine stain Birthmark
Other
Lead sponsor
University of California, Irvine
Other
Eligibility
1 Month to 75 Years
Enrollment
136 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2009
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Jul 23, 2026, 2:11 AM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

The Study of Folate Receptor-Mediated Staining Solution (FRD™) In Cervical Lesion Detection

NCT03366493
View directory record Official record
Conditions
Cervical Intraepithelial Neoplasia Grade 2/3
Interventions
FRD, Cytology, HPV testing, Colposcopy, ECC, Biospy
Combination Product · Other · Procedure
Lead sponsor
GY Highland Biotech LLC
Industry
Eligibility
20 Years to 60 Years · Female only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 7, 2017 · Synced Jul 23, 2026, 2:11 AM EDT
Recruiting Not applicable Interventional

Maximizing Laser Therapy Success for Port-Wine Birthmarks in Pediatric Patients

NCT07183644
View directory record Official record
Conditions
Port Wine Stains
Interventions
Pulse Dye laser, Pulse Dye Laser (PDL) pulse width stacking, Pulse Dye Laser (PDL) followed by Nd:YAG (Neodymium-doped Yttrium Aluminum Garnet laser) laser., IPL (Intense Pulsed Light) followed by Pulse Dye Laser (PDL), Cupping followed by Pulse Dye Laser (PDL)
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
2 Months to 18 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Dallas, Texas • Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jul 23, 2026, 2:11 AM EDT
Completed No phase listed Observational

Food Antigen in Eosinophilic Esophagitis

NCT02434705
View directory record Official record
Conditions
Eosinophilic Esophagitis
Interventions
Antigen (wheat base soy sauce) spray
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 11, 2023 · Synced Jul 23, 2026, 2:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy of the ToothWave Power Toothbrush for Extrinsic Stain Reduction

NCT03885609
View directory record Official record
Conditions
Tooth Discoloration
Interventions
ToothWave, powered toothbrush
Device
Lead sponsor
Home Skinovations Ltd.
Industry
Eligibility
18 Years to 70 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 9, 2019 · Synced Jul 23, 2026, 2:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Short-Term Evaluation of Corneal Staining With Balafilcon A Lenses and Two Multi-Purpose Solutions

NCT01240122
View directory record Official record
Conditions
Corneal Staining
Interventions
Biotrue MPS, Investigational MPS
Device
Lead sponsor
Abbott Medical Optics
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Santa Ana, California
Source: ClinicalTrials.gov public record
Updated Mar 2, 2025 · Synced Jul 23, 2026, 2:11 AM EDT
Completed Not applicable Interventional Results available

Lens Wearing Experience and Biocompatibility of a Marketed Multi-Purpose Disinfecting Solution in Silicone Hydrogel and Soft Contact Lens Wearers

NCT01484938
View directory record Official record
Conditions
Refractive Error
Interventions
OPTI-FREE PureMoist
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Oct 9, 2012 · Synced Jul 23, 2026, 2:11 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Skin Imaging to Inform Laser Treatments

NCT04336163
View directory record Official record
Conditions
Port-Wine Stain, Rosacea, Telangiectasia, Angioma
Interventions
Optical Coherence Tomography
Device
Lead sponsor
University of California, Irvine
Other
Eligibility
4 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Jan 29, 2024 · Synced Jul 23, 2026, 2:11 AM EDT
Terminated Phase 3 Interventional

DY002: Safety and Effectiveness of DYME as an Agent for Selective Staining of the Anterior Capsule During Cataract Surgery

NCT00596492
View directory record Official record
Conditions
Mature Cataracts
Interventions
DYME
Drug
Lead sponsor
Aqumen Biopharmaceuticals, N.A.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
9
States / cities
Inglewood, California • Miami, Florida • Des Peres, Missouri + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 1, 2009 · Synced Jul 23, 2026, 2:11 AM EDT
Completed Phase 4 Interventional

Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Cataract Surgery

NCT05626478
View directory record Official record
Conditions
Corneal Edema, Corneal Defect, Anterior Chamber Inflammation, Ocular Pain, Corneal Staining, Visual Outcome, CME - Cystoid Macular Edema
Interventions
Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate 1% Oph Susp, Prolensa 0.07% Ophthalmic Solution
Drug
Lead sponsor
Nicole Fram M.D.
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Jul 23, 2026, 2:11 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Study of the Presence and Extent of Corneal Disturbance Associated With B+L Biotrue MPS Used With B+L PureVision Lenses

NCT01268306
View directory record Official record
Conditions
Keratitis
Interventions
B+L Biotrue MPS and B+L PureVision
Device
Lead sponsor
Epstein, Arthur B., OD, FAAO
Individual
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 21, 2016 · Synced Jul 23, 2026, 2:11 AM EDT
Completed Not applicable Interventional

Port Wine Stains Treatment Matrix RF Study

NCT01101360
View directory record Official record
Conditions
Port Wine Stains
Interventions
Matrix RF, Matrix RF followed by Pulse Dye Laser, Pulse Dye Laser followed by Matrix RF
Device
Lead sponsor
Syneron Medical
Industry
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 1, 2014 · Synced Jul 23, 2026, 2:11 AM EDT
Withdrawn No phase listed Observational

Optical Frequency Domain Imaging (OFDI) in Dermatology

NCT01438047
View directory record Official record
Conditions
Port Wine Stain
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 3, 2014 · Synced Jul 23, 2026, 2:11 AM EDT
Completed No phase listed Observational

Indigo Carmine Staining and Narrow Band Imaging (NBI) of Colonic Mucosa for Detection of Dysplasia in Ulcerative Colitis

NCT00961948
View directory record Official record
Conditions
Ulcerative Colitis
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 26, 2013 · Synced Jul 23, 2026, 2:11 AM EDT
Completed Phase 2 Interventional

Prolongation of Contact Lens Comfortable Wear Duration by CLM2 Topical Gel

NCT03994406
View directory record Official record
Conditions
Contact Lens Discomfort, Contact Lens-induced Corneal Disorder, Contact Lens Acute Red Eye, Contact Lens-induced Corneal Fluorescein Staining
Interventions
CLM2 topical gel, Placebo topical gel
Drug
Lead sponsor
Glia, LLC
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Mar 23, 2023 · Synced Jul 23, 2026, 2:11 AM EDT
Active, not recruiting No phase listed Observational

Multicenter Phenotype-Genotype Analysis of Vascular Stains to Optimize Treatment Utilizing Optical Coherence Tomography

NCT04772911
View directory record Official record
Conditions
Vascular Stains
Interventions
Optical Coherence Tomography (OCT)
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
Not listed
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
2
States / cities
Irvine, California • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jul 23, 2026, 2:11 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Topical Cyclosporine and Disease Progression

NCT00567983
View directory record Official record
Conditions
Disease Progression, Disease Severity, Staining, Schirmers, OSDI
Interventions
Restasis, Endura
Drug
Lead sponsor
Innovative Medical
Industry
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 24, 2008 · Synced Jul 23, 2026, 2:11 AM EDT