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Showing 1–24 of 43 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Sternotomy Clear all
Withdrawn Phase 4 Interventional

ABC Blocks for Cardiac Surgery

NCT05589363
View directory record Official record
Conditions
Pain
Interventions
ABC block with bupivacaine/liposomal bupivacaine, ABC block with saline
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 26, 2025 · Synced Jun 26, 2026, 4:06 PM EDT
Terminated Phase 3 Interventional

D-PLEX 302: Efficacy and Safety of D-PLEX in the Prevention of Sternal Infection Post Cardiac Surgery

NCT03558984
View directory record Official record
Conditions
Surgical Site Infection, Sternal Infection, Cardiac Surgery
Interventions
D-PLEX, Standard of Care
Drug · Other
Lead sponsor
PolyPid Ltd.
Industry
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Rochester, Minnesota • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 14, 2022 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Not applicable Interventional

A Comparison of Post-Sternotomy Dressings

NCT02198066
View directory record Official record
Conditions
Impaired Wound Healing, Postoperative Wound Infection-deep
Interventions
Dry Sterile Dressing, Metallic Silver Dressing, Ionic Silver Dressing
Other
Lead sponsor
Carilion Clinic
Other
Eligibility
21 Years and older
Enrollment
351 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 22, 2014 · Synced Jun 26, 2026, 4:06 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Clinical Outcomes in Patients Treated With SternaLock Blu

NCT03709693
View directory record Official record
Conditions
Cardiac Surgical Procedures, Coronary Artery Disease, Heart Valve Diseases
Interventions
SternaLock Blu
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 100 Years
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
4
States / cities
Indianapolis, Indiana • Kansas City, Missouri • Memphis, Tennessee + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2021 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Phase 1 Interventional

A Comparison Of The 3M TM S Surgical Skin Closure System To The Standard Vicryl Suture Closure of Sternotomy Incisions During Cardiac Surgery

NCT00576745
View directory record Official record
Conditions
Wound Infection
Interventions
Vicryl Suture, 3M TM S Surgical Skin Closure System
Procedure · Device
Lead sponsor
American Heart Association
Other
Eligibility
18 Years to 90 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 17, 2012 · Synced Jun 26, 2026, 4:06 PM EDT
Completed No phase listed Observational

Implantation of the HeartMate 3 in Subjects With Heart Failure Using Surgical SWIFT HM3 PMS

NCT04548128
View directory record Official record
Conditions
Advanced Refractory Left Ventricular Heart Failure
Interventions
HeartMate 3 Left Ventricular Assist System (HM3 LVAS)
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
31
States / cities
Little Rock, Arkansas • Palo Alto, California • Aurora, Colorado + 26 more
Source: ClinicalTrials.gov public record
Updated Jan 31, 2023 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Phase 3 Interventional Results available

Pecto-Intercostal Fascial Block for Postoperative Analgesia After Cardiac Surgery

NCT03482973
View directory record Official record
Conditions
Coronary Artery Disease, Sternal Pain
Interventions
Bupivacaine Group, Placebo
Drug · Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 2, 2020 · Synced Jun 26, 2026, 4:06 PM EDT
Recruiting Phase 2Phase 3 Interventional

Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children

NCT04724252
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Gabapentin, Placebo
Drug · Other
Lead sponsor
University of California, Davis
Other
Eligibility
Up to 17 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Jun 26, 2026, 4:06 PM EDT
Not listed Phase 1 Interventional

Liposomal Bupivacaine vs Bupivacaine for Pain Control After Sternotomy

NCT04585867
View directory record Official record
Conditions
Pain Management, Sternotomy
Interventions
Exparel, Bupivacaine
Drug
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 13, 2020 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Not applicable Interventional

Regional Anesthesia for Cardiothoracic Enhanced Recovery (RACER) Study

NCT03611374
View directory record Official record
Conditions
Congenital Heart Defect, Congenital Heart Disease, Anesthesia, Local, Opioid Use
Interventions
Bilateral Erector Spinae Plane Block (ESPB)
Procedure
Lead sponsor
Stanford University
Other
Eligibility
0 Years to 99 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Phase 3 Interventional

Safety and Hemostatic Efficacy of Fibrin Sealant Vapor Heated, Solvent/Detergent Treated (FS VH S/D) Compared With Currently Licensed TISSEEL VH Fibrin Sealant in Subjects Undergoing Cardiac Surgery

NCT00161733
View directory record Official record
Conditions
Cardiac Surgery Requiring Cardiopulmonary Bypass and Median Sternotomy, Cardiopulmonary Bypass, Sternotomy
Interventions
Fibrin Sealant Vapor Heated Solvent/Detergent Treated (FS VH S/D), TISSEEL VH fibrin sealant
Drug
Lead sponsor
Baxter Healthcare Corporation
Industry
Eligibility
18 Years and older
Timeline
2002 – 2004
U.S. locations
22
States / cities
Phoenix, Arizona • Orange, California • Gainesville, Florida + 19 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Jun 26, 2026, 4:06 PM EDT
Enrolling by invitation No phase listed Observational

Enhanced Sternal Closure With Montage or Montage-CT to Evaluate Post-Operative Opioid Use Following Median Sternotomy

NCT07215546
View directory record Official record
Conditions
Retrospective Review, Cerclage, Pain Management
Interventions
Montage or Montage CT
Device
Lead sponsor
Abyrx, Inc.
Industry
Eligibility
19 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Naples, Florida • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Not applicable Interventional Results available

An Evaluation of Rigid Sternal Fixation in Supporting Bone Healing and Improving Postoperative Recovery

NCT01783483
View directory record Official record
Conditions
Coronary Artery Disease, Angina Pectoris, Cardiac Valve Disease
Interventions
SternaLock Blue closure system, Suture Wire
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
12
States / cities
Jacksonville, Florida • Orlando, Florida • Atlanta, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Sep 7, 2017 · Synced Jun 26, 2026, 4:06 PM EDT
Not listed Not applicable Interventional

Regional Anesthesia for Cardiothoracic Enhanced Recovery

NCT03781440
View directory record Official record
Conditions
Opioid Use, Anesthesia, Local, Cardiac Disease, Pain, Acute
Interventions
Bilateral ESP catheter with lidocaine, Bilateral ESP catheter with saline
Procedure
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Sep 21, 2023 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Primary Plating in Sternotomy Patients for Osteosynthesis and Pain

NCT00819286
View directory record Official record
Conditions
Sternal Wound Infection, Sternal Non-union, Pain, Mediastinitis
Interventions
SternaLock Rigid Fixation Plates, wire (control)
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
5
States / cities
Phoenix, Arizona • Sacramento, California • Chicago, Illinois + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 12, 2018 · Synced Jun 26, 2026, 4:06 PM EDT
Active, not recruiting Not applicable Interventional

The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial

NCT03447938
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
MICS CABG, Conventional CABG
Procedure
Lead sponsor
Ottawa Heart Institute Research Corporation
Other
Eligibility
18 Years and older
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • La Crosse, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Jun 26, 2026, 4:06 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Postop Pain in the MICS Patients Versus Sternotomy Patients

NCT04003584
View directory record Official record
Conditions
Pain, Postoperative, Surgery
Interventions
Coronary bypass surgery
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
Not listed
Enrollment
179 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 27, 2023 · Synced Jun 26, 2026, 4:06 PM EDT
Terminated Phase 2Phase 3 Interventional

A Phase II/III Study of Continuous Local Anesthetic Infusion in Median Sternotomy Following Cardiac Surgery

NCT00586976
View directory record Official record
Conditions
Cardiac Surgery
Interventions
Ropivacaine, Normal saline
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Jun 26, 2026, 4:06 PM EDT
Not listed Phase 1 Interventional

Study to Evaluate the Safety and Efficacy of Dermal Injections of JVS-100 Given to Adults Receiving Median Sternotomy

NCT01657045
View directory record Official record
Conditions
Median Sternotomy
Interventions
JVS-100 or placebo
Biological
Lead sponsor
SironRX Therapeutics, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
6
States / cities
Tampa, Florida • Chicago, Illinois • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2013 · Synced Jun 26, 2026, 4:06 PM EDT
Completed No phase listed Observational Results available

TEE 3D RV Assessment for SAVR, Mini AVR, and TAVR

NCT05804240
View directory record Official record
Conditions
Right Ventricular Dysfunction
Interventions
3D TEE RVEF
Diagnostic Test
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Jun 26, 2026, 4:06 PM EDT
Terminated Phase 1 Interventional

Liposomal Bupivacaine Pharmacokinetic Study After Median Sternotomy Incision Infiltration in a Pediatric Cardiac Surgery

NCT04685421
View directory record Official record
Conditions
Cardiac Conditions
Interventions
Bupivacaine liposome
Drug
Lead sponsor
Nicklaus Children's Hospital f/k/a Miami Children's Hospital
Other
Eligibility
2 Years to 17 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 4, 2023 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Phase 4 Interventional Results available

PAIN - Postoperative Analgesia INvestigation

NCT02111746
View directory record Official record
Conditions
Postoperative Pain
Interventions
Exparel, Bupivacaine hydrochloride, Patient Controlled Analgesia (PCA)
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Jun 26, 2026, 4:06 PM EDT
Active, not recruiting Early Phase 1 Interventional

ESP/PIF for Sternotomy

NCT04985500
View directory record Official record
Conditions
Cardiac Surgery, Sternotomy
Interventions
ESP block, PIF block, Ultrasound, Bupivacain
Procedure · Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 85 Years
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Jun 26, 2026, 4:06 PM EDT
Withdrawn Not applicable Interventional

Pectoral Nerves Block to Relieve Post-sternotomy Pain After Cardiac Surgery

NCT04282239
View directory record Official record
Conditions
Pain, Postoperative, Cardiac Surgery
Interventions
PECS2 block, Ropivacaine 0.5% Injectable Solution, Lidocaine Epinephrine, Dexmedetomidine 0.004 MG/ML
Procedure · Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
19 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Mineola, New York
Source: ClinicalTrials.gov public record
Updated Dec 28, 2021 · Synced Jun 26, 2026, 4:06 PM EDT