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ClinicalTrials.gov public records Last synced Oct 8, 2026, 2:47 PM EDT

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Showing 97–120 of 156 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Stiffness, Arterial Clear all
Completed Phase 2 Interventional Results available

Study of the Safety and Efficacy of LCZ696 on Arterial Stiffness in Elderly Patients With Hypertension

NCT01692301
View directory record Official record
Conditions
Hypertension
Interventions
LCZ696, Olmesartan, LCZ696 matching placebo, Olmesartan matching placebo, amlodipine, hydrochlorothiazide
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
60 Years and older
Enrollment
454 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
11
States / cities
Clearwater, Florida • Chicago, Illinois • Baltimore, Maryland + 8 more
Source: ClinicalTrials.gov public record
Updated May 4, 2016 · Synced Oct 8, 2026, 2:47 PM EDT
Completed No phase listed Observational

CADASIL Disease Discovery

NCT02821780
View directory record Official record
Conditions
Germline Mutation in the NOTCH 3 Gene, Cardiovascular Disease, Arterial Stiffness, Pathogenesis of CADASIL, Clinical Phenotype of CADASIL
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
18 Years to 100 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
2
States / cities
Bethesda, Maryland • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 8, 2026, 2:47 PM EDT
Not listed Not applicable Interventional

Vitamin K to Slow Progression of Cardiovascular Disease Risk in Hemodialysis Patients

NCT03311321
View directory record Official record
Conditions
Cardiovascular Diseases, Chronic Kidney Disease Stage 3, Chronic Kidney Disease Stage 4, Chronic Kidney Disease Stage 5, Vitamin K Deficiency, Hemodialysis
Interventions
Vitamin K2 (menaquinone-7; 360-mcg/d), Placebo-Control
Dietary Supplement
Lead sponsor
Augusta University
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2019 · Synced Oct 8, 2026, 2:47 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Research Study for Children About Heart Changes and Obstructive Sleep Apnea (OSA)

NCT01837459
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Not listed
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
5 Years to 13 Years
Enrollment
231 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2015
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 14, 2016 · Synced Oct 8, 2026, 2:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Vascular and Metabolic Consequences of Adopting a Westernized Lifestyle

NCT03785470
View directory record Official record
Conditions
Vascular Diseases
Interventions
Fructose and physical inactivity
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 45 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 17, 2022 · Synced Oct 8, 2026, 2:47 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Vitamin D and Arterial Stiffness in Elderly

NCT03649802
View directory record Official record
Conditions
Vitamin D Deficiency, Arterial Stiffness
Interventions
Low dose vitamin D3, High dose vitamin D3
Dietary Supplement
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
65 Years to 89 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Mar 21, 2022 · Synced Oct 8, 2026, 2:47 PM EDT
Terminated Phase 4 Interventional Results available

Effect of the Direct Renin Inhibitor Aliskiren on Endothelial Function and Arterial Stiffness in Diabetic Subjects

NCT01349114
View directory record Official record
Conditions
Diabetes, Pre-hypertension, Hypertension
Interventions
aliskiren 300 mg once daily, Placebo/sugar pill
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 80 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 11, 2017 · Synced Oct 8, 2026, 2:47 PM EDT
Completed Early Phase 1 Interventional Results available

Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients

NCT04620382
View directory record Official record
Conditions
Neurogenic Orthostatic Hypotension, Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy, Parkinson Disease
Interventions
Midodrine, Placebo pill, Abdominal compression, sham compression
Drug · Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
40 Years to 80 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 8, 2026, 2:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dose-dependent Effects of Second-hand Smoke on Vascular Function

NCT01007760
View directory record Official record
Conditions
Cardiovascular Disease
Interventions
Respirable suspended particles (RSP) PM 2.5 dose of second-hand smoke
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 40 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 19, 2011 · Synced Oct 8, 2026, 2:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Low-intensity Resistance Exercise and Diet on Arterial Function and Blood Pressure

NCT01371370
View directory record Official record
Conditions
Obesity, Pre-hypertension, Hypertension
Interventions
Resistance exercise training, Hypocaloric diet, Resistance exercise training & diet
Other
Lead sponsor
Florida State University
Other
Eligibility
40 Years to 65 Years · Female only
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Aug 5, 2014 · Synced Oct 8, 2026, 2:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Influence of Cardiorespiratory Fitness and Body Composition on Resting and Post-exercise Indices of Vascular Health in Young Adults

NCT06163456
View directory record Official record
Conditions
Endothelial Dysfunction, Arterial Stiffness
Interventions
Acute submaximal exercise
Other
Lead sponsor
Towson University
Other
Eligibility
18 Years to 29 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Towson, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 8, 2023 · Synced Oct 8, 2026, 2:47 PM EDT
Completed Phase 2 Interventional Results available

Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid

NCT03648996
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, Hyperuricemia
Interventions
Low-fructose diet, isocaloric, Allopurinol, Placebo, Low-fructose, hypocaloric
Other · Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
40 Years to 75 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 3, 2023 · Synced Oct 8, 2026, 2:47 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Vitamin D, Insulin Sensitivity, and Vascular Associations in Adolescents

NCT01041365
View directory record Official record
Conditions
Insulin Sensitivity, Flow-mediated Dilation, Arterial Stiffness
Interventions
Not listed
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
14 Years to 18 Years · Female only
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 14, 2014 · Synced Oct 8, 2026, 2:47 PM EDT
Recruiting Phase 1Phase 2 Interventional

HEART: Pilot Randomized Controlled Trial

NCT07483177
View directory record Official record
Conditions
Thoracic Aortic Aneurysm
Interventions
Spironolactone, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 8, 2026, 2:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Coconut Sugar Lowers Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults

NCT05645991
View directory record Official record
Conditions
Aging, Blood Pressure, Arterial Stiffness
Interventions
Coconut Sap Powder (CSP), Placebo
Dietary Supplement
Lead sponsor
Ball State University
Other
Eligibility
40 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Muncie, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 12, 2022 · Synced Oct 8, 2026, 2:47 PM EDT
Active, not recruiting Phase 2 Interventional

Nicotinamide Riboside Supplementation for Treating Arterial Stiffness and Elevated Systolic Blood Pressure in Patients With Moderate to Severe CKD

NCT04040959
View directory record Official record
Conditions
Vascular Diseases, Kidney Disease, Blood Pressure, Oxidative Stress
Interventions
Nicotinamide riboside
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
35 Years to 80 Years
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 8, 2026, 2:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessing Impacts of Static Magnetic Fields on Peripheral Pulses and Skin Blood Flow

NCT04539704
View directory record Official record
Conditions
Arterial Stiffness, Magnetic Field Exposure, Peripheral Arterial Disease
Interventions
magnet and sham
Device
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years to 35 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Davie, Florida
Source: ClinicalTrials.gov public record
Updated Jun 10, 2025 · Synced Oct 8, 2026, 2:47 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Effects of Age and Exercise on Blood Pressure Regulation

NCT00319397
View directory record Official record
Conditions
Cardiovascular Disease, Aging
Interventions
Exercise-Training Program
Behavioral
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
55 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 14, 2009 · Synced Oct 8, 2026, 2:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Bikram Yoga on Arterial Stiffness and Endothelial Function in Middle-Aged Adults

NCT02488148
View directory record Official record
Conditions
Aging
Interventions
Hot yoga, Non-heated yoga
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
40 Years to 60 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 12, 2018 · Synced Oct 8, 2026, 2:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women

NCT02122198
View directory record Official record
Conditions
Cognitive Impairment, Executive Dysfunction, Endothelial Dysfunction, Cardiovascular Disease
Interventions
Leuprolide acetate, Estradiol, Medroxyprogesterone, Placebo
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
40 Years to 60 Years · Female only
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
2
States / cities
Aurora, Colorado • Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced Oct 8, 2026, 2:47 PM EDT
Recruiting Not applicable Interventional

Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes

NCT06735651
View directory record Official record
Conditions
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female, Adult, Endothelial Function (Reactive Hyperemia), Arterial Stiffness, Cognition, Oxidative Stress, Gut Microbiota, Overweight, Inflammation, Microvascular Function, Body Composition
Interventions
Wild Blueberry, Placebo
Dietary Supplement
Lead sponsor
Georgia State University
Other
Eligibility
20 Years to 65 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 8, 2026, 2:47 PM EDT
Completed Not applicable Interventional

Strive Cardio for Endometrial Cancer Survivors

NCT06534008
View directory record Official record
Conditions
Endometrial Cancer, Cardiovascular Diseases
Interventions
12-week home-based exercise intervention
Behavioral
Lead sponsor
Jess S. Gorzelitz
Other
Eligibility
18 Years and older · Female only
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Oct 8, 2026, 2:47 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Sympathetic Regulation of Large Artery Stiffness in Humans With ISH

NCT04423627
View directory record Official record
Conditions
Hypertension, Systolic, Stiffness, Aortic
Interventions
Clonidine, Hydrochlorothiazide, Placebo
Drug
Lead sponsor
University of Iowa
Other
Eligibility
60 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
2
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 8, 2025 · Synced Oct 8, 2026, 2:47 PM EDT
Active, not recruiting Phase 2 Interventional

Causal Mechanisms in Adolescent Arterial Stiffness

NCT04128969
View directory record Official record
Conditions
Lipid Disorder, Dyslipidemias, Aortic Stiffness, Insulin Resistance Syndrome, Metabolic Syndrome, Pediatric Obesity
Interventions
CS-
Dietary Supplement
Lead sponsor
Baylor College of Medicine
Other
Eligibility
11 Years to 21 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 10, 2025 · Synced Oct 8, 2026, 2:47 PM EDT