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ClinicalTrials.gov public records Last synced Oct 21, 2026, 2:37 AM EDT

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Showing 265–288 of 1,715 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Stress Disorders, Post-Traumatic Clear all
Recruiting Not applicable Interventional

Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course

NCT06957067
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
CPT Skills, Cognitive Processing Therapy, Present Centered Therapy, Shared Decision Making, Measurement Based Care
Behavioral
Lead sponsor
United States Department of Defense
Federal
Eligibility
18 Years and older
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
Phoenix, Arizona • New Orleans, Louisiana • Charleston, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 21, 2026, 2:37 AM EDT
Completed Phase 1 Interventional

Improving Quality-of-life and Depressive Symptoms of Combat Veterans Via Internet-based Intervention

NCT01231711
View directory record Official record
Conditions
Depression, Post-Traumatic Stress Disorder, Functional Status
Interventions
Vets Prevail
Behavioral
Lead sponsor
Prevail Health Solutions, LLC
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 1, 2010 · Synced Oct 21, 2026, 2:37 AM EDT
Completed Not applicable Interventional

Cortisol Augmentation of Prolonged Exposure Therapy

NCT00751855
View directory record Official record
Conditions
PTSD
Interventions
Prolonged Exposure therapy, Hydrocortisone, placebo
Behavioral · Drug
Lead sponsor
VISN 3 Mental Illness Research, Education and Clinical Center
Federal
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 27, 2012 · Synced Oct 21, 2026, 2:37 AM EDT
Completed Not applicable Interventional

MGH Trauma-related Nightmares SDI Study

NCT05195684
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
imaginal probe
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 6, 2022 · Synced Oct 21, 2026, 2:37 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Geodon (Ziprasidone) for Posttraumatic Stress Disorder

NCT00208208
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Post-Traumatic Stress Disorder, PTSD
Interventions
Ziprasidone
Drug
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 64 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2005
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 15, 2006 · Synced Oct 21, 2026, 2:37 AM EDT
Completed Not applicable Interventional

McLean and Genomind Prospective Study

NCT03113890
View directory record Official record
Conditions
Major Depressive Disorder, PTSD
Interventions
Phlebotomy - Folate, Cheek Swab, Self-report surveys
Genetic · Other
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 23, 2021 · Synced Oct 21, 2026, 2:37 AM EDT
Recruiting Phase 2 Interventional

Safety and Efficacy of Cannabidiol (CBD) for Symptoms of PTSD in Adults

NCT05269459
View directory record Official record
Conditions
PTSD
Interventions
Cannabidiol Administered as Nantheia ATL5, Placebo
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
21 Years to 65 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2029
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 21, 2026, 2:37 AM EDT
Completed Not applicable Interventional Results available

Enhancing Equitable and Effective (E-3) Post Traumatic Stress Disorder (PTSD) Disability Assessment

NCT00699660
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
CAPS/WHODAS, Nonstructured Interview
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 99 Years
Enrollment
406 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
11
States / cities
North Little Rock, Arkansas • Palo Alto, California • West Haven, Connecticut + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 16, 2018 · Synced Oct 21, 2026, 2:37 AM EDT
Completed Phase 4 Interventional Results available

Dopamine Enhancement of Fear Extinction Learning in PTSD (1R21MH108753)

NCT02560389
View directory record Official record
Conditions
Stress Disorder, Post Traumatic
Interventions
Placebo, Levodopa
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
25 Years to 50 Years · Female only
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jun 25, 2019 · Synced Oct 21, 2026, 2:37 AM EDT
Completed Not applicable Interventional Results available

Brief Restructuring Intervention Following Trauma Exposure

NCT02808468
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Alcohol Use Disorders
Interventions
Brief Cognitive Therapy
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Oct 21, 2026, 2:37 AM EDT
Recruiting Not applicable Interventional

The New Empowerment After eXposure to Trauma (NEXT) Study

NCT07175025
View directory record Official record
Conditions
PTSD - Post Traumatic Stress Disorder, PTSD (Childbirth-Related)
Interventions
Narrative Exposure Therapy (NET)
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 21, 2026, 2:37 AM EDT
Recruiting Not applicable Interventional

Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms

NCT05414708
View directory record Official record
Conditions
PTSD, Military Activity, Post-Traumatic Headache, Posttraumatic Stress Disorder, Posttraumatic Stress Disorder, Delayed Onset, Sleep Disturbance, Nightmare, Irritable Mood, Anger, Combat and Operational Stress Reaction, Combat Stress Disorders, Military Family, Military Operations, Emotional Regulation, Emotion Processing
Interventions
Art Therapy
Behavioral
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Bethesda, Maryland • Fort Belvoir, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Oct 21, 2026, 2:37 AM EDT
Completed Not applicable Interventional Results available

Effect of tDCS Timing on Safety Memory in PTSD

NCT04152772
View directory record Official record
Conditions
PTSD
Interventions
transcranial direct current stimulation
Device
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Oct 21, 2026, 2:37 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Post Traumatic Stress Disorder (PTSD) Hyperarousal Symptoms Treated With Physiological Stress Management

NCT00855816
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Breathing training
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Oct 20, 2014 · Synced Oct 21, 2026, 2:37 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Ketamine Infusion Therapy for PTSD in Combat Veterans

NCT03088384
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Ketamine
Drug
Lead sponsor
Klarisana Physician Services PLLC
Industry
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Oct 2, 2018 · Synced Oct 21, 2026, 2:37 AM EDT
Recruiting Not applicable Interventional

Project COMET: Massed Prolonged Exposure for PTSD and SUD

NCT06968832
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Substance Use Disorders (SUD), Comorbidity, Trauma and Stressor Related Disorders
Interventions
Massed Prolonged Exposure Therapy (M-PE), Standard outpatient SUD care
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Oct 21, 2026, 2:37 AM EDT
Completed Not applicable Interventional

Prolonged Exposure for Post Traumatic Stress Disorder (PTSD) Among Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) Personnel

NCT01049516
View directory record Official record
Conditions
Posttraumatic Stress Disorders, Combat Disorders
Interventions
Prolonged Exposure Therapy - Massed, Prolonged Exposure Therapy - Spaced, Minimal Contact Control, Present-Centered Therapy
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
366 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2018
U.S. locations
3
States / cities
Philadelphia, Pennsylvania • Killeen, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Nov 27, 2018 · Synced Oct 21, 2026, 2:37 AM EDT
Recruiting Not applicable Interventional

Comparing Telehealth to In-person a Combined Metacognitive Training in Veterans With mTBI/PTSD

NCT05380050
View directory record Official record
Conditions
Brain Injury, Cognition, PTSD, Intervention
Interventions
Goal Management Training plus Attention Training, Brain Health Workshop and National Geographic Movies
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
30 Years to 55 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 21, 2026, 2:37 AM EDT
Completed No phase listed Observational

Relationship Between Postpartum Mood Disorders and Delivery Experience

NCT03004872
View directory record Official record
Conditions
Postpartum Period, Depression, Stress Disorders, Post-Traumatic
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older · Female only
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 12, 2019 · Synced Oct 21, 2026, 2:37 AM EDT
Terminated Phase 4 Interventional Results available

Antidepressant Response in Older Adults With Comorbid PTSD and MDD

NCT04697693
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Major Depressive Disorder
Interventions
Escitalopram, Duloxetine
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
60 Years to 105 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Oct 21, 2026, 2:37 AM EDT
Completed Not applicable Interventional Results available

Accelerated TMS to a Novel Brain Target in MDD and PTSD

NCT03114891
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Major Depressive Disorder
Interventions
Transcranial Magnetic Stimulation (TMS), Task, fMRI-guided TMS target
Device · Behavioral · Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 6, 2023 · Synced Oct 21, 2026, 2:37 AM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Xyrem for Treatment Refractory Insomnia Due to PTSD

NCT00330291
View directory record Official record
Conditions
PTSD, Anxiety, Post Traumatic
Interventions
Xyrem
Drug
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Sep 7, 2012 · Synced Oct 21, 2026, 2:37 AM EDT
Completed Not applicable Interventional Results available

Trauma-Sensitive Yoga for Female Veterans With PTSD Who Experienced Military Sexual Trauma

NCT02640690
View directory record Official record
Conditions
Stress Disorders, Post-traumatic
Interventions
Trauma Center Trauma Sensitive Yoga Intervention (TCTSY), Cognitive Processing Therapy
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older · Female only
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
2
States / cities
Decatur, Georgia • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 8, 2024 · Synced Oct 21, 2026, 2:37 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 3

NCT04916340
View directory record Official record
Conditions
Peripheral Vascular Diseases
Interventions
Muscular Strength Training Group, Muscular Fitness Training Group
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 35 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 21, 2026, 2:37 AM EDT