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Showing 1–24 of 36 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Stuttering Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Speech Signals in Stuttering

NCT05668923
View directory record Official record
Conditions
Stuttering, Childhood
Interventions
Speech sound stimulation
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
5 Years to 17 Years
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
2
States / cities
Ann Arbor, Michigan • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 6, 2026, 1:41 PM EDT
Recruiting Not applicable Interventional

Stuttering and Neuromodulation

NCT07222163
View directory record Official record
Conditions
Stuttering
Interventions
Soterix Medical 1x1 tDCS system, Speech therapy sessions
Device · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 6, 2026, 1:41 PM EDT
Completed Phase 2Phase 3 Interventional

A Study to Assess the Efficacy and Safety of Pagoclone for Adults With Stuttering

NCT00830154
View directory record Official record
Conditions
Stuttering
Interventions
pagoclone, placebo
Drug · Other
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years to 80 Years
Enrollment
321 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 27, 2012 · Synced Sep 6, 2026, 1:41 PM EDT
Completed Phase 2 Interventional

EXPRESS: Examining Pagoclone for Persistent Developmental Stuttering Study

NCT00216255
View directory record Official record
Conditions
Persistent Developmental Stuttering
Interventions
Pagoclone, Placebo
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
16
States / cities
Peoria, Arizona • Orange, California • Riverside, California + 13 more
Source: ClinicalTrials.gov public record
Updated Sep 2, 2012 · Synced Sep 6, 2026, 1:41 PM EDT
Recruiting Phase 2 Interventional

Lumateperone in the Treatment of Stuttering, Childhood Onset Fluency Disorder

NCT07734103
View directory record Official record
Conditions
Stuttering, Adult
Interventions
Lumateperone (ITI-007), Placebo Tablet or Capsule
Drug
Lead sponsor
CSTrials Inc.
Network
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Costa Mesa, California
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 6, 2026, 1:41 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Central Mechanisms in Speech Motor Control Studied With H215O PET

NCT00001308
View directory record Official record
Conditions
Communication Disorder, Healthy, Stuttering, Tourette Syndrome, Voice Disorder
Interventions
Not listed
Lead sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
Eligibility
18 Years to 85 Years
Enrollment
1,163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1992 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Sep 6, 2026, 1:41 PM EDT
Completed No phase listed Observational

Dopamine Function in Developmental Stuttering

NCT00024960
View directory record Official record
Conditions
Developmental Stuttering
Interventions
Not listed
Lead sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
Eligibility
18 Years to 55 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2010
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 6, 2026, 1:41 PM EDT
Completed Phase 2 Interventional

Effects of Ecopipam or Placebo in Adults With Stuttering (Speak Freely)

NCT04492956
View directory record Official record
Conditions
Childhood-Onset Fluency Disorder (Stuttering)
Interventions
Ecopipam, Placebo
Drug
Lead sponsor
Emalex Biosciences Inc.
Industry
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
9
States / cities
Riverside, California • Santa Ana, California • Jacksonville, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Sep 6, 2026, 1:41 PM EDT
Terminated Not applicable Interventional Results available

Non-invasive Brain Stimulation in Adults Who Stutter

NCT03437512
View directory record Official record
Conditions
Stuttering, Developmental
Interventions
Anodal tDCS, Fluency training, Sham tDCS
Device · Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 28, 2021 · Synced Sep 6, 2026, 1:41 PM EDT
Not listed Phase 2Phase 3 Interventional

Efficacy and Tolerability of Ecopipam in Adults With Childhood Onset Fluency Disorder (Stuttering).

NCT02909088
View directory record Official record
Conditions
Stuttering, Adult, Childhood-onset Fluency Disorder, Speech Disorders, Language Disorders, Communication Disorder
Interventions
Ecopipam 50mg, Ecopipam 100mg
Drug
Lead sponsor
Gerald Maguire, MD
Other
Eligibility
18 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
2
States / cities
Riverside, California
Source: ClinicalTrials.gov public record
Updated Oct 25, 2016 · Synced Sep 6, 2026, 1:41 PM EDT
Active, not recruiting Not applicable Interventional

Effects of Altered Auditory Feedback on Speech Fluency

NCT06011837
View directory record Official record
Conditions
Stuttering, Adult
Interventions
Altered Auditory Feedback
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
18 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 6, 2026, 1:41 PM EDT
Suspended Phase 3 Interventional Accepts healthy volunteers

A Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Tolerability of Asenapine With Flexible Dosing From 5mg to 20mg in Adults With Developmental Stuttering

NCT01684657
View directory record Official record
Conditions
Stuttering
Interventions
Asenapine
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 70 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated May 19, 2014 · Synced Sep 6, 2026, 1:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigating Speech Sequencing in Neurotypical Speakers and Persons With Disordered Speech

NCT05437159
View directory record Official record
Conditions
Stuttering, Developmental, Aphasia, Primary Progressive
Interventions
Learning of non-native phoneme combinations: 6 training sessions, Learning of non-native phoneme combinations: 1 training session, Learning of novel multisyllabic nonwords, Anodal tDCS, Sham tDCS, Learning of non-native phoneme combinations: 8 training sessions
Behavioral · Other
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
6 Years and older
Enrollment
278 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
3
States / cities
Boston, Massachusetts • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 6, 2026, 1:41 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Information Processing Biases in Adults Who Stutter

NCT06422442
View directory record Official record
Conditions
Stuttering, Adult
Interventions
Threat-related stimulus exposure
Behavioral
Lead sponsor
University of Memphis
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated May 20, 2024 · Synced Sep 6, 2026, 1:41 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Dopamine and Sensorimotor Function in Stuttering

NCT07215884
View directory record Official record
Conditions
Stuttering, Adult
Interventions
Aripiprazole 10 MG, Placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 6, 2026, 1:41 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Exploring the Nature, Assessment and Treatment of Stuttering

NCT05908123
View directory record Official record
Conditions
Stuttering, Stuttering, Adult, Stuttering, Childhood, Stuttering, Developmental
Interventions
The Blank Center CARE Model(TM) for Individuals who Stutter
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
2 Years to 85 Years
Enrollment
3,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2035
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Sep 6, 2026, 1:41 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Network Connectivity and Temporal Processing in Adolescents Who Stutter

NCT05286151
View directory record Official record
Conditions
Stuttering, Childhood, Stuttering
Interventions
Rhythm discrimination
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
9 Years to 13 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Sep 6, 2026, 1:41 PM EDT
Recruiting Not applicable Interventional

Using Non-invasive Brain Stimulation to Explore Potential Treatments to Reduce Speech Errors in Adults Who Stutter

NCT07354139
View directory record Official record
Conditions
Stuttering, Fluency Disorder
Interventions
High - Definition Transcranial Direct Current Stimulation
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
22 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 6, 2026, 1:41 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Auditory Prediction and Error Evaluation in the Speech of Individuals Who Stutter

NCT06181149
View directory record Official record
Conditions
Healthy Subjects, Stuttering, Developmental
Interventions
Delaying speech initiation, Auditory errors and pre-speech auditory modulation, Contributions of the speech premotor cortex to pre-speech auditory modulation, Delaying auditory feedback
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
3 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
2
States / cities
Tempe, Arizona • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 20, 2025 · Synced Sep 6, 2026, 1:41 PM EDT
Completed No phase listed Observational

Genetic Linkage Studies of Stuttering

NCT00001604
View directory record Official record
Conditions
Stuttering
Interventions
Not listed
Lead sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
Eligibility
6 Years and older
Enrollment
3,044 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 17, 2024 · Synced Sep 6, 2026, 1:41 PM EDT
Recruiting Not applicable Interventional

Organization and Development of Motor Cortical Circuits for Speech Production in Stuttering

NCT07180628
View directory record Official record
Conditions
Stutter, Stuttering, Adult, Stuttering, Stuttering, Developmental
Interventions
Speech Production During functional magnetic resonance imaging (MRI)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Sep 6, 2026, 1:41 PM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

The Effects of Tactile Speech Feedback on Stuttering Frequency

NCT01315730
View directory record Official record
Conditions
Stuttering
Interventions
Tactile Stimulation
Device
Lead sponsor
University of Mississippi, Oxford
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2011
U.S. locations
1
States / cities
University, Mississippi
Source: ClinicalTrials.gov public record
Updated May 11, 2014 · Synced Sep 6, 2026, 1:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Speech Processing in Stuttering

NCT04929184
View directory record Official record
Conditions
Stuttering, Stuttering, Childhood, Stuttering, Adult
Interventions
Speech and non-speech tasks
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
6 Years to 65 Years
Enrollment
145 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
2
States / cities
Ann Arbor, Michigan • East Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 6, 2026, 1:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Characteristics of Idiopathic Familial Speech Disorders

NCT00001551
View directory record Official record
Conditions
Developmental Articulation Disorder, Speech Disorder, Stuttering
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
375 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 1996
U.S. locations
2
States / cities
College Park, Maryland • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 6, 2026, 1:41 PM EDT