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Showing 1–21 of 21 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Submental Laxity Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Safety and Effectiveness Evaluation of the High-intensity Focused Ultrasound Device for Lifting Lax Submental and Neck Tissue

NCT07229430
View directory record Official record
Conditions
Skin Laxity (Submental and Neck), Facial Skin Laxity, Submental Tissue Laxity
Interventions
ULTRAFORMER MPT PLUS, Ulthera System
Device
Lead sponsor
CLASSYS Inc.
Industry
Eligibility
30 Years to 65 Years
Enrollment
273 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
5
States / cities
Los Angeles, California • Charlotte, North Carolina • Wilmington, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 19, 2026 · Synced Sep 6, 2026, 4:54 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Evaluation of the Ulthera® System for Treatment of the Face and Neck

NCT01713907
View directory record Official record
Conditions
Wrinkles, Rhytids, Skin Laxity
Interventions
Ulthera® Treatment
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
30 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 23, 2017 · Synced Sep 6, 2026, 4:54 PM EDT
Completed Not applicable Interventional Results available

Open-label, Prospective Evaluation of the Ulthera® System for Lifting Submental (Under the Chin) and Neck Tissue in Chinese Patients

NCT03351335
View directory record Official record
Conditions
Mild to Moderate Skin Laxity Under the Chin, Mild to Moderate Skin Laxity on Neck
Interventions
Microfocused ultrasound with visualization
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
35 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
7
States / cities
Los Gatos, California • San Diego, California • Vista, California + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Sep 6, 2026, 4:54 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Treatment to Lift Facial Lax Skin and Improve Facial Wrinkles Using Precise and Lift Applicators

NCT06333067
View directory record Official record
Conditions
Lax Skin
Interventions
Sofwave
Device
Lead sponsor
Sofwave Medical LTD
Industry
Eligibility
35 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
2
States / cities
La Mesa, California • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 12, 2025 · Synced Sep 6, 2026, 4:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

SofWave Treatment to Lift Lax Tissue in the Submental and Neck Zones and to Lift the Eyebrow

NCT04969380
View directory record Official record
Conditions
Skin Laxity
Interventions
Sofwave
Device
Lead sponsor
Sofwave Medical LTD
Industry
Eligibility
35 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 6, 2026, 4:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Assessment of Skin Tightening and Contour Change of Submental Tissue Using Bipolar Radiofrequency Microneedling

NCT04477187
View directory record Official record
Conditions
Skin Laxity
Interventions
Dermal Handpiece
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Sep 6, 2026, 4:54 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of SofWave Sofware-Guided Energy Delivery for Lower Face and Neck Rejuvenation

NCT07723664
View directory record Official record
Conditions
Facial Wrinkles, Jawline Contour, Skin Laxity
Interventions
SofWave
Device
Lead sponsor
Sofwave Medical LTD
Industry
Eligibility
40 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 6, 2026, 4:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treatment With the Evoke System for Facial and Submental Laxity

NCT04719013
View directory record Official record
Conditions
Laxity; Skin
Interventions
Evoke radiofrequency device
Device
Lead sponsor
InMode MD Ltd.
Industry
Eligibility
35 Years to 75 Years
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
5
States / cities
Sacramento, California • Greenwood Village, Colorado • New Orleans, Louisiana + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 30, 2023 · Synced Sep 6, 2026, 4:54 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy of a 2,910 nm Fractional Ablative Fiber Laser (UltraClear®) for Improvements of Skin Laxity and Lifting of the Lower Face, Submental, and Neck Treatment Areas

NCT07759817
View directory record Official record
Conditions
Skin Laxity (Submental and Neck), Skin Lifting and Tightening
Interventions
2910 nm fiber laser (UltraClear®)
Device
Lead sponsor
FA Corporation
Industry
Eligibility
35 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
2
States / cities
Prospect, Kentucky • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 6, 2026, 4:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Lifting and Tightening of the Face in Subjects With Skin of Darker Color

NCT01368965
View directory record Official record
Conditions
Facial Skin Laxity
Interventions
Ulthera® System treatment
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
30 Years to 65 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
2
States / cities
Chevy Chase, Maryland • Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 12, 2017 · Synced Sep 6, 2026, 4:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Safety and Effectiveness Evaluation of the Device in Achieving Submental Lift

NCT02832674
View directory record Official record
Conditions
Skin Laxity
Interventions
Percutaneous Radiofrequency single treatment
Device
Lead sponsor
ThermiGen, LLC
Industry
Eligibility
35 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Montclair, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Sep 6, 2026, 4:54 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Treatment With the Profound System for Submental Laxity

NCT02595216
View directory record Official record
Conditions
Submental Laxity
Interventions
Profound System
Device
Lead sponsor
Syneron Medical
Industry
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
5
States / cities
San Mateo, California • San Ramon, California • Alpharetta, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 5, 2017 · Synced Sep 6, 2026, 4:54 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Safety and Efficacy of SofWave Treatment to Lift Lax Tissue in the Submental and Neck Zones and to Lift the Eyebrow

NCT04146584
View directory record Official record
Conditions
Skin Laxity, Wrinkle, Brow Lifting
Interventions
Sofwave Treatments
Device
Lead sponsor
Sofwave Medical LTD
Industry
Eligibility
35 Years to 80 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
5
States / cities
Sacramento, California • New York, New York • Charlotte, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 21, 2021 · Synced Sep 6, 2026, 4:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

CONFORM: Rotational Fractional Resection for Submental Contouring

NCT03407313
View directory record Official record
Conditions
Skin Laxity, Lipodystrophy
Interventions
Rotational fractional resection (1.5mm diameter device)
Device
Lead sponsor
Recros Medica, Inc.
Industry
Eligibility
30 Years and older
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
6
States / cities
Campbell, California • Newport Beach, California • Roseville, California + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 2, 2021 · Synced Sep 6, 2026, 4:54 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The INFORM Study: Rotational Fractional Resection for Submental Contouring

NCT03853980
View directory record Official record
Conditions
Skin Laxity
Interventions
Focal Contouring System
Device
Lead sponsor
Recros Medica, Inc.
Industry
Eligibility
30 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
14
States / cities
Campbell, California • Encino, California • Los Angeles, California + 11 more
Source: ClinicalTrials.gov public record
Updated Mar 5, 2020 · Synced Sep 6, 2026, 4:54 PM EDT
Active, not recruiting Not applicable Interventional

Safety and Efficacy of 2910 nm Fiber Laser Resurfacing and Laser-Coring

NCT07254884
View directory record Official record
Conditions
Rhytids, Skin Laxity
Interventions
2,910 nm mid-infrared erbium-doped fluoride fiber glass laser (UltraClear, Acclaro Medical)
Device
Lead sponsor
FA Corporation
Industry
Eligibility
45 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Edina, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 6, 2026, 4:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The PREFORM Study: Rotational Fractional Resection for Submental Contouring

NCT03966924
View directory record Official record
Conditions
Skin Laxity, Lipodystrophy
Interventions
Rotational fractional resection (1.5mm Diameter Device)
Device
Lead sponsor
Recros Medica, Inc.
Industry
Eligibility
30 Years and older
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Newport Beach, California
Source: ClinicalTrials.gov public record
Updated May 10, 2021 · Synced Sep 6, 2026, 4:54 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Bipolar RF Microneedling for Improved Laxity and Lift of the Submental and Neck Tissue and Effect on Elastin

NCT04245696
View directory record Official record
Conditions
Skin Laxity
Interventions
Dermal Handpiece / SubQ Handpiece
Device
Lead sponsor
Candela Corporation
Industry
Eligibility
21 Years to 70 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Marlborough, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 5, 2021 · Synced Sep 6, 2026, 4:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy Evaluation of the Xerf Device for Aesthetic Treatments

NCT07585591
View directory record Official record
Conditions
Facial Aging, Facial Skin Laxity, Submental and Neck Skin Laxity
Interventions
Noninvasive dual-frequency monopolar radiofrequency
Device
Lead sponsor
CynosureLutronic
Industry
Eligibility
22 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
4
States / cities
Naperville, Illinois • Hunt Valley, Maryland • Montclair, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 6, 2026, 4:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Bausch Health Thermage FXL for Use on Lower Face and Submentum Area

NCT04606368
View directory record Official record
Conditions
Skin Wrinkling
Interventions
Thermage FLX
Device
Lead sponsor
Lorraine Hickson
Other
Eligibility
40 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Sep 6, 2026, 4:54 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy of Matrix Pro for Eyebrow Lift and Lift of Submental/Neck Laxity

NCT06640998
View directory record Official record
Conditions
Laxity; Skin
Interventions
Matrix Pro
Device
Lead sponsor
Candela Corporation
Industry
Eligibility
18 Years to 75 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Marlborough, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Sep 6, 2026, 4:54 PM EDT