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Showing 1–24 of 1,350 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Substance Abuse Disorder Clear all
Completed Phase 2 Interventional Results available

Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving

NCT01822587
View directory record Official record
Conditions
Cocaine Addiction
Interventions
Propranolol, 40 mg, Propranolol, 80 mg, Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
181 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 25, 2019 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Multiple Ascending Dose Study of Safety and Pharmacokinetics of NP10679 in Normal Healthy Volunteers

NCT04007263
View directory record Official record
Conditions
Stroke, Ischemic, Pain, Postoperative, Substance Abuse, Subarachnoid Hemorrhage
Interventions
Placebo, NP10679
Drug
Lead sponsor
Neurop Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 3, 2019 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Phase 1 Interventional

Use of a Mobile Health Sensor in an Open Label Trial of Lorcaserin for the Treatment of Cannabis Use Disorder

NCT02932215
View directory record Official record
Conditions
Cannabis Use Disorder
Interventions
lorcaserin, Fitbit Charge HR
Drug · Other
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 10, 2019 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Not applicable Interventional

Targeting PM to Improve HIV Adherence in Adolescents at Risk for Substance Abuse

NCT01959217
View directory record Official record
Conditions
Adherence, Substance Abuse
Interventions
PM Component Text Reminders
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
16 Years to 29 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
2
States / cities
La Jolla, California • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 9, 2018 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Phase 4 Interventional Results available

Efficacy Study of Quetiapine Plus Topiramate for Reducing Cannabis Consumption and Bipolar Mania

NCT00393978
View directory record Official record
Conditions
Bipolar Disorder, Cannabis-Related Disorder
Interventions
Quetiapine and placebo, Quetiapine and Topiramate
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
12 Years to 21 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2014
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 25, 2017 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

SARA - Substance Abuse Research Assistant

NCT03255317
View directory record Official record
Conditions
Substance Use
Interventions
Reinforcers, Notifications
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 24 Years
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 17, 2018 · Synced Sep 3, 2026, 3:10 PM EDT
Completed No phase listed Observational

PCORnet Opioid Surveillance Study

NCT03743493
View directory record Official record
Conditions
Opioid Use, Opioid Abuse
Interventions
Not listed
Lead sponsor
Louisiana Public Health Institute
Other
Eligibility
Not listed
Enrollment
15,438,284 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
24
States / cities
Irvine, California • La Jolla, California • Los Angeles, California + 15 more
Source: ClinicalTrials.gov public record
Updated Nov 11, 2020 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Not applicable Interventional

Optimizing Outcomes Using Suboxone for Opiate Dependence

NCT00591617
View directory record Official record
Conditions
Opioid Dependency
Interventions
Psychosocial treatment plus Suboxone pharmacotherapy
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
15 Years and older
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 28, 2013 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Not applicable Interventional Results available

Computer-based Intervention for Alcohol-using HIV/HCV+ Women

NCT03362476
View directory record Official record
Conditions
Human Immunodeficiency Virus, Hepatitis C, Alcohol Abuse
Interventions
Computer-based alcohol reduction intervention, Brief clinician-delivered MET, Standard of care
Behavioral
Lead sponsor
New York University
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adaptation Processes in School-Based Substance Abuse Programs

NCT01755533
View directory record Official record
Conditions
Substance Use
Interventions
Rural curriculum, Classic curriculum
Other
Lead sponsor
Penn State University
Other
Eligibility
11 Years to 15 Years
Enrollment
2,827 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 19, 2017 · Synced Sep 3, 2026, 3:10 PM EDT
Completed No phase listed Observational

The Effect of Fetal Gender on Maternal Substance Abuse Treatment

NCT00882648
View directory record Official record
Conditions
Drug Dependence, Pregnancy
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
Female only
Enrollment
850 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 20, 2013 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Not applicable Interventional Results available

Telephone Coaching of Family Members of Veterans With Substance Abuse Problems

NCT03246646
View directory record Official record
Conditions
Substance Abuse
Interventions
Coaching
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 29, 2021 · Synced Sep 3, 2026, 3:10 PM EDT
Not listed Not applicable Interventional

A Mobile Intervention for Black Individuals Who Engage in Hazardous Drinking

NCT06416059
View directory record Official record
Conditions
Alcohol Abuse, Anxiety
Interventions
Mobile Application
Behavioral
Lead sponsor
University of Houston
Other
Eligibility
21 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 16, 2024 · Synced Sep 3, 2026, 3:10 PM EDT
Completed No phase listed Observational Results available

Maintaining Independence and Sobriety Through Systems Integration, Outreach, and Networking

NCT02942979
View directory record Official record
Conditions
Co-Occurring Disorders, Homelessness, Substance Abuse Disorder, Mental Illness
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 20, 2023 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Phase 2 Interventional

Validating Interventions for Diverse Adolescents

NCT01018654
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
Standard Cognitive Behavioral Treatment, Culturally Adapted Cognitive-Behavioral Treatment
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
13 Years to 18 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 17, 2023 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Not applicable Interventional

A Feasibility Study of Smoking Cessation Program in Radiation Oncology

NCT00236288
View directory record Official record
Conditions
Cancer and Tobacco Abuse
Interventions
Bupropion and intensive behavioral therapy
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 30, 2007 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Not applicable Interventional Results available

Effect of Theta Burst Stimulation on Alcohol Cue Reactivity

NCT04223154
View directory record Official record
Conditions
Alcohol Drinking, Alcohol Use Disorder, Trauma Injury, Alcohol Dependence, Alcohol Abuse
Interventions
Real iTBS to the dlPFC, Sham iTBS to the dlPFC
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Not applicable Interventional

Recovery Housing and Drug Abuse Treatment Outcome

NCT03278496
View directory record Official record
Conditions
Mental and Behavioral Disorders Due to Use of Cocaine: Harmful Use, Opiate Addiction
Interventions
Recovery Housing plus Counseling, Usual Care Referral, Recovery Housing Only
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 55 Years
Enrollment
243 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2008
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 10, 2017 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Not applicable Interventional Results available

Women Veterans' Substance Abuse Treatment

NCT00734903
View directory record Official record
Conditions
Substance Use Disorders
Interventions
A Woman's Path to Recovery, 12-Step Facilitation
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years · Female only
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
2
States / cities
Bedford, Massachusetts • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 4, 2018 · Synced Sep 3, 2026, 3:10 PM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers

N-acetylcysteine Effects on Tetrahydrocannabinol

NCT02335060
View directory record Official record
Conditions
Healthy
Interventions
Delta-9-THC, N-acetylcysteine, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 30, 2022 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Computerized Brief Intervention vs. Delayed Computerized Brief Intervention

NCT01936623
View directory record Official record
Conditions
Drug Abuse
Interventions
Computerized Brief Intervention
Behavioral
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Edgewood, New Mexico
Source: ClinicalTrials.gov public record
Updated Jul 20, 2017 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Phase 2 Interventional

Clinical Trial of Abstinence-Linked Money Management

NCT00536900
View directory record Official record
Conditions
Substance Abuse
Interventions
Advisor-Teller Money Manager, FIT
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 29, 2020 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Phase 1 Interventional

Brief Interventions for Drop-out Re-engagement

NCT00350571
View directory record Official record
Conditions
Substance Abuse
Interventions
brief (behavioral therapy), Drop out re-engagement motivational intervention, standard care follow up
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
299 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 16, 2014 · Synced Sep 3, 2026, 3:10 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Pharmacokinetic and Pharmacodynamic Effects of Oral Cannabidiol (CBD) Under Acute and Chronic Exposure Conditions

NCT04283019
View directory record Official record
Conditions
Cannabis, Drug Effects
Interventions
CBD, THC
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 55 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Sep 3, 2026, 3:10 PM EDT