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ClinicalTrials.gov public records Last synced Nov 7, 2026, 8:14 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 265–288 of 505 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Abuse Problem Clear all

Conditions: Substance-Related Disorders
Interventions: Cognitive Remediation; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: Not listed
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Parenting Capacities of Substance Abusing Mothers
Interventions: Mothers and Toddlers Program, Parent Education; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 45 Years · Female only
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2015
U.S. locations: 2
States / cities: New Haven, Connecticut • West Haven, Connecticut

Conditions: Post-traumatic Stress Disorder, Alcohol Abuse, Alcohol Dependence
Interventions: Adolescent Trauma Support Program; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 12 Years to 18 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Substance Abuse
Interventions: Meetings with implementation leader(s), the SAAS survey, Patient surveys; Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 113,123 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 2
States / cities: Boston, Massachusetts • New York, New York

Conditions: Substance Use Disorders
Interventions: incentives; Behavioral
Lead sponsor: Brandeis University; Other
Eligibility: 18 Years and older
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Bedford, Massachusetts

Conditions: Stroke, Ischemic, Pain, Postoperative, Substance Abuse, Subarachnoid Hemorrhage
Interventions: Placebo, NP10679; Drug
Lead sponsor: Neurop Inc.; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Mood Disorders, Substance-Related Disorders
Interventions: Facilitate evidence-based treatment for depression; Procedure
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: Not listed
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 5
States / cities: No. Little Rock, Arkansas • New Orleans, Louisiana • Biloxi, Mississippi + 2 more

Conditions: Methamphetamine-dependence, Substance Abuse
Interventions: Ibudilast 20mg, Ibudilast 50mg, Placebo oral tablet; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 55 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Torrance, California

Conditions: Intravenous Drug Abuse, HIV Infections
Interventions: Skin and Needle Hygiene Intervention, No intervention - assessment-only condition; Behavioral · Other
Lead sponsor: University of Northern Colorado; Other
Eligibility: 18 Years and older
Enrollment: 87 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Substance-Related Disorders
Interventions: Brief intervention using motivational interviewing; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 868 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Crime, Substance Abuse, HIV Risk, Criminogenic Thinking, Shame
Interventions: Impact of Crime group intervention; Behavioral
Lead sponsor: George Mason University; Other
Eligibility: 18 Years and older · Male only
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2016
U.S. locations: 1
States / cities: Fairfax, Virginia

Conditions: Obesity, Substance Abuse, Violence, Mental Health
Interventions: Not listed
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 11 Years to 15 Years
Enrollment: 12,651 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Adolescent Drinking, Adolescent Problem Behavior
Interventions: Qlarity app users; Behavioral
Lead sponsor: Oregon Research Behavioral Intervention Strategies, Inc.; Industry
Eligibility: 13 Years to 18 Years
Enrollment: 257 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Springfield, Oregon

Conditions: Substance-Related Disorders
Interventions: Functional Family Therapy, Motivational Enhancement Tx/Cognitive Behavioral Tx, Contingency Management; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 13 Years to 17 Years
Enrollment: 212 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Alcohol Abuse, Substance Abuse, Post Traumatic Stress Disorder
Interventions: self-guided mHealth app only, self-guided mHealth app + 'real-time' feedback; Behavioral
Lead sponsor: UConn Health; Other
Eligibility: 18 Years to 29 Years · Male only
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Substance Abuse
Interventions: Placebo, Cabergoline; Drug
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 55 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011
U.S. locations: 1
States / cities: Houston, Texas

Conditions: ADHD, Attention Deficit Hyperactivity Disorder
Interventions: Methylphenidate, Atomoxetine; Drug
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 7 Years to 12 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: New York, New York

Conditions: Disability
Interventions: Benefits Counseling, VA Orientation; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: HIV/AIDS, HIV Infections, Substance Use, Substance Abuse, Substance Use Disorders, Sexually Transmitted Diseases
Interventions: Link2CARE; Behavioral
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 80 Years
Enrollment: 307 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: HIV, Intravenous Substance Abuse, Women's Health, Organization and Administration, Primary Prevention, Implementation Science
Interventions: Practice Facilitation; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older · Female only
Enrollment: 130 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cocaine, Substance Abuse, Infant, Newborn, Pregnancy, Pregnant Women, Prenatal Care
Interventions: Not listed
Lead sponsor: NICHD Neonatal Research Network; Network
Eligibility: Not listed
Enrollment: 11,811 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1993 – 2011
U.S. locations: 5
States / cities: Miami, Florida • Detroit, Michigan • Durham, North Carolina + 2 more

Conditions: HIV/AIDS
Interventions: Theater/Pilot Testing; Other
Lead sponsor: Yale University; Other
Eligibility: 13 Years to 18 Years · Female only
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Paterson, New Jersey

Conditions: Substance Dependence, Compliance, Treatment Outcome
Interventions: Contracting, Prompting and Reinforcing; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: Not listed
Enrollment: 157 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Ends 2005
U.S. locations: 1
States / cities: Salem, Virginia

Conditions: Hepatitis C, Substance Abuse
Interventions: Family-Responsive Psychoeducation Program (PERF); Behavioral
Lead sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA); NIH
Eligibility: 18 Years and older
Enrollment: 556 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: St Louis, Missouri

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Cognitive Remediation in Early Substance Abuse Treatment

Trial of Mentalization-Based Therapy for Substance Using Mothers of Infants and Toddlers

Adolescent Trauma Recovery and Stress Disorders Collaborative Care (ATRSCC) Model Program Trial

A Phased-Implementation Feasibility and Proof-of-Concept Study to Assess Incorporating the NIDA CTN Common Data Elements (CDEs) Into the Electronic Health Record (EHR) in Large Primary Care Settings ("CDE-EHR-PC" Study), Phase 3

Enhancing Early-Phase Care for Primary Care Patients With Unhealthy Substance Use

A Multiple Ascending Dose Study of Safety and Pharmacokinetics of NP10679 in Normal Healthy Volunteers

Facilitating the Adoption of Evidence-Based Depression Management in Substance Use Treatment Programs

Safety Interaction Trial Ibudilast and Methamphetamine

Reducing Health Problems Associated With Injection Drug Use

Brief Intervention in Primary Care for Problem Drug Use and Abuse

Trial of Impact of Crime Group Intervention for Jail Inmates

Health Behaviors in School-age Children: 2009-2010

Mindfulness Mobile App to Reduce Adolescent Substance Use

Family and Adolescent Motivational Incentives for Leveraging Youth

Project BrEAtHe: A Culturally Tailored MBSR Intervention for Young Adult Black Men

A Pilot Study of Cabergoline for the Treatment of Cocaine Dependence

Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk

Preserving Function Among Disability Applicants

Health and Justice: A Continuum of Care for HIV and SU for Justice-Involved Young Adults (PHASE 2)

Implementing PrEP for Women Who Inject Drugs

The Maternal Lifestyle Study (MLS)

The Dreamer Girls Project: Adaptation of SISTA/SIHLE for HIV/AIDS and Substance Abuse Prevention Among Black Adolescent Girls

Improving Substance Abuse Treatment Aftercare Adherence and Outcome

Psychoeducation for Hepatitis and Alcohol Behaviors