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ClinicalTrials.gov public records Last synced Nov 7, 2026, 8:28 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 289–312 of 505 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Abuse Problem Clear all

Conditions: Substance-related Disorders, Drug Addiction, Human Immunodeficiency Virus, AIDS, HIV Infections
Interventions: Physician Management, Counseling; Other · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2012
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Substance Abuse, Depression, Anxiety Disorder
Interventions: Mindfulness Based Relapse Prevention (MBRP), Twelve-Step Facilitation Intervention (TSF); Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 204 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 2
States / cities: Tuscaloosa, Alabama • Charleston, South Carolina

Conditions: Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
Interventions: Buprenorphine; Drug
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 55 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2000 – 2004
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Treatment Resistant Depression, Substance Use Disorders
Interventions: Psilocybin; Drug
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2031
U.S. locations: 2
States / cities: Indianapolis, Indiana

Conditions: Substance Abuse, Delinquency, Mental Health
Interventions: Contingency Management-Family Engagement, Treatment as Usual; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 12 Years to 17 Years
Enrollment: 101 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Florence, South Carolina

Conditions: HIV Infections, Substance Abuse
Interventions: Decision aid, Standard care; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 164 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: HIV Infections
Interventions: Not listed
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Hepatitis C, Substance Use Disorders, Substance Abuse, Intravenous
Interventions: elbasvir-grazoprevir (50 mg/100 mg); Drug
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 2
States / cities: Portland, Oregon

Conditions: Substance Abuse
Interventions: Contingency management; Behavioral
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years and older
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2006
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Major Depression, Anxiety Disorder, Post-Traumatic Stress Disorder, Substance Abuse Disorder
Interventions: Photobiomodulation with a super-luminous light emitting diode; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 60 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Substance Abuse
Interventions: CBT, Cognitive Behavioral Therapy, FFT, Family Functional Therapy; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 13 Years to 18 Years
Enrollment: 140 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Substance Abuse
Interventions: Strengthening Families Program Online eLearning Game, SFP Home-use DVD, Wait-Listed Control; Behavioral
Lead sponsor: Strengthening Families Program LLC; Industry
Eligibility: 11 Years and older
Enrollment: 480 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Cocaine-Related Disorders, Opioid-Related Disorders, Heroin Dependence, Substance Abuse, Intravenous
Interventions: Abstinence & Work, Work Only; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 117 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2004
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Schizophrenia, Psychotic Disorders, Substance Abuse, Alcohol Abuse
Interventions: Risperidone Long Acting, oral risperidone; Drug
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 95 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2010
U.S. locations: 8
States / cities: Miami, Florida • Kansas City, Missouri • St Louis, Missouri + 5 more

Conditions: HIV Infections
Interventions: Peer HIV Education Program; Behavioral
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 18 Years and older
Enrollment: 2,610 participants
Healthy volunteers: Accepts healthy volunteers
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania

Conditions: Substance-Related Disorders
Interventions: Substance Abuse Education, Mind-body Bridging; Behavioral
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 55 Years · Female only
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 2
States / cities: Salt Lake City, Utah

Conditions: Substance Abuse Problem
Interventions: Counselor Training Methods; Other
Lead sponsor: Sheidow Consulting, Inc.; Other
Eligibility: 22 Years and older
Enrollment: 97 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Stimulant Use, Human Immunodeficiency Virus (HIV), Depression
Interventions: ARTEMIS, Contingency management for Antiretroviral (ARV) adherence; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 59 Years
Enrollment: 189 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Posttraumatic Stress Disorder, Substance Abuse
Interventions: Cognitive behavioral treatment enhanced by virtual reality; Other
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance Abuse
Interventions: Contingency management; Behavioral
Lead sponsor: UConn Health; Other
Eligibility: 18 Years and older
Enrollment: 172 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2007
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Male Reproductive Problem
Interventions: Cannabis plant (THC 20mg), Cannabis (0%/ THC / 0% CBD), Cannabis plant (THC 40mg); Drug
Lead sponsor: Kanako Hayashi; Other
Eligibility: 21 Years to 64 Years · Male only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Pullman, Washington

Conditions: Substance Abuse, Offenders, Criminal Thinking, HIV Risk Behaviors
Interventions: Cognitive Behavioral Therapy; Behavioral
Lead sponsor: George Mason University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 251 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Substance-Related Disorders, Mental Health
Interventions: SET-R/Healthy Home; Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 173 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Assault by Handgun Discharge, Violence, Homicide, Sexual Assault by Bodily Force, Substance Abuse Problem
Interventions: Lithium Water, placebo: spring mineral water, natural spring water; Dietary Supplement · Other
Lead sponsor: American Society Of Thermalism And Climatology Inc; Other
Eligibility: 14 Years to 60 Years
Enrollment: 400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Newark, New Jersey

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Buprenorphine and Integrated HIV Care

Mindfulness-Based Recovery in Veterans

Counseling Conditions for Buprenorphine in a Primary Care Clinic - 1

Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder

Testing a Promising Treatment for Youth Substance Abuse in a Community Setting

OPTIONS: A Patient-Centered HIV Prevention Decision Aid for PrEP Uptake for Women With Substance Use in Treatment Settings

Evaluation of an HIV Outreach Program

Hepatitis C Treatment in PWIDs: MAT or Syringe Exchange Assisted-therapy vs Standard of Care

Vouchers vs. Prizes for Methadone Patients - 1

Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depression

Adolescent Substance Abuse: Progressive Treatment

Strengthening Families Program Online

The Therapeutic Workplace Initiation Study

Risperidone Long-acting Versus Oral Risperidone in Patients With Schizophrenia and Alcohol Use Disorder

A Study of Peer Education to Prevent HIV Transmission Among Injection Drug Users and Their HIV Risk Contacts

Behavioral Treatment for Substance Abuse

Web-Based Contingency Management Training for Addictions

Project neuroARTEMIS

Cognitive Behavioral Treatment of Posttraumatic Stress Disorder Enhanced by Virtual Reality for Individuals With PTSD and Substance Abuse

Lower-Cost Contingency Management in a Group Setting - 1

The Effects of Cannabis on Male Reproductive Functions

Effects of Manualized Treatment in a Seamless System

SET-Recovery/Healthy Home

Lithium Water in Gun Violence Prevention