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ClinicalTrials.gov public records Last synced Nov 7, 2026, 8:40 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 313–336 of 505 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Abuse Problem Clear all

Conditions: Mental and Behavioral Disorders Due to Use of Cocaine: Harmful Use, Opiate Addiction
Interventions: Recovery Housing plus Counseling, Usual Care Referral, Recovery Housing Only; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 243 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2008
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Substance-Related Disorders
Interventions: Functional Family Tx, Services as Usual; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 13 Years to 18 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Substance Abuse
Interventions: CBT4CBT program; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Drug Use, Substance Abuse, Mental Illness
Interventions: Integrated Harm Reduction Intervention (IHRI); Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 3
States / cities: New Haven, Connecticut • New York, New York • Orangeburg, New York

Conditions: Opioid Dependence
Interventions: Not listed
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 877 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2016
U.S. locations: 8
States / cities: Los Angeles, California • Sacramento, California • San Francisco, California + 5 more

Conditions: Substance Use, Delinquency, Risk for HIV Infection
Interventions: Multidimensional Family Therapy Cross-Systems, Enhanced Services as Usual; Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 13 Years to 17 Years
Enrollment: 154 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2011
U.S. locations: 5
States / cities: Clearwater, Florida • Largo, Florida • Miami, Florida

Conditions: Substance Abuse, Mental Health
Interventions: Positive Behavior Supports in Middle Schools; Behavioral
Lead sponsor: University of Oregon; Other
Eligibility: 11 Years to 15 Years
Enrollment: 13,498 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2015
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Nonsuicidal Self Injury, Alcohol Abuse, Vagus Nerve Stimulation
Interventions: Non-invasive Transcutaneous Nerve Stimulation (tVNS), No Intervention; Device
Lead sponsor: University of Notre Dame; Other
Eligibility: 13 Years to 17 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: South Bend, Indiana

Conditions: Substance Abuse Problem
Interventions: keepin' it REAL classic, keepin' it REAL rural, control; Behavioral
Lead sponsor: Penn State University; Other
Eligibility: 11 Years to 15 Years
Enrollment: 2,827 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2015
U.S. locations: 2
States / cities: Columbus, Ohio • University Park, Pennsylvania

Conditions: Obesity, Substance Abuse
Interventions: Yappalli; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older · Female only
Enrollment: 174 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2022
U.S. locations: 1
States / cities: McAlester, Oklahoma

Conditions: Substance Use Disorders
Interventions: Intensive referral to 12-step self-help groups; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years and older
Enrollment: 345 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Substance Use Disorder, Posttraumatic Stress Disorder
Interventions: Prolonged Exposure with Contingency Management, Standard Care; Behavioral
Lead sponsor: UConn Health; Other
Eligibility: 18 Years to 25 Years
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 3
States / cities: Farmington, Connecticut • Hartford, Connecticut • New Britain, Connecticut

Conditions: Homelessness, Substance Abuse Disorders, Mental Disorders
Interventions: Intensive Addiction/Housing Case Management, Housing Support Group; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 181 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Substance Abuse
Interventions: Not listed
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 14 Years to 17 Years
Enrollment: 514 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Mental Health
Interventions: Educational intervention; Other
Lead sponsor: Brooke Army Medical Center; Federal
Eligibility: Not listed
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Fort Sam Houston, Texas

Conditions: Substance Use, Substance Abuse, Substance-Related Disorders
Interventions: Processing of clinical notes in the EHR data collected during routine care; Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 89 Years
Enrollment: 64,996 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Cocaine Addiction, Cocaine Abuse, Cocaine Dependence, Substance Abuse
Interventions: Pramipexole, Placebo; Drug
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 55 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Substance Use Disorders, Substance Abuse
Interventions: Senyo App, Follow-up; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 2
States / cities: Scottsdale, Arizona • Rochester, Minnesota

Conditions: Substance Abuse, Substance Use, Child Abuse, Neglect, Child
Interventions: Peer Recovery Support, Family Treatment Drug Court with Medications for Opioid Use Disorders (MOUD), Relational Skill Building based on the Nurturing Parenting Program (NPP); Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: Not listed
Enrollment: 117 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Substance Abuse, Domestic Violence
Interventions: Individual Therapy, Individual Drug Counseling manual; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older · Male only
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Substance Use
Interventions: Reinforcers, Notifications; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 14 Years to 24 Years
Enrollment: 74 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Opioid-Related Disorders, HIV Infections, AIDS
Interventions: Buprenorphine, Integrated HIV care and office-based opioid dependence treatment; Drug · Behavioral
Lead sponsor: The New York Academy of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 1,350 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 10
States / cities: Tucson, Arizona • Oakland, California • San Francisco, California + 7 more

Conditions: HIV, AIDS, Substance Abuse, Inpatient
Interventions: Patient Navigation (PN) Group, Patient Navigator Plus Contingency Management (PN+CM) Group; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 801 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2015
U.S. locations: 12
States / cities: Birmingham, Alabama • Torrance, California • Miami, Florida + 8 more

Conditions: Substance Use
Interventions: ATTC strategy, ISF strategy; Behavioral
Lead sponsor: RTI International; Other
Eligibility: 18 Years and older
Enrollment: 190 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 39
States / cities: Phoenix, Arizona • Claremont, California • Irvine, California + 32 more

Search by objective public record fields.

Recovery Housing and Drug Abuse Treatment Outcome

Family Therapy Via Video Teleconference for Substance-Abusing Rural Adolescents

Feasibility of Providing Computerized CBT in the Black Church

Harm Reduction Services

Starting Treatment With Agonist Replacement Therapies Follow-up Study

Juvenile Detention to Community Life

Implementing School Wide PBS in Middle Schools: The Foundation for Effective Prevention

Technology Enhanced Adolescent Mental Health (TEAM)

Adaptation Processes in School-based Substance Abuse Prevention

Yappalli - The Road to Choctaw Health

Substance Abuse Self-Help Group Referral: Outcomes and Services Use

Integrated Treatment for Posttraumatic Stress Disorder and Substance Abuse in Young Adults

Addiction Housing Case Management for Homeless Veterans

Validating Adolescent SBIRT Measures

Educational Intervention for Optimizing Adolescent Mental Health Screening and Treatment in Pediatric Residency

Data-driven Identification for Substance Misuse

Pramipexole as a Treatment for Cocaine Dependence

Senyo Health With Substance Use Disorder (SUD) in Primary Care

Enhancing Permanency in Children and Families

An Integrated Substance Abuse-Domestic Violence (SADV) Treatment Outcome Study

SARA - Substance Abuse Research Assistant

Buprenorphine and Integrated HIV Care Evaluation

Hospital Visit as Opportunity for Prevention and Engagement for HIV-Infected Drug Users

Substance Abuse Treatment to HIV Care (SAT2HIV): The Implementation & Sustainment Facilitation Experiment