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ClinicalTrials.gov public records Last synced Nov 7, 2026, 8:59 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 361–384 of 505 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Abuse Problem Clear all

Conditions: Depression Disorders, ADHD, Substance Abuse, Social Stigma, Help-Seeking Behavior, Caregiver Burden
Interventions: Brief video; Other
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 25 Years to 50 Years
Enrollment: 1,600 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance Abuse, HIV Infections
Interventions: Stonewall Project; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older · Male only
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Substance Abuse
Interventions: contingency management; Behavioral
Lead sponsor: UConn Health; Other
Eligibility: 18 Years and older
Enrollment: 360 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Substance Use Disorders, Treatment Refusal
Interventions: Group Community Reinforcement Training for Parents, Individual Community Reinforcement Training for Parents; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: Not listed
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Opioid Related Disorders, Pregnancy, Opioid Dependence
Interventions: Methadone, Buprenorphine; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 41 Years · Female only
Enrollment: 175 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2010
U.S. locations: 6
States / cities: Baltimore, Maryland • Detroit, Michigan • Philadelphia, Pennsylvania + 3 more

Conditions: HIV Infections
Interventions: Clinic-based Delivery, Remote Delivery, Multi-modal Delivery; Behavioral
Lead sponsor: Florida State University; Other
Eligibility: 15 Years to 24 Years · Male only
Enrollment: 83 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 3
States / cities: Miami, Florida • Detroit, Michigan • Philadelphia, Pennsylvania

Conditions: Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse, Drug Abuse, Neonatal Abstinence Syndrome, Neonatal Opiate Withdrawal Syndrome, Drug Abuse in Pregnancy
Interventions: Buprenorphine Injection, Buprenorphine Sublingual Product; Drug
Lead sponsor: T. John Winhusen, PhD; Other
Eligibility: Not listed
Enrollment: 71 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 10
States / cities: Jacksonville, Florida • Boston, Massachusetts • Portland, Oregon + 6 more

Conditions: Substance Abuse, Decision Making, Shared, Implementation Science, Decision Making, Organizations, Substance-related Disorders, Policy
Interventions: Co-Design Sessions (CDS), Data products; Other
Lead sponsor: Chestnut Health Systems; Other
Eligibility: 18 Years and older
Enrollment: 341 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder, Substance Abuse, Alcohol Abuse
Interventions: Clozapine versus typical (conventional) and atypical antipsychotic medications; Drug
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 19 Years to 65 Years
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2004
U.S. locations: 1
States / cities: Jamaica Plain, Massachusetts

Conditions: Substance Use Disorders, Substance Abuse, Substance Use
Interventions: tDCS, tDCS Sham; Device
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years to 79 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Substance Abuse
Interventions: Personalized feedback report, Personalized feedback report plus education; Behavioral
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years to 105 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: HIV, Sexual Risk, Sexually Transmitted Diseases, Substance Abuse, Violence, Victimization
Interventions: Young Women's CoOp, Staying Healthy and Eating Well; Behavioral
Lead sponsor: RTI International; Other
Eligibility: 16 Years to 19 Years · Female only
Enrollment: 237 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 2
States / cities: Durham, North Carolina • Research Triangle Park, North Carolina

Conditions: Substance Abuse Problem, Alcohol Abuse, Alcohol Dependence
Interventions: SHIFT Cognitive Behavioral Therapy; Behavioral
Lead sponsor: Michael E. DeBakey VA Medical Center; Federal
Eligibility: 18 Years to 64 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Alcohol Abuse, Tobacco Dependence, Substance Abuse
Interventions: cSBI-M; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 18 Years to 25 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Computer-assisted, Evidence-based Psychosocial Intervention, for Substance Abuse Treatment
Interventions: Therapeutic Education System (TES), Standard Care; Behavioral
Lead sponsor: National Development and Research Institutes, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 376 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 10
States / cities: Cañon City, Colorado • Denver, Colorado • Model, Colorado + 5 more

Conditions: Substance Abuse
Interventions: Blood draw; Procedure
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years and older
Enrollment: 8,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1992 – 2006
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Medication Adherence, Substance Abuse, Intravenous, Risk Behavior, Hepatitis A, Hepatitis B, Hepatitis C
Interventions: Hepatitis A & B vaccine, Outreach, AIC, SEP; Biological · Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 14 Years to 29 Years
Enrollment: 546 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: San Francisco, California

Conditions: ADHD, Substance Abuse
Interventions: Methylphenidate (OROS-MPH), Methylphenidate (OROS-MPH) - Placebo; Drug
Lead sponsor: University of Cincinnati; Other
Eligibility: 13 Years to 18 Years
Enrollment: 303 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 12
States / cities: Denver, Colorado • Jacksonville, Florida • St. Petersburg, Florida + 9 more

Conditions: Substance Abuse, Trauma, Post Traumatic Stress Disorder, Integrated Treatment, Incarcerated Women
Interventions: Helping Women Recover/Beyond Trauma; Behavioral
Lead sponsor: University of Tulsa; Other
Eligibility: 18 Years and older · Female only
Enrollment: 95 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Taft, Oklahoma

Conditions: Substance Use Disorder (SUD)
Interventions: Not listed
Lead sponsor: Evidation Health; Industry
Eligibility: 21 Years and older
Enrollment: 1,910 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: San Mateo, California

Conditions: Alcohol Abuse, Cocaine Abuse, Marijuana Abuse
Interventions: MI-CBT, Brief Advice; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 16 Years to 45 Years · Female only
Enrollment: 168 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2010
U.S. locations: 2
States / cities: Bridgeport, Connecticut • New Haven, Connecticut

Conditions: Substance Abuse, Juvenile Delinquency, Sexual Behavior, Criminal Behavior, Violence, Depression, Anxiety, Suicide, Sexually Transmitted Infection, Educational Attainment
Interventions: Communities That Care; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 10 Years and older
Enrollment: 52,323 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2025
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Well-Being (Psychological Flourishing), Internalizing Mental Health Symptoms, Substance Abuse
Interventions: Mindfulness and Identity-Based Micropractice, Control Condition Micropractice; Behavioral
Lead sponsor: Cornell University; Other
Eligibility: 16 Years to 26 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance Use
Interventions: Motivational Interviewing; Behavioral
Lead sponsor: RTI International; Other
Eligibility: 18 Years to 99 Years
Enrollment: 827 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 39
States / cities: Phoenix, Arizona • Claremont, California • Irvine, California + 32 more

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Brief Intervention Addressing Stigma Among Parents of Children With Mental Health Problems

Stonewall Treatment Evaluation Project

A SMART Design for Attendance-based Prize CM

Individual vs. Group Community Reinforcement Training to Help Parents of Substance-using Treatment-refusing Youth

RCT Comparing Methadone and Buprenorphine in Pregnant Women

Young Men's Health Project Targeting HIV Risk Reduction and Substance Abuse

Medication Treatment for Opioid Use Disorder in Expectant Mothers: Infant Neurodevelopmental Outcomes Sub-study

Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention

Alcoholism and Schizophrenia: Effects of Clozapine

tDCS and Impulsivity

Impact of Personalized Feedback Alone on Substance Use Behaviors

Young Women's CoOp Study

Designing a Mobile App for Veterans With Substance Use Problems

cSBI-M for Young Military Personnel

CPT for Offenders With SUD

The Genetic Basis for Vulnerability to Substance Abuse

A Randomized Trial of Vaccine Adherence in Young Injection Drug Users

Attention Deficit Hyperactivity Disorder (ADHD) in Adolescents With Substance Use Disorders (SUD)

Substance Abuse and Trauma in Incarcerated Women

Research and Engagement on Substance Use: Harnessing Awareness and Personalized Education (RESHAPE) to Improve Well-being and Self-efficacy

Therapeutic Substance Abuse Treatment in Pregnancy - 1

The Community Youth Development Study: A Test of Communities That Care

Micropractices for Unhoused LGBTQ Youth

Substance Abuse Treatment to HIV Care (SAT2HIV): The Motivational Interviewing-based Brief Intervention Experiment