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ClinicalTrials.gov public records Last synced Nov 7, 2026, 9:08 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 385–408 of 505 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Abuse Problem Clear all

Conditions: Drug Abuse, Alcohol Abuse, Substance Abuse
Interventions: Random, no advanced notice drug and alcohol testing; Procedure
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 13 Years to 19 Years
Enrollment: 14,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1999 – 2002
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Cannabis Use, Cannabis Dependence, Cannabis Use Disorder, Cannabis Abuse, Cannabis Intoxication, Cannabis Smoking, Cannabis Withdrawal, Cannabis-Related Disorder, Cannabis Abuse, in Remission, Cannabis Abuse, Episodic Use, Marijuana, Marijuana Abuse, Marijuana Use, Marijuana Smoking, Marijuana Dependence, Marijuana User, Marijuana-Related Disorder, Marijuana Use Disorder, Addiction, Addiction, Substance, Substance Use, Substance Use Disorders, Substance Dependence, Substance Abuse, Substance Related Problem, Substance Abuse Drug Chronic
Interventions: Contingency Management, Elastic Net Regression; Behavioral · Device
Lead sponsor: Indiana University; Other
Eligibility: 14 Years to 17 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: HIV/AIDS, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Depression, Substance Use
Interventions: Counselor delivered telehealth intervention; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 29 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Substance Abuse
Interventions: Family Spirit curriculum; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 12 Years to 24 Years
Enrollment: 320 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2005
U.S. locations: 5
States / cities: Fort Defiance, Arizona • Tuba City, Arizona • Whiteriver, Arizona + 2 more

Conditions: Substance-Related Disorders
Interventions: Navigating my Journey program, Attention Control; Behavioral
Lead sponsor: Inflexxion, Inc.; Industry
Eligibility: 13 Years to 21 Years
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Newton, Massachusetts

Conditions: Substance Abuse, Families, Trauma
Interventions: Multidimensional Family Therapy, Group CBT; Other
Lead sponsor: University of Miami; Other
Eligibility: 13 Years to 17 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2010
U.S. locations: 2
States / cities: Miami, Florida • Luling, Louisiana

Conditions: Substance Use
Interventions: Mantente REAL; Behavioral
Lead sponsor: Arizona State University; Other
Eligibility: 10 Years to 17 Years
Enrollment: 5,524 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Substance Use
Interventions: iSBIRT; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 12 Years to 18 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Drug Overdose, Substance Abuse, Alcohol Abuse
Interventions: Observational EEG Monitoring; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Substance Abuse, HIV Infections
Interventions: Aripiprazole, Placebo; Drug
Lead sponsor: San Francisco Department of Public Health; Government
Eligibility: 18 Years to 60 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Substance Use Disorders
Interventions: Recovery Coach Intervention; Behavioral
Lead sponsor: Prisma Health-Upstate; Other
Eligibility: 18 Years to 60 Years
Enrollment: 99 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Greenville, South Carolina

Conditions: Substance Abuse
Interventions: Contingency management; Behavioral
Lead sponsor: UConn Health; Other
Eligibility: 18 Years and older
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2009
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Cocaine Use Disorders, HIV
Interventions: Active Cognitive Training (ACT), Control Training (CON); Device
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Substance Abuse, Bipolar Depression
Interventions: divalproex sodium ER, risperidone; Drug
Lead sponsor: Tuscaloosa Research & Education Advancement Corporation; Other
Eligibility: 19 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: Tuscaloosa, Alabama

Conditions: Substance Abuse Problem, Pregnancy
Interventions: Syntocinon treatment, Placebo; Drug · Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 42 Years · Female only
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2023
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Alcohol Abuse, Cannabis Abuse, Major Depressive Disorder, Substance-Related Disorders
Interventions: Integrated Cognitive Behavioral Therapy, Twelve Step Facilitation Therapy; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years to 70 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2004
U.S. locations: 1
States / cities: San Diego, California

Conditions: Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder, Alcohol Withdrawal, Alcohol Abuse, Alcohol Use Disorder, Cocaine Abuse, Cocaine Use Disorder, Cocaine Withdrawal, Benzodiazepine Abuse, Benzodiazepine Dependence, Substance Abuse, Heroin Overdoses, Heroin Withdrawal, Heroin Abuse
Interventions: Six Step Model of Self-Forgiveness, Treatment as Usual (TAU); Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: McKeesport, Pennsylvania

Conditions: Substance Abuse, Substance Dependence, Cognitive Impairment
Interventions: Cognitive Training + Work Therapy, Work Therapy; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Opioid Use Disorder, Infectious Disease, Risk Reduction Behavior, Substance Use, Substance Abuse, Stimulant Use Disorder
Interventions: Patient Navigator, Mobile Health Unit; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 601 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 3
States / cities: New Haven, Connecticut • Dallas, Texas • Fort Worth, Texas

Conditions: Co-Occurring Disorders, Homelessness, Substance Abuse Disorder, Mental Illness
Interventions: Not listed
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: Not listed
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Bedford, Massachusetts

Conditions: Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse, Drug Abuse, Neonatal Abstinence Syndrome, Neonatal Opioid Withdrawal Syndrome, Drug Abuse in Pregnancy
Interventions: Buprenorphine Injection, Buprenorphine Sublingual Product; Drug
Lead sponsor: T. John Winhusen, PhD; Other
Eligibility: 18 Years to 41 Years · Female only
Enrollment: 97 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 12
States / cities: Jacksonville, Florida • Boston, Massachusetts • Albuquerque, New Mexico + 8 more

Conditions: ADHD, Stimulant-Induced Euphoria
Interventions: SODAS MPH, Naltrexone; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 30 Years
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Dual Diagnosis
Interventions: Matching Symptom Severity to Service Intensity; Procedure
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: Not listed
Enrollment: 236 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Ends 2001
U.S. locations: 6
States / cities: Long Beach, California • Palo Alto, California • Gainesville, Florida + 3 more

Conditions: Substance-Related Disorders
Interventions: Behavior Therapy; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 99 Years
Enrollment: 561 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2004
U.S. locations: 6
States / cities: San Francisco, California • Tarzana, California • Norwalk, Connecticut + 2 more

Search by objective public record fields.

Student Athlete Testing Using Random Notification

Neuroimaging of Adolescent Cannabis Use Treatment

Youth to Text or Telehealth for Engagement in HIV Care

Family Spirit Study

Field Trial of a Relapse Prevention Program for Adolescents Receiving Substance Use Treatment

Family-Based Drug Services for Young Disaster Victims

'Keepin' It REAL in Mexico: An Adaptation and Multisite RCT Implementation of a Substance Abuse Prevention Curriculum for Adolescents in Three Mexico Cities.

Integration of (iSBIRT) for Teen Drug Use Into a Pediatric Network

EEG Monitoring in the Emergency Department

Aripiprazole Treatment for Methamphetamine Dependence Among High-risk Individuals

Barriers to Substance Use Disorder Recovery

Therapists to Administer Contingency Management-Therapist Phase - 1

Project IMPACT: Improving Memory Performance by Applying Cognitive Training

Divalproex ER vs. Risperidone for Bipolar Disorder With Comorbid Substance Use Disorder

Prenatal Cocaine, Nasal Oxytocin, and Maternal Psychophysiology

Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse

The Effect of Self-Forgiveness on Self-Stigma in Addiction.

Cognitive Remediation and Work Therapy in the Initial Phase of Substance Abuse Treatment

Addressing Risk Through Community Treatment for Infectious Disease and Opioid Use Disorder Now (ACTION) Among Justice-involved Populations

Maintaining Independence and Sobriety Through Systems Integration, Outreach, and Networking

Medication Treatment for Opioid Use Disorder in Expectant Mothers: Conceptual Model Assessments Sub-study

Prevention of Stimulant-Induced Euphoria With an Opioid Receptor Antagonist

Matching, Outcomes and Costs in Substance Abuse/Psychiatric Treatment

Motivational Enhancement to Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse - 1