Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 7, 2026, 9:22 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 409–432 of 505 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Abuse Problem Clear all

Conditions: Substance Abuse
Interventions: Coaching; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder, Anxiety Disorders, Substance Abuse
Interventions: Aripiprazole; Drug
Lead sponsor: Creighton University; Other
Eligibility: 19 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Substance Abuse, HIV Infections
Interventions: contingency management; Behavioral
Lead sponsor: UConn Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Hartford, Connecticut

Conditions: Diabetes Mellitus, Type 2, Substance-related Disorders
Interventions: Referral to Treatment, Brief Intervention; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 134 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Methamphetamine Dependence, Methamphetamine Abuse, Substance Abuse
Interventions: Perindopril, Placebo, Candesartan; Drug
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 55 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Head and Neck Cancer, Alcohol Use, Unspecified
Interventions: Alcohol Cessation Text Messages, Usual Care; Behavioral
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years and older
Enrollment: 126 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Manhasset, New York

Conditions: HIV Infections, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Depression, Substance Abuse
Interventions: Twinrix, Enhanced treatment as usual; Drug · Behavioral
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 236 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2012
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
Interventions: Varenicline, Placebo; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Drug Addiction, Stimulant Dependence, Opiate Dependence, Alcohol Dependence, Substance Abuse
Interventions: Community Reinforcement and Family Training, Treatment Entry Training, 12- step Al/Nar- Anon Facilitation; Behavioral
Lead sponsor: Treatment Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Substance Abuse
Interventions: Intergenerational culturally adapted curriculum; Other
Lead sponsor: University of New Mexico; Other
Eligibility: 8 Years to 11 Years
Enrollment: 266 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2019
U.S. locations: 3
States / cities: Jemez Pueblo, New Mexico • Mescalero, New Mexico • Pinehill, New Mexico

Conditions: Substance Use Disorder
Interventions: Mindful Awareness in Body-oriented Therapy; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older · Female only
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Kirkland, Washington

Conditions: Substance Abuse, Substance Use Disorders, Prevention, Legislation, Use of Research Evidence
Interventions: Intervention: RPC Group, Active Comparator: Control Group; Behavioral
Lead sponsor: Penn State University; Other
Eligibility: Not listed
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: University Park, Pennsylvania

Conditions: Alcohol-Related Disorders, Alcohol Use Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse
Interventions: Adaptive Tailored Intervention, Consequence-based Intervention, Tailored, not adaptive, based Intervention, Assessment only; Behavioral · Other
Lead sponsor: Northwell Health; Other
Eligibility: 21 Years to 65 Years
Enrollment: 174 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Great Neck, New York

Conditions: Substance Abuse
Interventions: Strengths-based case management, Case management plus facilitated treatment alliance; Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years and older
Enrollment: 726 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2013
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Alcohol Abuse
Interventions: MI/Family Check-up, MI only; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 13 Years to 17 Years
Enrollment: 208 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2008
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Domestic Violence, Alcohol Abuse
Interventions: Motivational Enhancement Therapy; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 64 Years · Female only
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Post-Traumatic Stress Disorder, Substance Use Disorders
Interventions: Seeking Safety; Behavioral
Lead sponsor: University of New Mexico; Other
Eligibility: 18 Years and older
Enrollment: 291 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Española, New Mexico

Conditions: Substance Abuse
Interventions: Contingency management; Behavioral
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Domestic Violence, Substance Abuse, Parenting
Interventions: Fathers for Change, Individual Drug Counseling; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 60 Years · Male only
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Substance Abuse
Interventions: STaRS; Other
Lead sponsor: Polaris Health Directions; Industry
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Camden, New Jersey

Conditions: HIV, Substance Abuse
Interventions: Women's Health CoOp (WHC); Behavioral
Lead sponsor: RTI International; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 564 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Research Triangle Park, North Carolina

Conditions: Substance Abuse, Primary Medical Care
Interventions: On-site vs. referral methods of care; Procedure
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years and older
Enrollment: 800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Ends 2004
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Prevent Disorders in Children Adopted From Foster Care
Interventions: ADAPT; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 5 Years to 14 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2018
U.S. locations: 5
States / cities: Los Angeles, California • Torrance, California • Burtonsville, Maryland + 1 more

Conditions: Substance Abuse, Traumatic Stress
Interventions: Trauma-focused Substance Abuse Intervention; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 13 Years to 19 Years
Enrollment: 117 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Los Angeles, California

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Telephone Coaching of Family Members of Veterans With Substance Abuse Problems

Abilify Therapy for Reducing Comorbid Substance Abuse

Healthy Activities for Prize Incentives

Screening, Brief Intervention, and Referral to Treatment in Primary Care

An ACE Inhibitor (Perindopril) or an Angiotensin Receptor Blocker (Candesartan) as a Treatment for Methamphetamine Dependence

Alcohol Cessation Among Head and Neck Cancer Survivors

Effectiveness of the Screen, Test, Immunize, Reduce Risk, and Refer (STIRR) Intervention for People With Both a Mental and Substance Abuse Disorder

Varenicline vs Placebo for the Treatment of Methamphetamine Dependence

CRAFT Behavior Therapy: Treatment Entry Component

Family Listening Program: Multi-Tribal Implementation and Evaluation

Mindful Awareness in Body-Oriented Therapy for Women's Substance Abuse Treatment

Testing Strategies to Improve Substance Misuse Prevention Research Use in State Policy Contexts

Tailored Mobile Text Messaging to Reduce Problem Drinking

Intervention to Reduce Injection Drug Use

Brief Intervention for Families of Teens Treated in the Emergency Department for an Alcohol-Related Event

Brief Intervention for Problem Drinking and Partner Violence

Effectiveness of Peer-Delivered Trauma-Specific Treatment

Contingency Management for Attendance - 2

Fathers for Change for Men With Co-occurring Domestic Violence and Substance Abuse

Substance Treatment and HIV Testing and Referral System

Implementation Research for Vulnerable Women in South Africa

Onsite Versus Referral Models of Primary Care for Substance Abusing Patients

Adoption-specific Treatment Prevention Pilot Trial

An Integrated Treatment for Comorbid PTSD and Substance Abuse in Adolescents