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ClinicalTrials.gov public records Last synced Nov 7, 2026, 9:33 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 433–456 of 505 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Abuse Problem Clear all

Conditions: Substance Abuse
Interventions: Not listed
Lead sponsor: George Mason University; Other
Eligibility: 12 Years to 14 Years
Enrollment: 245 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2018
U.S. locations: 2
States / cities: New Haven, Connecticut • Fairfax, Virginia

Conditions: Psychosis, Substance Use Disorders
Interventions: Clozapine, Olanzapine; Drug
Lead sponsor: Augusta University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Evans, Georgia

Conditions: Methamphetamine Abuse, Methamphetamine Dependence, Substance Abuse
Interventions: Placebo, N-acetylcysteine; Drug
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 55 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Pregnancy, Drug Abuse
Interventions: Maternal fetal monitoring; Device
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid Use Disorder
Interventions: NTX/BUP, NTX/PBO-B, PBO-N/PBO-B; Drug
Lead sponsor: Alkermes, Inc.; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 380 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 20
States / cities: Oceanside, California • Orange, California • Lauderhill, Florida + 17 more

Conditions: Cocaine Abuse, Cocaine Dependence, Opiate Dependence, Alcohol Dependence, Substance Abuse
Interventions: modafinil, d-amphetamine, L-Dopa, Naltrexone; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 60 Years
Enrollment: 7,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Prescription Drug Abuse, Substance Abuse, Substance Use (Drugs, Alcohol)
Interventions: LST High School Hybrid; Behavioral
Lead sponsor: National Health Promotion Associates, Inc.; Industry
Eligibility: 14 Years to 18 Years
Enrollment: 1,804 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: White Plains, New York

Conditions: Neonatal Abstinence Syndrome
Interventions: Stochastic Vibrotactile Stimulation (SVS); Device
Lead sponsor: Elisabeth B Salisbury; Other
Eligibility: 1 Hour to 18 Months
Enrollment: 208 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Substance Use Disorders
Interventions: Critical Time Intervention-Residential (CTI-R), Enhanced Usual Discharge Services-Residential; Behavioral
Lead sponsor: New York University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: New York, New York

Conditions: Schizophrenia, Drug Abuse, Anxiety Disorder, Bipolar Disorder, Major Depression
Interventions: Not listed
Lead sponsor: Advanced Clinical Laboratory Solutions, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: Substance-Related Disorders
Interventions: Experimental memory training, Comparator memory training 1, Comparator memory training 2; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Prevention Harmful Effects
Interventions: Tailored computer based intervention, Tailored computer intervention; Other
Lead sponsor: University of Rhode Island; Other
Eligibility: 10 Years to 14 Years
Enrollment: 4,158 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Kingston, Rhode Island

Conditions: Opiate Substitution Treatment
Interventions: Standard Medical Management (SMM); Behavioral
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years and older
Enrollment: 239 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Substance Abuse
Interventions: Enhanced Replicating Effective Programs (Enhanced REP), Standard implementation; Behavioral
Lead sponsor: Wayne State University; Other
Eligibility: 14 Years to 99 Years
Enrollment: 825 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Substance-Related Disorders
Interventions: Behavior Therapy; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 422 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2002
U.S. locations: 5
States / cities: New York, New York • Eugene, Oregon • Portland, Oregon + 2 more

Conditions: Craving, Self Efficacy, Affective; Reaction, Substance Abuse
Interventions: CARESS, Isometric Exercise; Behavioral
Lead sponsor: Inova Health Care Services; Other
Eligibility: 18 Years and older
Enrollment: 96 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Fairfax, Virginia

Conditions: Schizophrenia
Interventions: Paliperidone; Drug
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 64 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 1
States / cities: Catonsville, Maryland

Conditions: Substance Abuse
Interventions: Live teleconference supervision, Taped Review Supervision; Behavioral
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 75 Years
Enrollment: 91 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: New York, New York

Conditions: HIV, Substance Abuse, HIV Infections
Interventions: Intensive Case Management; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 127 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 2
States / cities: New Haven, Connecticut • Waterbury, Connecticut

Conditions: Nicotine Dependence
Interventions: Contingency Management; Behavioral
Lead sponsor: UConn Health; Other
Eligibility: 18 Years and older · Male only
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Alcohol Drinking, Marijuana Smoking
Interventions: MI/CBT, RT/SU; Behavioral
Lead sponsor: University of Rhode Island; Other
Eligibility: 14 Years to 19 Years
Enrollment: 205 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2011
U.S. locations: 1
States / cities: Cranston, Rhode Island

Conditions: Substance-Related Disorders
Interventions: Standard Cognitive Behavioral Treatment, Culturally Adapted Cognitive-Behavioral Treatment; Behavioral
Lead sponsor: University of Utah; Other
Eligibility: 13 Years to 18 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Human Immunodeficiency Virus, Substance Abuse, Intravenous
Interventions: BRIDGE; Other
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 616 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance-Related Disorders, Drug Addiction, Substance Abuse
Interventions: Home-Based Intervention, Educational Group; Behavioral
Lead sponsor: Treatment Research Institute; Other
Eligibility: 12 Years to 19 Years
Enrollment: 286 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Minneapolis, Minnesota

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Parent-Adolescent Interactions and Adolescent Development

Clozapine Versus Olanzapine as Treatment for Comorbid Psychotic Disorder and Substance Use Disorder

NAC as a Potential Treatment for Methamphetamine Dependence

Fetal Neurobehavior in Non-methadone Maintained Women in Substance Abuse Treatment

Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension)

Substance Abuse Pre-Treatment Screening Study

A High School Program for Preventing Prescription Drug Misuse

Efficacy and Outcomes of a Non-Pharmacological Intervention for Neonatal Abstinence Syndrome

Intervention for Persons Leaving Residential Substance Abuse Treatment

A Pilot, Proof-of-concept Cohort Study of the Prevalence of Comorbid Mental Illness and Substance Abuse

Effects of Repeated Memory Training on Memory Function and Addiction Related Processes

Tailored Interventions to Prevent Substance Abuse

Buprenorphine and Substance Abuse Services for Prescription Opioid Dependence

Preventing Substance Use Among Youth

Motivational Interviewing to Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse - 1

CARESS: An Investigation of Effects of CARESS

Long Acting Paliperidone in Dually Diagnosed People With Schizophrenia: An Open-label Pilot Study

Training Clinicians in Motivational Interviewing

Transitions: Linkages From Jail To Community

Smoking Cessation in Substance Abuse Treatment Patients: A Feasibility Study

Motivation and Skills for Delta-9-tetrahydrocannabinol/Ethanol (THC/ETOH+) Teens in Jail

Validating Interventions for Diverse Adolescents

BRIDGE: Improving HIV Service Delivery for People Who Inject Drugs

Home-Based Program to Help Parents of Drug Abusing Adolescents