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ClinicalTrials.gov public records Last synced Nov 7, 2026, 9:58 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 481–504 of 505 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Abuse Problem Clear all

Conditions: Substance Abuse Disorder
Interventions: eGet; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 85 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cocaine Dependence, Depression
Interventions: Placebo, Mirtazapine; Other · Drug
Lead sponsor: Boston University; Other
Eligibility: 18 Years to 64 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Chronic Illness
Interventions: Not listed
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 258 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Glen Burnie, Maryland

Conditions: Methamphetamine Dependence
Interventions: Not listed
Lead sponsor: University of Nebraska; Other
Eligibility: 18 Years and older
Enrollment: 133 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 2
States / cities: Grand Island, Nebraska • Omaha, Nebraska

Conditions: Depression, Anxiety, Insomnia, Substance Abuse
Interventions: TES Treatment, TES-SHAM Treatment; Device
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years to 65 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Belle Mead, New Jersey

Conditions: Combat Disorders, Stress Disorders, Post-Traumatic, Depression, Substance-Related Disorders
Interventions: telephone-administered motivational interviewing, control; Behavioral
Lead sponsor: San Francisco Veterans Affairs Medical Center; Federal
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Substance Abuse, Risk Behaviors
Interventions: Parenting Mindfully Program, Parent Education Program; Behavioral · Other
Lead sponsor: George Mason University; Other
Eligibility: 12 Years to 16 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: Fairfax, Virginia

Conditions: Anxiety Disorders, Complex Regional Pain Syndrome Type II, Depressive Disorders, Post-Traumatic Stress Disorder, Substance Abuse
Interventions: Regional Anesthesia, Standard Pain Management Protocol; Procedure
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: Not listed
Enrollment: 386 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2014
U.S. locations: 3
States / cities: Bethesda, Maryland • Philadelphia, Pennsylvania • Fort Sam Houston, Texas

Conditions: Substance-Related Disorders, Mental Disorders
Interventions: Cognitive Remediation Therapy - Standard, Cognitive Remediation Therapy plus Contingency Management; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Substance Abuse
Interventions: Computer Counseling, Standard Care; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 14 Years to 17 Years
Enrollment: 83 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Substance Abuse, Criminal Behavior
Interventions: SCF Supervision, Parole-as-Usual; Behavioral
Lead sponsor: Botec Analysis, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 77 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Toms River, New Jersey

Conditions: Methamphetamine, Amphetamine Dependence, Pharmacogenetics, Methamphetamine Dependence, Substance Abuse
Interventions: Bupropion; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Substance Abuse
Interventions: Motivational interviewing, Strengths-Based Case Management; Behavioral
Lead sponsor: Wright State University; Other
Eligibility: 18 Years and older
Enrollment: 678 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2008
U.S. locations: 1
States / cities: Dayton, Ohio

Conditions: Post Traumatic Stress Disorders, Unsafe Sex, Substance Use Disorders
Interventions: Cognitive Processing Therapy-Cognitive; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Toppenish, Washington

Conditions: Intimate Partner Violence, Substance Abuse/Addiction, Child Maltreatment
Interventions: Fathers for Change, Parent Education; Behavioral
Lead sponsor: University of South Florida; Other
Eligibility: 18 Years and older · Male only
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: St. Petersburg, Florida

Conditions: Substance Abuse
Interventions: Brief Strategic Family Therapy (BSFT), Treatment as Usual; Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 12 Years to 17 Years
Enrollment: 480 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2011
U.S. locations: 7
States / cities: Tucson, Arizona • Tarzana, California • Thornton, Colorado + 4 more

Conditions: Substance Abuse, Exercise
Interventions: contingency management; Behavioral
Lead sponsor: UConn Health; Other
Eligibility: 55 Years to 75 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Cocaine Dependence
Interventions: Oxytocin, Saline; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Bipolar Disorder, Substance Dependence
Interventions: Behavior Therapy; Behavioral
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: HIV, AIDS, Substance Abuse
Interventions: Retention Clinic; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 360 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2021
U.S. locations: 2
States / cities: Miami, Florida • Atlanta, Georgia

Conditions: Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder, Cannabis Use Disorder
Interventions: Dronabinol, Cannabis; Drug
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years to 50 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Genetic Underpinning of Substance Abuse, Polymorphism-genetic, Drug Abuse/Dependence, Opiod-Related Disorders
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years and older
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Substance Use, Child Maltreatment
Interventions: Reinforcement for drug & alcohol abstinence, Parenting intervention, Treatment as usual (TAU); Behavioral
Lead sponsor: University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2020
U.S. locations: 1
States / cities: Columbia, South Carolina

Conditions: Alcohol Abuse
Interventions: AGATE, SASED; Other
Lead sponsor: Talaria, Inc; Industry
Eligibility: 21 Years to 55 Years
Enrollment: 136 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Albuquerque, New Mexico

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Improving Substance Abuse Counseling Adherence Using Web-based Videoconferencing

Efficacy of Mirtazapine in Depressed Cocaine Dependent Subjects

Structuring the Integration of Care Management Services For Medicaid Enrollees Recipients With Chronic Illness, Substance Abuse Problems and Possible Psychiatric Disorders

Risk and Protective Factors for Rural Methamphetamine Dependence

Nexalin Therapy as a Viable Adjunctive Treatment for Substance Use Disorders

Motivational Interviewing to Engage Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) Veterans in Mental Health Treatment

Parenting Mindfully Study

Regional Anesthesia Military Battlefield Pain Outcomes Study

Performance-based Reinforcement to Enhance Cognitive Remediation Therapy

Computer-Assisted Brief Intervention

An Evaluation of the NJSPB SCF Project for Opioid-Involved High-Risk Parolees

Study of Medical Treatment for Methamphetamine Addiction

Reducing Barriers to Drug Abuse Treatment Services

Cognitive Processing Intervention for Trauma, HIV/STI Risks, and Substance Use Among Native Women

Intimate Partner Violence and Fatherhood Intervention in Residential Substance Abuse Treatment

Brief Strategic Family Therapy for Adolescent Drug Abusers

Substance Use and Fitness

Oxytocin in Cocaine Dependence

Modifying Group Therapy for Bipolar Substance Abusers - 1

Project RETAIN: Providing Integrated Care for HIV-Infected Crack Cocaine Users

Cannabis and Schizophrenia: Self-Medication and Agonist Treatment

Impact of Delta Opioid Receptor Gene (OPRD1) Variations on Treatment Outcome in African Americans

Concurrent Treatment of Substance Abuse and Child Maltreatment

Adaptive Goal-Directed Adherence Tracking and Enhancement