Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 7, 2026, 6:39 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 505 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Abuse Problem Clear all

Conditions: Alcohol Use Disorder, Alcohol Abuse, Alcoholism, Drinking Behavior, Drinking Problem
Interventions: Active Transcranial Magnetic Simulation, Sham; Device
Lead sponsor: VA Palo Alto Health Care System; Federal
Eligibility: 25 Years to 75 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Substance Abuse
Interventions: Advisor-Teller Money Manager, FIT; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2009
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Substance Abuse
Interventions: Computer-based Motivational Interviewing, Time control; Behavioral
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 143 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Alcohol Abuse, Alcohol Dependence, Substance Abuse, Substance Dependence
Interventions: Motivational Enhancement Therapy, Education; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 242 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Bipolar Disorder, Depression, Anxiety Disorders, Schizophrenia, Tourette's Syndrome, Brain Diseases
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: Not listed
Enrollment: 2,161 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1990 – 2017
U.S. locations: 3
States / cities: Washington D.C., District of Columbia • Bethesda, Maryland • Fairfax, Virginia

Conditions: Depression, Suicidality, Substance Abuse, HIV, Minority Stress
Interventions: Expressive Writing (EW) Intervention, Self-Affirmation (SA) Intervention, Control; Behavioral · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 29 Years
Enrollment: 108 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 3
States / cities: New Haven, Connecticut • Worcester, Massachusetts • Johnson City, Tennessee

Conditions: Substance Abuse
Interventions: Caregiver Contingency Management + Usual Drug Court Treatment, Usual Drug Court Treatment; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 13 Years to 89 Years
Enrollment: 53 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 2
States / cities: Dayton, Ohio • Corpus Christi, Texas

Conditions: Substance Abuse Disorder
Interventions: Not listed
Lead sponsor: Power Life Sciences Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Substance Use, Sexual Risk Behaviors
Interventions: Risk Reduction Therapy for Adolescents, Usual services; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 12 Years to 17 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Substance Use Disorders
Interventions: Home-based Continuing Care, Services as Usual; Behavioral
Lead sponsor: Treatment Research Institute; Other
Eligibility: 19 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Hepatitis C, Depressive Disorder, Major, Depressive Disorder, Depression, HIV Infections
Interventions: Hepatitis C educational support groups, Cognitive Behavioral Therapy skills based group sessions; Behavioral
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 21 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Adolescent Substance Use
Interventions: Not listed
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 12 Years to 18 Years
Enrollment: 51 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Substance Abuse
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 21 Years to 50 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2015
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Bipolar Disorder, Mania, Substance Abuse, Substance Dependence
Interventions: Divalproex ER; Drug
Lead sponsor: Creighton University; Other
Eligibility: 19 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Opioid Dependence, Substance Abuse Disorders, Complex Medical Patients, Primary Care Patients With Chronic Conditions
Interventions: MOUD "Plus" Intervention (treatment as usual + coordinated counseling and referral to community based peer), Treatment As Usual (primary care with low threshold MOUD prescribing); Behavioral
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Alcohol Dependence, Bipolar Disorder
Interventions: Acamprosate; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Substance Abuse
Interventions: Home-based Family Therapy, office-based family therapy, WHE; Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: 8 Years and older
Enrollment: 183 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2015
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Substance Abuse
Interventions: Not listed
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 2
States / cities: Boston, Massachusetts • New York, New York

Conditions: Aggression, Substance-Related Disorders
Interventions: MI-CBT, MI-CBT+CC, E-TAU; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Usual Aftercare, Oxford House, Therapeutic Community
Interventions: Residential; Other
Lead sponsor: DePaul University; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2014
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Drug Use, Alcohol Use
Interventions: SBIRT+; Behavioral
Lead sponsor: Treatment Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 3
States / cities: Philadelphia, Pennsylvania

Conditions: Substance Abuse Disorders
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years and older
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: HIV/AIDS, Substance Abuse
Interventions: Directly Administered Antiretroviral Therapy; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2006
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Adolescent Substance Abuse
Interventions: Not listed
Lead sponsor: The National Center on Addiction and Substance Abuse at Columbia University; Other
Eligibility: 13 Years to 17 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 1
States / cities: New York, New York

Search by objective public record fields.

Developing Functional Connectivity-Guided TMS for Alcohol Use Disorder

Clinical Trial of Abstinence-Linked Money Management

Computer-based Brief Intervention for Perinatal Substance Abuse

Efficacy Trial of Warrior Check-Up

Brain Tissue Collection for Neuropathological Studies

Development and Preliminary Trial of a Brief, Portable Health Intervention for Rural Sexual Minority Emerging Adults

Increasing Caregiver Engagement in Juvenile Drug Courts

Examining Clinical Research Participation for Substance Abuse Disorder Patient

Targeting HIV Risk Behaviors in Juvenile Drug Court-Involved Youth

Home-based Continuing Care for Young Adults Leaving Residential Substance Abuse Treatment

Prevention of Depression in HIV/HCV Co-infected Substance Abuse Patients

The Neuroeconomics of Behavioral Therapies for Adolescent Substance Abuse

Methylphenidate Studies for Drug Abuse Vulnerability Molecular Genentics

Depakote ER Therapy for Mania Comorbid With Substance Abuse

The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care

Open Label Trial of Acamprosate in Bipolar Alcoholics

Adolescent Involvement in Parental Substance Abuse Treatment

A Phased-Implementation Feasibility and Proof-of-Concept Study to Assess Incorporating the NIDA CTN Common Data Elements (CDEs) Into the Electronic Health Record (EHR) in Large Primary Care Settings ("CDE-EHR-PC" Study), Phase 2

Preventing Violence Among Veterans in Substance Use Disorder Treatment

Evaluating Alternative Aftercare Models for Ex-Offenders

Integrating Substance Abuse Assessment & Intervention in Primary Care Settings

Study of Smoking Abstinence

Directly Observed Antiretroviral Therapy Among Active Drug Users

Learning Effective Approaches to Prevention