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ClinicalTrials.gov public records Last synced Nov 7, 2026, 6:58 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 97–120 of 505 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Abuse Problem Clear all

Conditions: Alcohol Drinking, Smoking, Marijuana Smoking
Interventions: Project ALERT; Behavioral
Lead sponsor: Pacific Institute for Research and Evaluation; Other
Eligibility: Not listed
Enrollment: 8,338 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Addiction, Substance Abuse, Cannabis Use Disorder, Cannabis Use, Cannabis Dependence, Cannabis Abuse
Interventions: Breathwork workshop; Behavioral
Lead sponsor: Elias Dakwar; Other
Eligibility: 18 Years to 70 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: New York, New York

Conditions: Prevention, Family Function, Substance Use, Sexual Behavior
Interventions: Familias Unidas; Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 12 Years and older
Enrollment: 746 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Substance Abuse Disorder
Interventions: PRSS (Peer Recovery Support Specialist); Other
Lead sponsor: West Virginia University; Other
Eligibility: 18 Years and older
Enrollment: 500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Morgantown, West Virginia

Conditions: Substance Use Disorders, Drug Abuse, Drug Addiction, Substance Abuse, Drug Use Disorders, Drug Dependence, Substance Addiction
Interventions: Treatment as Usual (TAU), TAU+CBT4CBT; Behavioral
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Adolescent Behaviors, Substance Abuse
Interventions: LIFT (Parent Information); Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 11 Years to 15 Years
Enrollment: 318 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
Interventions: Placebo, Rivastigmine; Other · Drug
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 55 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Prevention Harmful Effects
Interventions: computer-facilitated brief intervention; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 9 Years to 18 Years
Enrollment: 871 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 5
States / cities: Boston, Massachusetts • East Boston, Massachusetts • Lexington, Massachusetts

Conditions: Substance Abuse, Depression
Interventions: SHADE therapy + CONNECT FaceBook support; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 65 Years
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Substance Use Disorders, Posttraumatic Stress Disorder
Interventions: Prolonged Exposure Therapy, Prolonged Exposure therapy + VR/ER; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Cannabis Use Disorder
Interventions: lorcaserin, Fitbit Charge HR; Drug · Other
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 60 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: HIV Infection, Substance Abuse
Interventions: empowerment theory-based small group discussion, individual resilience counseling; Behavioral
Lead sponsor: Nova Southeastern University; Other
Eligibility: 18 Years to 55 Years · Male only
Enrollment: 515 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 2
States / cities: Miami Beach, Florida • Wilton Manors, Florida

Conditions: Substance Use Disorders, Substance Abuse, Substance Use, Substance Dependence
Interventions: The Bridge; Device
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 99 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Substance Abuse, HIV Infections
Interventions: Bupropion, Placebo; Drug
Lead sponsor: San Francisco Department of Public Health; Government
Eligibility: 18 Years to 60 Years · Male only
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Substance Abuse, HIV
Interventions: Tool to provide re-entry support and improve linkage to healthcare and social services; Behavioral
Lead sponsor: Temple University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Opioid Use, Traumatic Injury, Adolescent Behavior, Substance Abuse Disorder
Interventions: Not listed
Lead sponsor: Indiana University; Other
Eligibility: 12 Years to 20 Years
Enrollment: 123 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Substance Abuse, HIV Risk, Shame, Guilt, Empathy, Criminogenic Thinking
Interventions: Impact of Crime Modules, TAU; Behavioral
Lead sponsor: George Mason University; Other
Eligibility: 18 Years and older · Male only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016
U.S. locations: 1
States / cities: Fairfax, Virginia

Conditions: Substance Abuse
Interventions: CASPAR/Treatment Planning; Behavioral
Lead sponsor: Treatment Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 352 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2010
U.S. locations: 7
States / cities: Camden, New Jersey • Cape May Court House, New Jersey • Collingswood, New Jersey + 4 more

Conditions: Substance-Related Disorders, Mental Disorders
Interventions: RecoveryTrack - Extended Care (RT-E); Behavioral
Lead sponsor: Treatment Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 139 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 4
States / cities: Collingswood, New Jersey • Marlton, New Jersey • Philadelphia, Pennsylvania

Conditions: Substance Abuse, HIV Infections
Interventions: mirtazapine, placebo; Drug
Lead sponsor: San Francisco Department of Public Health; Government
Eligibility: 18 Years to 60 Years · Male only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Substance Abuse, Contingency Management, Exercise
Interventions: Contingency Management; Behavioral
Lead sponsor: UConn Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: Hartford, Connecticut

Conditions: Depression, Anxiety, Alcohol Abuse, Tobacco Abuse
Interventions: Savings program; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 678 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Stanford, California

Conditions: Cocaine Dependence
Interventions: Contingency Management; Behavioral
Lead sponsor: UConn Health; Other
Eligibility: 18 Years and older
Enrollment: 443 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2009
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Alcohol Abuse
Interventions: Family Check Up, Psychoeducation; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 12 Years to 18 Years
Enrollment: 104 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Providence, Rhode Island

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An Effectiveness Trial of Project ALERT

Breathwork-assisted Treatment for Cannabis Use Disorder

Familias Unidas: Preventing Substance Abuse in Hispanic Youth

Machine Learning Technology in Predicting Relapse and Implementing Peer Recovery Intervention Before Drug Use Occurs

CBT4CBT for Women in Residential Treatment for Substance Use Disorders

Linking Families Together Study- A Randomized Trial to Raise Parental Monitoring

Rivastigmine as a Treatment for Methamphetamine Dependence

Computerized Alcohol Screening for Children and Adolescents (cASCA) in Primary Care

CONNECT for Depressed Cannabis Users Trial

Post-traumatic Stress Disorder (PTSD), Addiction, and Virtual Reality

Use of a Mobile Health Sensor in an Open Label Trial of Lorcaserin for the Treatment of Cannabis Use Disorder

Risk Reduction for Urban Substance Using Men Who Have Sex With Men (MSM)

Can The Bridge Transition Opiate Use Disorder Patients in Stable Recovery From Buprenorphine to Naltrexone

Acceptability of Pharmacologic Treatment for Methamphetamine Dependence Among MSM

Testing a Mobile Health Application to Improve HIV Prevention and Substance Use Treatment Among Women Involved in the Carceral System

Opioid Use After Traumatic Injury in Adolescents

Victim Impact Modules for Jail Inmates

Linking Services to Patient Needs for Improved Patient Outcomes (CASPAR)

Clinical Monitoring to Facilitate Continuous Care for Substance Abusing Clients

Mirtazapine to Reduce Methamphetamine Use Among MSM With High-risk HIV Behaviors

Reinforcing Exercise in Substance Abusing Patients

The EARN-Health Trial of Financial Savings and Health

Enhanced and Attendance-based Prize CM in Community Settings

Family Check-Up for Adolescents and Siblings