Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 7, 2026, 7:23 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 121–144 of 505 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Abuse Problem Clear all

Conditions: Stimulant Use Disorder
Interventions: Smartphone digital therapeutic system; Device
Lead sponsor: DynamiCare Health; Industry
Eligibility: 18 Years and older
Enrollment: 270 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Bipolar Disorder, Major Depressive Disorder, Substance Abuse
Interventions: Pregnenolone; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 70 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Buprenorphine, HIV, Drug Abuse, Drug Addiction, Drug Dependence, Drug Use Disorders, Drug Use Disorder, Substance Abuse, Opiate Addiction, Substance-related Disorders
Interventions: Services will be provided at one site, Services remain dispersed; i.e., not centralized to one-location or provider.; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Alcohol Dependence, Alcohol Abuse
Interventions: Motivational Interviewing, Spirit-Only Motivational Interviewing, Self-Change; Behavioral · Other
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 89 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: New York, New York

Conditions: Alcohol Abuse
Interventions: eHealth Coping Skills Training, eHealth Usual Web Care, Coach Support; Behavioral
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 18 Years and older · Female only
Enrollment: 456 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Substance-Related Disorders
Interventions: Motivational Enhancement Therapy; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 12 Years to 21 Years
Enrollment: 170 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2010
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Substance Abuse
Interventions: Nicotine Replacement Treatment (NRT), Brief Advice, Contingency Management, Non-Contingent Reinforcement; Drug · Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years and older
Enrollment: 340 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Adolescent Substance Use
Interventions: Family Check-up, Parent psychoeducation; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 12 Years to 16 Years
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Substance Abuse, Chronic Pain
Interventions: Physician coaching; Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 53,132 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Hypertension, Substance Abuse, Asthma, Depression
Interventions: Primary care redesign; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 816 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 10
States / cities: Birmingham, Alabama • Martinez, California • San Francisco, California + 6 more

Conditions: Substance Abuse
Interventions: Project ALERT, Getting to Outcomes; Behavioral
Lead sponsor: RAND; Other
Eligibility: 11 Years to 70 Years
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Substance Abuse
Interventions: Contingency Management, Probation as Usual; Behavioral
Lead sponsor: Chestnut Health Systems; Other
Eligibility: 12 Years to 18 Years
Enrollment: 310 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 14
States / cities: Burley, Idaho • Caldwell, Idaho • Gooding, Idaho + 11 more

Conditions: Substance Use, Delinquency
Interventions: Multidimensional Family Therapy (MDFT), Adolescent Residential Treatment; Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 13 Years to 17 Years
Enrollment: 113 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2000 – 2010
U.S. locations: 2
States / cities: Miami, Florida

Conditions: HIV Infections, Unstable Housing
Interventions: Not listed
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2005
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Substance Abuse
Interventions: Patient-administered screening tool, Patient health navigator-administered screening tool, Patient health navigator-assisted linkage to treatment; Behavioral
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older
Enrollment: 3,358 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: New York, New York

Conditions: Cocaine Dependence, Alcohol Dependence
Interventions: VIVITROL (Naltrexone extended-release injectable suspension), Placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Substance Abuse
Interventions: computer-assisted Screening & Brief Advice, computer-assisted Screening & Brief Advice Plus; Behavioral
Lead sponsor: Treatment Research Institute; Other
Eligibility: 12 Years to 18 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Substance Abuse, Opioid Dependence, Methadone Treatment
Interventions: Oxytocin, Saline Nasal Spray; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older · Male only
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Poly Drug Exposed Pregnancies
Interventions: Not listed
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 41 Years · Female only
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Substance Abuse, Intimate Partner Violence (IPV), HIV Infections, Depression, Anxiety
Interventions: SER Familia; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 12 Years to 100 Years
Enrollment: 400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Substance Abuse
Interventions: cognitive behavioral training; Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Chestnut Hill, Massachusetts

Conditions: Drug Overdose, Opioid-Related Disorders, Drug Addiction, Drug Abuse, Substance Abuse
Interventions: Peer Intervention, naloxone nasal spray kit, Personally-tailored opioid overdose prevention education (information packet); Behavioral · Drug
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Cocaine Dependence
Interventions: Escitalopram, Placebo; Drug
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 160 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Substance Use
Interventions: Push Notifications with Tailored Intervention Content, Push Notifications with Engaging, Non-therapeutic Content, No Push Notifications; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 16 Years to 24 Years
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Search by objective public record fields.

Smartphone Services for Stimulant Use Disorder

Pregnenolone Trial for Depression in Bipolar Disorders or Recurrent Major Depressive Disorder With Substance Abuse

Integration of Buprenorphine Into HIV Clinical Settings - Primary Care Model (PCM)

Project Motion, A Study of Motivational Interviewing to Reduce Heavy or Problematic Drinking

E-Health Coping Skills Training for Women Whose Partner Has a Drinking Problem

Medical Office Intervention for Adolescent Drug Use

Contingency Management for Smoking in Substance Abusers

Substance Use Prevention in Teen Psychiatric Patients

Physician Coaching to Reduce Opioid-related Harms

Linking Former Inmates to Primary Care

Testing ALERT With GTO in Middle Schools

Teen Success Project

Family-based and Adolescent Residential Drug Treatment

Engagement in HIV Primary Care Services

Integrated Care (iCare) at Mount Sinai to Improve Substance Use Diagnosis and Treatment Practices in HIV Clinic Settings

VIVITROL as a Treatment for Cocaine and Alcohol Dependence

Advancing Adolescent Screening and Brief Intervention Protocols in Primary Care Settings

Methadone Oxytocin Option

Fetal Neurobehavior in Poly-drug Dependent Women

SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Families

Substance Abuse Treatment for High Risk Chronic Pain Patients on Opioid Therapy

A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses

Clinical Neurobiology of Serotonin and Addiction

Adaptive Interventions for Prevention/Intervention for Youth Substance Abuse