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ClinicalTrials.gov public records Last synced Nov 7, 2026, 7:38 AM EST

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Showing 169–192 of 505 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Abuse Problem Clear all

Conditions: Social Skills, Self-Criticism, Post-traumatic Stress Disorder, Depression, Alcohol Abuse, Drinking, College, Alcohol Drinking, Alcohol; Harmful Use, Social Stigma, Social Norms, Social Responsibility, Social Behavior, Empathy, Coping Skills, Coping Behavior
Interventions: Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS); Behavioral
Lead sponsor: University of New Hampshire; Other
Eligibility: 18 Years to 24 Years
Enrollment: 1,268 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Durham, New Hampshire

Conditions: Schizophrenia, Schizoaffective Disorder, Substance Abuse, Substance Dependence
Interventions: Quetiapine, Risperidone; Drug
Lead sponsor: Creighton University; Other
Eligibility: 19 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Schizophrenia, Substance Abuse, Cocaine Abuse, Tobacco Use Disorder
Interventions: Various Screening psychiatric and medical assessments; Behavioral
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 64 Years
Enrollment: 523 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2019
U.S. locations: 1
States / cities: Catonsville, Maryland

Conditions: Substance Abuse, Sexual Behavior
Interventions: Patient Navigation (PN) Intervention, Financial Incentives (FI) Intervention; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 18 Years to 99 Years · Male only
Enrollment: 1,930 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Alcoholic, Marijuana Misuse
Interventions: MI/CBT, RT/TU; Behavioral
Lead sponsor: University of Rhode Island; Other
Eligibility: 14 Years to 19 Years
Enrollment: 205 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2011
U.S. locations: 2
States / cities: Cranston, Rhode Island • Kingston, Rhode Island

Conditions: Cocaine-Related Disorders, Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
Interventions: employment-based reinforcement; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 67 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Fetal Alcohol Syndrome, Substance Abuse
Interventions: Brief motivational intervention; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older · Female only
Enrollment: 612 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Substance Abuse
Interventions: Ecologically Based Treatment (EBT), Treatment as Usual (TAU); Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Attention Deficit Hyperactivity Disorder, Substance Abuse
Interventions: Atomoxetine, Placebo; Drug
Lead sponsor: Denver Health and Hospital Authority; Other
Eligibility: 12 Years to 19 Years
Enrollment: 70 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Child Behavior, Parent-Child Relations, Substance Use, Substance Abuse
Interventions: Filming Interactions to Nurture Development, The Healthy Toddler Program; Behavioral
Lead sponsor: University of Oregon; Other
Eligibility: Up to 50 Years
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Antisocial Personality Disorder, Substance Use Disorder
Interventions: Moral Reconation Therapy (MRT); Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: Not listed
Enrollment: 344 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 3
States / cities: North Little Rock, Arkansas • Palo Alto, California • Bedford, Massachusetts

Conditions: Alcohol Abuse
Interventions: Strengths Based Case Management, Motivational Enhancement Therapy, Brief Informational Feedback; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 19 Years to 60 Years
Enrollment: 686 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: Flint, Michigan

Conditions: Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Drug Abuse, Substance Abuse
Interventions: quetiapine fumarate, Matched Placebo, Cognitive-behavioral Therapy; Drug · Behavioral
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Tacoma, Washington

Conditions: Substance-Related Disorders, Substance Use Disorders, Substance Abuse, Intravenous, Substance Withdrawal, Substance Abuse, Opioid-use Disorder, Opioid Use Disorder, Severe, Opioid Use
Interventions: Non invasive VN stimulation (nVNS), Oxygen (15-O) Water, Sham Stimulation; Device · Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Attention Deficit Disorder With Hyperactivity, Conduct Disorder, Substance Abuse
Interventions: Adderall; Drug
Lead sponsor: Jeffrey Newcorn; Other
Eligibility: 7 Years to 12 Years
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance Use Disorders, Opioid Use Disorder, Alcohol Use Disorder, Cocaine Use Disorder, Methamphetamine-dependence
Interventions: EDITOR (CBOT with olfactory stimulants, OFC tasks & remote monitoring of treatment compliance), CBOT with olfactory stimulants & OFC tasks, CBOT Sham; Combination Product
Lead sponsor: Evon Medics LLC; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 3
States / cities: Washington D.C., District of Columbia • Rockville, Maryland

Conditions: Suicide and Depression
Interventions: Observational Study; Other
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 12 Years to 18 Years
Enrollment: 225 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD)
Interventions: Prazosin, Naltrexone, Placebo (Prazosin), Placebo (Naltrexone); Drug
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years to 80 Years
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Alcohol Problem, Chronic Pain, Alcohol Abuse
Interventions: Personalized Feedback Intervention; Behavioral
Lead sponsor: University of Houston; Other
Eligibility: 21 Years and older
Enrollment: 117 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Methamphetamine Abuse, Methamphetamine Dependence
Interventions: Atomoxetine, then Placebo, Placebo, then Atomoxetine; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 50 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Alcohol Abuse
Interventions: Brief Motivational Intervention (BMI), Parent Based Intervention plus booster, Combined brief motivational intervention and parent based intervention plus boosters for both interventions, Assessment only; Behavioral · Other
Lead sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA); NIH
Eligibility: 17 Years to 20 Years
Enrollment: 1,014 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2009
U.S. locations: 1
States / cities: Kingston, Rhode Island

Conditions: Substance Abuse, Child Abuse
Interventions: Parenting Intervention; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1998 – 2003
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Drug Abuse, Alcohol Abuse, Nicotine Dependence
Interventions: iMET, MET; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 12 Years to 21 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2013
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Substance Abuse, Intravenous, HIV, Heroin Dependence, Opioid Dependence, Cocaine Dependence, Amphetamine Dependence
Interventions: Change the Cycle; Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older
Enrollment: 979 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 2
States / cities: Los Angeles, California • San Francisco, California

Search by objective public record fields.

Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking

Seroquel Therapy for Substance Use Disorders Comorbid With Schizophrenia

Screening Protocol for Research Participants

Seek, Test, and Retain. Linkages for Black HIV+, Substance-Using MSM

Skills and Motivation at the Rhode Island Training School (Project SMART) - 1

Employment-based Reinforcement of Naltrexone Ingestion and Abstinence

Fetal Alcohol Damage Prevention Study

Stage 1 Treatment Development With Homeless Mothers

Atomoxetine for Attention Deficit Hyperactivity Disorder in Adolescents With Substance Use Disorder

A Scaleable Video Coaching Intervention for Opioid-using Mothers

Justice-Involved Veterans and Moral Reconation Therapy

Project Health Link: Connecting Patients With Services

Quetiapine for the Reduction of Cocaine Use

Non-Invasive Vagal Nerve Stimulation in Opioid Use Disorders

Brain Indices of Stimulant Treatment in Drug-Naive Youth at Risk for Substance Use Disorder

Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders

Characterizing Inflammatory Profiles and Suicidal Behavior in Adolescents

Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders

PFI for Pain-Related Anxiety Among Hazardous Drinkers With Chronic Pain

Safety Assessment of Atomoxetine With MA IV Administration

Alcohol Early Intervention for Freshmen

Relational Parenting Group for Opioid-addicted Mothers

Trial of Computerized MET for Adolescent Substance Use

Change the Cycle: An RCT to Prevent Injection Initiation