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ClinicalTrials.gov public records Last synced Nov 7, 2026, 7:48 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 193–216 of 505 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Abuse Problem Clear all

Conditions: Substance Abuse
Interventions: Therapeutic Education System (TES), Treatment-as-Usual (TAU); Behavioral
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 75 Years
Enrollment: 507 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 10
States / cities: Danbury, Connecticut • Orlando, Florida • Waipahu, Hawaii + 7 more

Conditions: Bullying, Cyberbullying, Substance Use, Substance Abuse
Interventions: LST MS curriculum+ Bullying/Cyberbulling serious game, LST MS curriculum; Behavioral
Lead sponsor: National Health Promotion Associates, Inc.; Industry
Eligibility: 11 Years to 14 Years
Enrollment: 3,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: White Plains, New York

Conditions: Opiate Addiction
Interventions: Buprenorphine/naloxone, Naltrexone; Drug
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 16 Years to 25 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Divorce, Drug Abuse, Mental Health Disorder
Interventions: New Beginnings Program; Behavioral
Lead sponsor: Arizona State University; Other
Eligibility: 3 Years to 18 Years
Enrollment: 2,415 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Tempe, Arizona

Conditions: Substance Abuse
Interventions: Community Reinforcement Approach (CRA) + HIV prevention, Case Management + HIV Prevention, Motivational Enhancement Therapy (MET) + HIV prevention; Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: 14 Years to 20 Years
Enrollment: 270 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Opioid-use Disorder, Substance Use Disorders
Interventions: Exablate Model 4000 Type 2.0/2.1; Device
Lead sponsor: InSightec; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2027
U.S. locations: 4
States / cities: Tampa, Florida • Baltimore, Maryland • New York, New York + 1 more

Conditions: Opioid-Related Disorders, Hepatitis C (HCV), Human Immunodeficiency Virus (HIV), Drug Overdose, Substance Abuse, Intravenous Drug Usage, Opiate Substitution Treatment, Sexually Transmitted Diseases
Interventions: Health kiosk; Behavioral
Lead sponsor: April M Young; Other
Eligibility: 18 Years and older
Enrollment: 752 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Alcohol-Related Disorders, Alcohol Use Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse
Interventions: Brief Advice, Motivational Interviewing, Behavioral Self-Control Training; Behavioral
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years to 75 Years
Enrollment: 164 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Great Neck, New York

Conditions: Delinquency, Substance Abuse, Self Destructive Behavior
Interventions: Supervision, Observational Supervision; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 12 Years to 18 Years
Enrollment: 328 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2016
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Substance Abuse
Interventions: BHCDS-based recommendations, Non-tailored recommendations; Behavioral
Lead sponsor: Inflexxion, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 140 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Waltham, Massachusetts

Conditions: HIV Infections
Interventions: routine HIV testing; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 621 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 2
States / cities: New Haven, Connecticut • Niantic, Connecticut

Conditions: Substance Use Disorder, Mental Health Disorder
Interventions: LOCI, Internet Based Webinar Leadership Training; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 448 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Substance Abuse, Risk Reduction, RIsky Sexual Behavior
Interventions: Handbook condition, Handbook plus condition; Behavioral
Lead sponsor: Washington State University; Other
Eligibility: 17 Years to 22 Years
Enrollment: 910 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Pullman, Washington

Conditions: Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Interventions: Mobile self-help intervention; Behavioral
Lead sponsor: Rush University Medical Center; Other
Eligibility: 16 Years to 25 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Substance Abuse
Interventions: brief (behavioral therapy), Drop out re-engagement motivational intervention, standard care follow up; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 299 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2009
U.S. locations: 2
States / cities: New Haven, Connecticut

Conditions: Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders, Substance-Related Disorders
Interventions: NRP104; Drug
Lead sponsor: New River Pharmaceuticals; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Smoking Cessation
Interventions: Stepped-Care, Control; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Walnut Creek, California

Conditions: Adolescent Health
Interventions: Not listed
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 15 Years to 22 Years
Enrollment: 4,902 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2010
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Suicide; Trauma, Binge Drinking
Interventions: Common Elements Treatment Approach; Behavioral
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 25 Years to 65 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Whiteriver, Arizona

Conditions: Substance Abuse
Interventions: contingency management, Standard Care; Behavioral · Other
Lead sponsor: UConn Health; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: New Britain, Connecticut

Conditions: HIV, Substance Abuse
Interventions: Not listed
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 29 Years · Male only
Enrollment: 469 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2019
U.S. locations: 7
States / cities: Atlanta, Georgia

Conditions: Transgender Women, Substance Abuse, Hiv
Interventions: Adapted SBIRT-T for transgender women; Behavioral
Lead sponsor: University of Central Florida; Other
Eligibility: 18 Years and older · Male only
Enrollment: 86 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 2
States / cities: Miami, Florida • Orlando, Florida

Conditions: Mentally Ill Persons, Substance Abuse, HIV Infections
Interventions: PATH; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 238 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Substance Abuse
Interventions: Standard Treatment As Usual (TAU), Individual clinician-provided CBT, CBT4CBT; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 164 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: New Haven, Connecticut

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Web-delivery of Evidence-based, Psychosocial Treatment for Substance Use Disorders

An Evidence-based Approach for Bullying Prevention

Comparison of Buprenorphine/Naloxone With Naltrexone in Opioid Dependent Adolescents

Multi-court Trial of NBP to Prevent Substance Abuse and Mental Health Disorders (MTC)

Evaluation of Treatments for Homeless Youths

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)

Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk

Adaptive Interventions for Problem Drinkers

Building Outcomes With Observation-Based Supervision: An FFT Effectiveness Trial

A Clinical Decision Support Tool for Electronic Health Records

Early Versus Delayed Routine HIV Testing in Connecticut Jails

Testing the Leadership and Organizational Change for Implementation (LOCI) Intervention

First Years Away From Home: Letting Go and Staying Connected

Homeless Youth Study - Stepping Stone 2.0

Brief Interventions for Drop-out Re-engagement

Study to Evaluate the Likeability, Safety, and Abuse Potential of NRP 104 in Adults With Histories of Stimulant Abuse

Interventions for Smoking Among Persons in Recovery

Health Behavior in School-Age Children: NEXT Longitudinal Study 2009-2016

My Pathway to Healing

Contingency Management for Persons With Severe Mental Illness

Understanding Substance Use and Incident HIV/STI Among Young Black MSM

To Reach Unrestricted Services for Transgender Women

HIV Prevention Among Substance Abusing SMI

Computer Based Training in Cognitive Behavioral Therapy Web-based