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Showing 1–24 of 593 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Substance Addiction Clear all
Not listed No phase listed Observational Accepts healthy volunteers

Injectable Extended-Release Buprenorphine (XR-B) in a Correctional Setting: Qualitative Interviews

NCT06354465
View directory record Official record
Conditions
Opioid Use Disorder, Criminal Justice, Treatment Adherence and Compliance
Interventions
Not listed
Lead sponsor
Lifespan
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Cranston, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 8, 2024 · Synced Jun 10, 2026, 7:24 AM EDT
Completed Not applicable Interventional

A Placebo-Controlled Study of a Combination of Metyrapone and Oxazepam in Cocaine Addiction

NCT00567814
View directory record Official record
Conditions
Cocaine Dependence, Cocaine Addiction
Interventions
Metyrapone, Oxazepam, Placebo
Drug
Lead sponsor
Embera NeuroTherapeutics, Inc.
Industry
Eligibility
18 Years to 50 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 30, 2008 · Synced Jun 10, 2026, 7:24 AM EDT
Completed Phase 2 Interventional Results available

Varenicline vs Placebo for the Treatment of Methamphetamine Dependence

NCT01011829
View directory record Official record
Conditions
Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
Interventions
Varenicline, Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 13, 2013 · Synced Jun 10, 2026, 7:24 AM EDT
Completed No phase listed Observational

Boston Alcohol Research Collaboration on HIV/AIDS (ARCH) Cohort: The 4F Study

NCT03414411
View directory record Official record
Conditions
HIV Infections, Alcohol Drinking, Substance-Related Disorders, Bone Diseases, Falls Injury, Fractures, Bone, Injuries
Interventions
Not listed
Lead sponsor
Boston University
Other
Eligibility
18 Years and older
Enrollment
251 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 6, 2023 · Synced Jun 10, 2026, 7:24 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

First Face Training Evaluation in Tribal Communities

NCT05998005
View directory record Official record
Conditions
Mental Health, Substance-Related Disorders
Interventions
First Face Training Program
Behavioral
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
14 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
9
States / cities
Bonners Ferry, Idaho • Lapwai, Idaho • Plummer, Idaho + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Jun 10, 2026, 7:24 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Non-Invasive Deep Brain Neuromodulation for Smoking Cessation

NCT07298902
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Low intensity focused ultrasound with active stimulations, low intensity focused ultrasound with sham stimulations
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
20 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Jun 10, 2026, 7:24 AM EDT
Completed Not applicable Interventional Results available

Implementation Science to Reduce the Disparity in Tobacco Treatment Among Individuals With Serious Mental Illness

NCT05952401
View directory record Official record
Conditions
Smoking, Smoking Cessation, Tobacco Use Cessation
Interventions
Usual Care, "Nudges"
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Jun 10, 2026, 7:24 AM EDT
Completed No phase listed Observational

HIV, Buprenorphine, and the Criminal Justice System (STRIDE2)

NCT03583138
View directory record Official record
Conditions
Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, Opiate Addiction, Drug Dependence
Interventions
buprenorphine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 26, 2020 · Synced Jun 10, 2026, 7:24 AM EDT
Completed Not applicable Interventional

fMRI Study of a Dual Process Treatment Protocol With Substance Dependent Adults

NCT01320748
View directory record Official record
Conditions
Substance Abuse, Substance Dependence, Alcohol Abuse, Drug Use, Relapse
Interventions
Dual Processing, Relapse Prevention
Behavioral
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 29, 2018 · Synced Jun 10, 2026, 7:24 AM EDT
Recruiting Phase 1 Interventional

MethaLoad Dose-Finding Study

NCT06877858
View directory record Official record
Conditions
Opioid Use Disorder (OUD)
Interventions
Methadone hydrochloride
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Jun 10, 2026, 7:24 AM EDT
Completed Phase 1Phase 2 Interventional

Open Label Trial of Acamprosate in Bipolar Alcoholics

NCT00330486
View directory record Official record
Conditions
Alcohol Dependence, Bipolar Disorder
Interventions
Acamprosate
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 18, 2008 · Synced Jun 10, 2026, 7:24 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Translational Neuropsychopharmacology Research of Nicotine Addiction

NCT02723162
View directory record Official record
Conditions
Nicotine Dependence, Cigarettes
Interventions
Varenicline (VRN), N-Acetylcysteine (NAC), Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 55 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 17, 2022 · Synced Jun 10, 2026, 7:24 AM EDT
Completed Phase 2 Interventional Results available

Sweet Preference and Alcohol Craving

NCT01296646
View directory record Official record
Conditions
Alcohol Dependence, Alcohol Abuse
Interventions
Naltrexone, Brenda Therapy Sessions, Placebo
Drug · Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 24, 2013 · Synced Jun 10, 2026, 7:24 AM EDT
Completed No phase listed Observational

Immediate Postpartum Nexplanon Placement in Opioid Dependent Women

NCT02657148
View directory record Official record
Conditions
Opiate Addiction, Pregnancy, Contraceptive Behavior, Sexual Behavior
Interventions
Nexplanon (etonogestrel contraceptive implant), Standard postpartum contraceptive care
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 30, 2018 · Synced Jun 10, 2026, 7:24 AM EDT
Completed Not applicable Interventional

Collaboration Leading to Addiction Treatment and Recovery From Other Stresses

NCT04559893
View directory record Official record
Conditions
Opioid-use Disorder, Addiction, Depression, Post-traumatic Stress Disorder
Interventions
Collaborative Care
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years and older
Enrollment
729 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
16
States / cities
Los Angeles, California • Santa Monica, California • Albuquerque, New Mexico + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Jun 10, 2026, 7:24 AM EDT
Not listed Phase 2 Interventional

Distress Tolerance Treatment for Substance Users

NCT01741415
View directory record Official record
Conditions
Substance Dependence
Interventions
SIDI, SC
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
325 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Tarpon Springs, Florida
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Jun 10, 2026, 7:24 AM EDT
Completed Phase 2 Interventional

TDCS to Reduce Craving in Cocaine Addiction- Phase 2 Study

NCT04994821
View directory record Official record
Conditions
Cocaine Use Disorder, Cocaine Dependence
Interventions
transcranial direct current stimulator (tDCS), Cognitive Reappraisal
Device · Behavioral
Lead sponsor
Soterix Medical
Industry
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 17, 2024 · Synced Jun 10, 2026, 7:24 AM EDT
Completed Phase 3 Interventional Results available

Evaluating Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Transitioning From Buprenorphine Maintenance Prior to First Dose of VIVITROL

NCT02696434
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Naltrexone, Placebo, Buprenorphine
Drug
Lead sponsor
Alkermes, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
9
States / cities
Lauderhill, Florida • Oakland Park, Florida • Winfield, Illinois + 6 more
Source: ClinicalTrials.gov public record
Updated Feb 11, 2019 · Synced Jun 10, 2026, 7:24 AM EDT
Completed Not applicable Interventional

Phone Interview to Prevent Recurring Opioid Overdoses

NCT02282306
View directory record Official record
Conditions
Overdose, Opioid-related Disorders, Drug Addiction, Drug Abuse, Substance Abuse, Opioid Use, Unspecified, Opioid Dependence, Drug Overdose
Interventions
TTIP-PRO
Behavioral
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Jun 10, 2026, 7:24 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Effects of Memantine and Bupropion on Acute, Reinforcing, and Conditioned Effects of Cigarettes - 1

NCT00136747
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Memantine, bupropion, placebo
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 20, 2018 · Synced Jun 10, 2026, 7:24 AM EDT
Completed Phase 2 Interventional

Evaluating Alternative Aftercare Models for Ex-offenders

NCT01586689
View directory record Official record
Conditions
Drug/Substance Abuse/Addiction, Alcohol Abuse/Addiction
Interventions
Oxford House, Safe Haven, Usual aftercare
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Jun 10, 2026, 7:24 AM EDT
Completed Phase 4 Interventional

Biomarkers of Injectable Extended Release Naltrexone Treatment

NCT02324725
View directory record Official record
Conditions
Heroin Dependence, Opioid Dependence
Interventions
Naltrexone
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 55 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 11, 2023 · Synced Jun 10, 2026, 7:24 AM EDT
Completed Phase 2 Interventional

Venlafaxine to Reduce Cocaine Dependence in Depressed Individuals

NCT00249483
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Venlafaxine, Placebo
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2005
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 10, 2017 · Synced Jun 10, 2026, 7:24 AM EDT
Completed Not applicable Interventional

Group Therapy for Women Prisoners With Comorbid Substance Use and Depression

NCT00606996
View directory record Official record
Conditions
Substance Abuse, Substance Dependence, Depressive Disorder
Interventions
Group interpersonal psychotherapy (IPT-G), Psychoeducation on co-occurring disorders (PSYCHOED)
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Cranston, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 19, 2025 · Synced Jun 10, 2026, 7:24 AM EDT