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ClinicalTrials.gov public records Last synced Oct 21, 2026, 10:57 AM EDT

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Showing 97–120 of 257 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Substance Misuse Clear all
Completed Early Phase 1 Interventional

Feasibility of the Utilization of Buprenorphine in the Emergency Room to Treat Clinical Opioid Withdrawal

NCT03489161
View directory record Official record
Conditions
Drug Overdose, Opioid Withdrawal, Opioid-use Disorder
Interventions
Buprenorphine
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 65 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 13, 2018 · Synced Oct 21, 2026, 10:57 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Alcohol Misuse, Gut Microbial Dysbiosis and PrEP Care Continuum: Application and Efficacy of SBIRT Intervention

NCT06005298
View directory record Official record
Conditions
Alcohol Use Disorder, Risk Behavior, Health, Dysbiosis, HIV Infections
Interventions
Screening, Brief Intervention, Referral to Treatment (SBIRT)
Behavioral
Lead sponsor
Shirish S Barve
Other
Eligibility
18 Years to 85 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced Oct 21, 2026, 10:57 AM EDT
Recruiting Not applicable Interventional

Mobile Technology to Reduce Teen Substance Misuse

NCT05897164
View directory record Official record
Conditions
Substance Use, Substance Abuse, Suicide, Adolescent
Interventions
WisePath for Teens, Peer Support Services (PSS), Control
Other · Behavioral · Device
Lead sponsor
Evidence-Based Practice Institute, Seattle, WA
Industry
Eligibility
13 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Baltimore, Maryland • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 21, 2026, 10:57 AM EDT
Recruiting Not applicable Interventional

VA Transitional Pain Service Study

NCT06223503
View directory record Official record
Conditions
Chronic Opioid Use
Interventions
Transitional Pain Service
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 21, 2026, 10:57 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Preventing School Exclusion and Opioid Misuse: Effectiveness of the Inclusive Skill-building Learning Approach (ISLA)

NCT06292078
View directory record Official record
Conditions
Middle Schools, School Exclusion, School Community, Teaching Practices, Opioid and Other Substance Misuse
Interventions
Instructional Skill-Building Learning Approach (ISLA)
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
8 Years to 15 Years
Enrollment
5,076 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
3
States / cities
Capitola, California • Yuba City, California • Salem, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 21, 2026, 10:57 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Tailoring Overdose Education for Black Churches

NCT05645016
View directory record Official record
Conditions
Opioid Overdose
Interventions
COEST
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Oct 21, 2026, 10:57 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Understanding the Associations Between Romantic Relationship Conflict, Psychophysiological Responding and Alcohol Misuse Among Emerging Adults

NCT06976528
View directory record Official record
Conditions
Heavy Episodic Drinking
Interventions
Alcohol administration
Other
Lead sponsor
New York University
Other
Eligibility
21 Years to 29 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Oct 21, 2026, 10:57 AM EDT
Recruiting Phase 2 Interventional

Substance Misuse and Family Violence Treatment Fathers

NCT06650267
View directory record Official record
Conditions
Substance Misuse, Violence, Domestic, Child Abuse
Interventions
Fathers for Change (F4C), Individual Drug Counseling (IDC)
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Male only
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
2
States / cities
New Haven, Connecticut • West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 21, 2026, 10:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Community Pharmacists and Opioid Misuse

NCT03149718
View directory record Official record
Conditions
Opioid Misuse
Interventions
Brief Intervention Medication Therapy Management, Standard Medication Counseling (SMC)
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Somerset, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 14, 2019 · Synced Oct 21, 2026, 10:57 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Pharmacodynamic Evaluation of Intramuscular Nalmefene Autoinjector 1.5 mg Compared to Intranasal Narcan 4 mg

NCT06719986
View directory record Official record
Conditions
Opioid Overdose
Interventions
Nalmefene HCl injection, Naloxone HCl intranasal
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 3, 2025 · Synced Oct 21, 2026, 10:57 AM EDT
Recruiting Not applicable Interventional

Social Network Overdose Prevention and Education Intervention

NCT06327061
View directory record Official record
Conditions
Drug Overdose
Interventions
Network overdose prevention, Standard of care health education
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Oct 21, 2026, 10:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Developing and Testing the Opioid Rapid Response System

NCT04589676
View directory record Official record
Conditions
Opioid Overdose
Interventions
Naloxone training
Behavioral
Lead sponsor
Real Prevention, LLC
Industry
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
2
States / cities
Bloomington, Indiana • Clifton, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 7, 2022 · Synced Oct 21, 2026, 10:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Mobile Application for Prescription Drug-Abuse Education (MAPDE)

NCT03165175
View directory record Official record
Conditions
Prescription Drug Abuse (Not Dependent)
Interventions
prescription drug-abuse education smartphone application
Behavioral
Lead sponsor
Naval Health Research Center
Federal
Eligibility
18 Years to 55 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 5, 2019 · Synced Oct 21, 2026, 10:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Hospital Visit as Opportunity for Prevention and Engagement for HIV-Infected Drug Users

NCT01612169
View directory record Official record
Conditions
HIV, AIDS, Substance Abuse, Inpatient
Interventions
Patient Navigation (PN) Group, Patient Navigator Plus Contingency Management (PN+CM) Group
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
801 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
12
States / cities
Birmingham, Alabama • Torrance, California • Miami, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Mar 14, 2016 · Synced Oct 21, 2026, 10:57 AM EDT
Completed Not applicable Interventional

Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement Study

NCT05977881
View directory record Official record
Conditions
HIV Infections
Interventions
CHECKIT!
Other
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years and older
Enrollment
493 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 21, 2026, 10:57 AM EDT
Not yet recruiting Not applicable Interventional

The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study

NCT07216963
View directory record Official record
Conditions
Opioid Use Disorder, Overdose, Drug, Overdose, Substance Use (Drugs, Alcohol)
Interventions
Community Paramedic Standard of Care (CP SOC), CROSSROADS
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
4
States / cities
Miami, Florida • Boston, Massachusetts • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 21, 2026, 10:57 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Trauma-informed Intervention to Reduce Substance Use and to Support Community Transition

NCT06651528
View directory record Official record
Conditions
Substance Use Disorder (SUD)
Interventions
TAU + TRUST, TAU + TRUST + Re-entry Recovery Support, Treatment as Usual (TAU)
Behavioral · Other
Lead sponsor
Michele Staton
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
264 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
4
States / cities
Frankfort, Kentucky • Pewee Valley, Kentucky • Chillicothe, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 21, 2026, 10:57 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Toward Zero Prescribed Opioids for Outpatient General Surgery

NCT05327777
View directory record Official record
Conditions
Opioid Misuse and Addiction, Pain
Interventions
Oxycodone, Zero Opioid Protocol
Drug · Behavioral
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 99 Years
Enrollment
129 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Oct 21, 2026, 10:57 AM EDT
Active, not recruiting Not applicable Interventional

Pain Care at Home to Amplify Function (Pain CHAMP)

NCT05333341
View directory record Official record
Conditions
Opioid Use Disorder, Opioid Misuse, Chronic Pain
Interventions
TCM, TCM plus COPES
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
259 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
3
States / cities
Little Rock, Arkansas • Aurora, Colorado • West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 30, 2026 · Synced Oct 21, 2026, 10:57 AM EDT
Completed Not applicable Interventional

Risks and Benefits of Naloxone Prescribing

NCT02535494
View directory record Official record
Conditions
Opioid Overdose
Interventions
Extensive training
Other
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 65 Years
Enrollment
405 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2022 · Synced Oct 21, 2026, 10:57 AM EDT
Completed No phase listed Observational

Quantitative Xylazine Measurement in ED

NCT06949605
View directory record Official record
Conditions
Opioid Overdose, Substance Use Disorders
Interventions
Not listed
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Elmhurst, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 21, 2026, 10:57 AM EDT
Terminated Phase 2 Interventional

Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose

NCT05517668
View directory record Official record
Conditions
Acetaminophen, Drug Overdose, Acetaminophen Overdose, Acetaminophen Poisoning, Drug-induced Liver Injury, Liver Failure, Liver Toxicity
Interventions
Intravenous infusion of N-acetylcysteine, Intravenous infusion of Fomepizole (4-MP)
Drug
Lead sponsor
Richard Dart, MD, PhD
Other
Eligibility
10 Years to 99 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Oct 21, 2026, 10:57 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Social Facilitation of Alcohol Effects and Alcohol Misuse in Young Adults

NCT06627803
View directory record Official record
Conditions
Alcohol Consumption, Alcohol Abuse/Dependence
Interventions
Alcohol (Oral)
Drug
Lead sponsor
University of Southern California
Other
Eligibility
21 Years to 28 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Oct 21, 2026, 10:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Text Intervention to Facilitate Secure Storage and Disposal of Prescription Opioids

NCT05503186
View directory record Official record
Conditions
Opioid Misuse
Interventions
Text Message, Standard of Care
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
479 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Oct 21, 2026, 10:57 AM EDT