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ClinicalTrials.gov public records Last synced Nov 14, 2026, 9:48 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 165 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use (Drugs, Alcohol) Clear all

Conditions: Alcohol Use Disorder (AUD), HIV
Interventions: semaglutide; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 99 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Decatur, Georgia

Conditions: Alcohol Consumption, Alcohol Use Disorder (AUD), Substance Use (Drugs, Alcohol), Substance Use Disorder (SUD), Condomless Sex, Unprotected Sex, High-risk Sex
Interventions: AWARE; Behavioral
Lead sponsor: RAND; Other
Eligibility: 18 Years to 25 Years
Enrollment: 360 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2027 – 2029
U.S. locations: 3
States / cities: Los Angeles, California • Venice, California • Pittsburgh, Pennsylvania

Conditions: Drink Too Much, Drinking, Binge, Drunk, Drug Use, Aggression, Aggression Sexual, Peer Group, Safety Issues, Harm Reduction
Interventions: Nightlife Safety Plans (NSP), Fire Safety; Behavioral
Lead sponsor: Pacific Institute for Research and Evaluation; Other
Eligibility: 21 Years and older
Enrollment: 959 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 2
States / cities: Berkeley, California

Conditions: Adherence, Tobacco Use Cessation, Alcohol & Drug Use, Nicotine Transdermal System
Interventions: Lifestyle counseling; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 25 Years
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2008
U.S. locations: 3
States / cities: Jacksonville, Florida • Rochester, Minnesota

Conditions: Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use
Interventions: Screening; Other
Lead sponsor: Baylor Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Alcohol Use Disorder
Interventions: Brief Negotiated Interview (BNI), BNI+facilitated provision of MAUD, Brief Negotiated Interview BNI+facilitated provision of MAUD+CBT4CBT; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 417 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Drug Use Disorders, Alcohol-Related Disorders, Substance Use Disorder (SUD)
Interventions: Care Navigation; Behavioral
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years and older
Enrollment: 360 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Drug Use Disorders, Illicit Drug Use, Alcohol-Related Disorders
Interventions: Health Coaching, Practice Facilitation, Standard Implementation; Behavioral
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years and older
Enrollment: 1,552 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Stress Disorders, Post-Traumatic, Alcohol Abuse, Substance-Related Disorders
Interventions: Seeking Safety, Sertraline, Pill placebo; Behavioral · Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 65 Years
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Depression, Anxiety, Substance Use, Stress, Psychological, Stress, Emotional, Alcohol Use, Unspecified, Drug Use, Covid19
Interventions: Mindfulness Based Cognitive Therapy for Resilience During COVID-19 plus CHAMindWell, Internet Cognitive Behavioral Therapy plus CHAMindWell, CHAMindWell; Behavioral
Lead sponsor: Cambridge Health Alliance; Other
Eligibility: 18 Years to 70 Years
Enrollment: 113 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Cambridge, Massachusetts

Conditions: Substance-related Disorders, Alcohol and Other Substance Use Prevention, Alcohol and Other Drug Use Disorders
Interventions: Thrive Digital Peer Platform (TDPP); Behavioral
Lead sponsor: Thrive Digital Health, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Solon, Ohio

Conditions: HIV, Substance Use Disorders, Substance Use, AIDS
Interventions: CC PrTNER; Behavioral
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 15 Years to 29 Years · Male only
Enrollment: 275 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Baltimore, Maryland • Philadelphia, Pennsylvania

Conditions: Opioid Use Disorder
Interventions: Managing Physical Reactions to Overwhelming Emotions (IMPROVE), Health Education Training (HET); Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Alcohol Use Disorder, Hiv, Tobacco Use Disorder
Interventions: Varenicline; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Decatur, Georgia

Conditions: Alcohol Dependence, Alcoholism, Drug Dependence
Interventions: Chronic Disease Management for substance abuse, Standard care; Behavioral
Lead sponsor: Boston Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 569 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: HIV/AIDS and Infections, Drug Abuse, Adolescent Behavior, Drug Usage, Alcohol Use, Mental Health, Tobacco Use, HIV Testing
Interventions: Storytelling 4 Empowerment; Device
Lead sponsor: University of Michigan; Other
Eligibility: 16 Years to 21 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 2
States / cities: Ann Arbor, Michigan • Flint, Michigan

Conditions: Alcoholism
Interventions: Prazosin medication, Placebo medication; Drug
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years and older
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Human Immunodeficiency Virus, Alcohol-Related Disorders, Drug Use
Interventions: Project Khanya; Behavioral
Lead sponsor: University of Maryland, College Park; Other
Eligibility: 18 Years to 65 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: College Park, Maryland

Conditions: Use; Tobacco, Harmful, Alcohol Abuse, Drug Abuse
Interventions: iMET, iMET/TE; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 12 Years to 21 Years
Enrollment: 121 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Sexually Transmitted Infection, Alcohol Use Complicating the Puerperium, Alcohol Use Complicating Pregnancy, Unspecified Trimester, Drug Use
Interventions: Health Check-up for Expectant Moms, Time, attention, and information-matched control; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older · Female only
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Drug Use Disorders, Illicit Drug Use, Alcohol-Related Disorders, Opioid Use Disorder
Interventions: Standard implementation, Health Coaching, Practice Facilitation; Behavioral
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years and older
Enrollment: 18,430 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Substance Use Disorders, Alcohol Use Disorder, Opioid Use Disorder
Interventions: Not listed
Lead sponsor: Boston University; Other
Eligibility: 18 Years and older
Enrollment: 185,810 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Opioid Use Disorder, Alcohol Use Disorder, Health Risk Behaviors, Criminal Behavior, Housing Problems, Overdose of Opiate
Interventions: Removing Barriers to Recovery; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 2
States / cities: Ann Arbor, Michigan • Ypsilanti, Michigan

Conditions: Attention Deficit Hyperactivity Disorder, Oppositional Defiant Disorder, Conduct Disorder, Substance Abuse
Interventions: Adolescent Skills Parent Management Parent-Adol Negotiation, Treatment as Usual; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 11 Years to 14 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Search by objective public record fields.

Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 3 Semaglutide

Implementing an Evidence-based Alcohol Use and Sexual Risk Intervention in Young Adult Homeless Service Settings

Group-based Intervention for Club Patrons

Smoking Cessation for Young Adults Who Binge Drink - 1

TAPS-ESP: Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use Electronic Spanish Platform

Promoting Alcohol Treatment Engagement Post-hospitalization

Addressing Barriers to Care for Substance Use Disorder Trial

An Initial Study of the Implementation of Digital Therapeutics for Substance Use Disorders in Primary Care

Combined Treatment for Alcohol-Dependent Individuals With PTSD

Remotely Delivered Programs Targeting COVID-19 Stress-Related Depression and Substance Use

Evaluating Feasibility, Acceptability, Usability, and an Initial Estimate of Effect of a Novel Training Platform on Peer Recovery Supporter Skill, Adherence, and Knowledge Gain-Phase I

The Collaborative Care PrTNER Study

Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD

Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2

Addiction Health Evaluation And Disease Management (AHEAD) Study

A Community-University Approach to Preventing HIV

Study of the Medication Prazosin for Alcohol Dependence

Effectiveness & Implementation of a Behavioral Intervention for Adherence and Substance Use in HIV Care in South Africa

Dental and Medical Office iMET to Reduce Teen Tobacco, Alcohol, and Drug Use

Technology-Based Intervention for Reducing Sexually Transmitted Infections and Substance Use During Pregnancy

Digital Treatments for Opioids and Other Substance Use Disorders in Primary Care

Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic

Removing Barriers: Community Partnering for Innovative Solutions to the Opioid Crisis

Home Based Treatment for Drug Use in Early Adolescents