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Showing 1–24 of 158 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Substance Use (Drugs, Alcohol) Clear all
Recruiting Phase 2 Interventional

Cannabidiol and Alcohol Use Disorder Phenotypes

NCT07279558
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Full-Spectrum Cannabidiol (CBD), Broad-Spectrum Cannabidiol (CBD), Placebo
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
21 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Phase 4 Interventional Results available

Dutasteride for the Reduction of Alcohol Use in Male Drinkers

NCT01262287
View directory record Official record
Conditions
Alcoholism, Alcohol Abuse, Alcohol Dependence
Interventions
Dutasteride, Placebo
Drug
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 19, 2017 · Synced Jul 21, 2026, 11:11 AM EDT
Completed No phase listed Observational

MOM NEST Study: Maternal Opioid Medication: Naltrexone Efficacy Study

NCT03718104
View directory record Official record
Conditions
Opioid-use Disorder, Neonatal Abstinence Syndrome, Pregnancy, High Risk, Alcohol Use Disorder
Interventions
Pharmacokinetic analysis, Safety and Efficacy, Genetic and epigenetic analysis, Breast milk analysis
Other · Genetic
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
2
States / cities
Boston, Massachusetts • Carrboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 3, 2024 · Synced Jul 21, 2026, 11:11 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP

NCT06552741
View directory record Official record
Conditions
Substance Use Disorder, Alcohol Use Disorder
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 99 Years
Enrollment
10,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2047
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Drug /Cue Interactions In Alcohol-Tobacco Comorbidity

NCT00816231
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Tobacco, Alcoholic Beverage, Placebo
Behavioral · Other
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
244 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2019
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 5, 2019 · Synced Jul 21, 2026, 11:11 AM EDT
Active, not recruiting Not applicable Interventional

Addressing Barriers to Care for Substance Use Disorder Pilot Study

NCT06317987
View directory record Official record
Conditions
Drug Use Disorders, Illicit Drug Use, Alcohol-Related Disorders
Interventions
Care Navigation
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Phase 2 Interventional Results available

Study of the Medication Prazosin for Alcohol Dependence

NCT00762710
View directory record Official record
Conditions
Alcoholism
Interventions
Prazosin medication, Placebo medication
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 3, 2020 · Synced Jul 21, 2026, 11:11 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Implementation Facilitation Pilot for Alcohol Use Disorder (AUD) in Alcohol-associated Liver Disease (ALD)

NCT07525258
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol-associated Liver Disease
Interventions
Implementation Intervention
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Phase 1Phase 2 Interventional

Dental and Medical Office iMET to Reduce Teen Tobacco, Alcohol, and Drug Use

NCT00907309
View directory record Official record
Conditions
Use; Tobacco, Harmful, Alcohol Abuse, Drug Abuse
Interventions
iMET, iMET/TE
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
12 Years to 21 Years
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 6, 2016 · Synced Jul 21, 2026, 11:11 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

First Years Away From Home: Letting Go and Staying Connected

NCT03227809
View directory record Official record
Conditions
Substance Abuse, Risk Reduction, RIsky Sexual Behavior
Interventions
Handbook condition, Handbook plus condition
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
17 Years to 22 Years
Enrollment
910 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Pullman, Washington
Source: ClinicalTrials.gov public record
Updated May 18, 2020 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Student Athlete Testing Using Random Notification

NCT00451854
View directory record Official record
Conditions
Drug Abuse, Alcohol Abuse, Substance Abuse
Interventions
Random, no advanced notice drug and alcohol testing
Procedure
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
13 Years to 19 Years
Enrollment
14,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2002
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Not applicable Interventional

Impact of Personalized Feedback Alone on Substance Use Behaviors

NCT01501318
View directory record Official record
Conditions
Substance Abuse
Interventions
Personalized feedback report, Personalized feedback report plus education
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 105 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Not applicable Interventional Results available

An Initial Study of the Implementation of Digital Therapeutics for Substance Use Disorders in Primary Care

NCT04907045
View directory record Official record
Conditions
Drug Use Disorders, Illicit Drug Use, Alcohol-Related Disorders
Interventions
Health Coaching, Practice Facilitation, Standard Implementation
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
1,552 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Jul 21, 2026, 11:11 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Project VALOR: Veteran Stress and Wellbeing

NCT06095817
View directory record Official record
Conditions
Alcohol Use Disorder, Depression
Interventions
Internet Delivered Brief Intervention (IDBI)
Behavioral
Lead sponsor
Cornell University
Other
Eligibility
18 Years to 62 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 14, 2025 · Synced Jul 21, 2026, 11:11 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Nen ŨnkUmbi/EdaHiYedo Plus (We Are Here Now Plus): a Multi-level Intervention to Reduce Health Disparities Among American Indian Youth

NCT07460973
View directory record Official record
Conditions
Healthy, Condom Use, Mental Health, Substance Use (Drugs, Alcohol)
Interventions
NE+, Control
Behavioral
Lead sponsor
Montana State University
Other
Eligibility
12 Years to 18 Years
Enrollment
843 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Jul 21, 2026, 11:11 AM EDT
Active, not recruiting Phase 2 Interventional

Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2

NCT06006143
View directory record Official record
Conditions
Alcohol Use Disorder, Hiv, Tobacco Use Disorder
Interventions
Varenicline
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Not applicable Interventional Results available

Technology-Based Intervention for Reducing Sexually Transmitted Infections and Substance Use During Pregnancy

NCT03826342
View directory record Official record
Conditions
Sexually Transmitted Infection, Alcohol Use Complicating the Puerperium, Alcohol Use Complicating Pregnancy, Unspecified Trimester, Drug Use
Interventions
Health Check-up for Expectant Moms, Time, attention, and information-matched control
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older · Female only
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 19, 2025 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Not applicable Interventional Results available

Study of the Effects of Motivational Enhancement Therapy on Alcohol Use in Chronic Hepatitis C Patients

NCT00596960
View directory record Official record
Conditions
Alcohol Dependence, Chronic Hepatitis C
Interventions
Motivational Enhancement Therapy (MET), Health education
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
2
States / cities
Minneapolis, Minnesota • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 27, 2014 · Synced Jul 21, 2026, 11:11 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Cultural Adaptation of Drug Treatment for DJJ Youth

NCT06003725
View directory record Official record
Conditions
Substance Use
Interventions
Culturally Adapted Adolescent Substance Use Treatment
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
13 Years to 17 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
2
States / cities
San Francisco, California • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Jul 21, 2026, 11:11 AM EDT
Not yet recruiting Not applicable Interventional

A Study Of Senyo Health With Comorbid Alcohol Use Disorder Treatment In Bipolar Patients

NCT07556861
View directory record Official record
Conditions
Bipolar Disorder, Substance Use (Drugs, Alcohol)
Interventions
Senyo Health App
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Not applicable Interventional

fMRI Study of a Dual Process Treatment Protocol With Substance Dependent Adults

NCT01320748
View directory record Official record
Conditions
Substance Abuse, Substance Dependence, Alcohol Abuse, Drug Use, Relapse
Interventions
Dual Processing, Relapse Prevention
Behavioral
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 29, 2018 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Phase 2 Interventional Results available

Medication Development in Alcoholism: Apremilast Versus Placebo

NCT03175549
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Apremilast, Placebo
Drug
Lead sponsor
The Scripps Research Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Sep 15, 2022 · Synced Jul 21, 2026, 11:11 AM EDT
Recruiting Not applicable Interventional

Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons

NCT06923423
View directory record Official record
Conditions
PTSD - Post Traumatic Stress Disorder, PTSD and Alcohol Use Disorder, PTSD and Trauma-related Symptoms, Substance Use Disorder (SUD), Depression, Mental Health, Trauma, Trauma Exposure, Traumatic Stress Disorder, Traumatic Stress, Post Traumatic Stress Symptoms
Interventions
Group Cognitive Processing Therapy (CPT), Control Group Individual trauma focused self-help via workbook
Behavioral
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years and older
Enrollment
640 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
6
States / cities
Little Rock, Arkansas • Osceola, Arkansas • Texarkana, Arkansas + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1

NCT00158288
View directory record Official record
Conditions
Behavior Therapy, Cocaine, Contingency Management, Heroin Dependence, LAAM, Opioid Dependence, Substance-Related Disorders, Alcohol & Drug Use
Interventions
LAAM
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 55 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1997 – 2001
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Jul 21, 2026, 11:11 AM EDT