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ClinicalTrials.gov public records Last synced Nov 15, 2026, 4:14 AM EST

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Showing 1–24 of 1,374 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Substance Use Behavior Clear all
Completed Phase 1 Interventional Results available

Developing a Smoking Cessation Intervention for Methadone Maintained Smokers

NCT01393392
View directory record Official record
Conditions
Nicotine Dependence, Opiate Dependence
Interventions
Intensive, tailored intervention, NJ Quitline Referral
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 6, 2018 · Synced Nov 15, 2026, 4:14 AM EST
Completed Not applicable Interventional

Developing an Intervention to Address Suicide Risk During Substance Use Disorder

NCT01127932
View directory record Official record
Conditions
Suicide, Substance-Related Disorders
Interventions
Psychoeducation for substance abuse, CBT for suicide in Substance abuse
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Waterford, Michigan
Source: ClinicalTrials.gov public record
Updated May 13, 2015 · Synced Nov 15, 2026, 4:14 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Novel Determinants and Measures of Smokeless Tobacco Use: Study 2

NCT01067599
View directory record Official record
Conditions
Tobacco Use Disorder, Nicotine Dependence
Interventions
Low nicotine, Medium nicotine, High nicotine
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
278 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
2
States / cities
Minneapolis, Minnesota • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 26, 2018 · Synced Nov 15, 2026, 4:14 AM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

Efficacy of a Multi-level School Intervention for LGBTQ Youth

NCT05541406
View directory record Official record
Conditions
Depression, Anxiety, Post Traumatic Stress Disorder, Coping Behavior, Sexual Minority Stress, Suicidality, Substance Use, Bullying, Harassment
Interventions
Proud & Empowered, Control Group
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
12 Years to 20 Years
Enrollment
228 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
23
States / cities
El Monte, California • Glendale, California • Inglewood, California + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Nov 15, 2026, 4:14 AM EST
Not yet recruiting Phase 3 Interventional Accepts healthy volunteers

Implementing an Evidence-based Alcohol Use and Sexual Risk Intervention in Young Adult Homeless Service Settings

NCT07933406
View directory record Official record
Conditions
Alcohol Consumption, Alcohol Use Disorder (AUD), Substance Use (Drugs, Alcohol), Substance Use Disorder (SUD), Condomless Sex, Unprotected Sex, High-risk Sex
Interventions
AWARE
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years to 25 Years
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2029
U.S. locations
3
States / cities
Los Angeles, California • Venice, California • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 12, 2026 · Synced Nov 15, 2026, 4:14 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Prize Reinforcement for Smoking Cessation

NCT00865254
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Standard Treatment, Traditional Contingency Management, Early Enhanced Contingency Management
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
13 Years and older
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 28, 2013 · Synced Nov 15, 2026, 4:14 AM EST
Completed Phase 1Phase 2 Interventional Results available

Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain

NCT00129246
View directory record Official record
Conditions
Smoking, Nicotine Dependence
Interventions
Naltrexone, Bupropion
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 3, 2020 · Synced Nov 15, 2026, 4:14 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Web-delivery of Evidence-based, Psychosocial Treatment for Substance Use Disorders

NCT01104805
View directory record Official record
Conditions
Substance Abuse
Interventions
Therapeutic Education System (TES), Treatment-as-Usual (TAU)
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
507 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
10
States / cities
Danbury, Connecticut • Orlando, Florida • Waipahu, Hawaii + 7 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2017 · Synced Nov 15, 2026, 4:14 AM EST
Completed Not applicable Interventional Results available

Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care

NCT03217058
View directory record Official record
Conditions
Substance Use Disorders, HIV, Depression, Anxiety
Interventions
Clinic-based screening and behavioral interventions
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
Not listed
Enrollment
10,821 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Nov 15, 2026, 4:14 AM EST
Completed Early Phase 1 Interventional Accepts healthy volunteers

Dental Tobacco Control.Net:Improving Practice

NCT00627185
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Internet-delivered continuing professional development, No intervention arm
Behavioral · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 9, 2015 · Synced Nov 15, 2026, 4:14 AM EST
Completed Phase 1 Interventional Accepts healthy volunteers

The Effects of Memantine and Bupropion on Acute, Reinforcing, and Conditioned Effects of Cigarettes - 1

NCT00136747
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Memantine, bupropion, placebo
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 21, 2018 · Synced Nov 15, 2026, 4:14 AM EST
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence

NCT00749658
View directory record Official record
Conditions
Nicotine Dependence, Nicotine Withdrawal
Interventions
Bupropion, Varenicline
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Nov 15, 2026, 4:14 AM EST
Completed Phase 3 Interventional Accepts healthy volunteers Results available

SSRI and Buprenorphine

NCT00475878
View directory record Official record
Conditions
Opiate Dependence, Depression
Interventions
escitalopram, placebo
Drug
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 3, 2012 · Synced Nov 15, 2026, 4:14 AM EST
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

School Nurse-Delivered Smoking Cessation Intervention

NCT00682474
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Dependence
Interventions
Counseling Intervention, Information Intervention
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
13 Years to 18 Years
Enrollment
1,058 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 19, 2011 · Synced Nov 15, 2026, 4:14 AM EST
Completed Phase 2 Interventional Accepts healthy volunteers Results available

N-acetylcysteine for Tobacco Use Disorder

NCT02737358
View directory record Official record
Conditions
Nicotine Dependence, Smoking
Interventions
N-acetylcysteine (NAC), Placebo
Drug · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 17, 2020 · Synced Nov 15, 2026, 4:14 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine and Cannabis Vape Labeling Experiment - Spring 2025

NCT06919276
View directory record Official record
Conditions
Vaping, Adolescent, Electronic Cigarette Use, Nicotine, Cannabis
Interventions
Vaping Device Labeling
Other
Lead sponsor
University of Southern California
Other
Eligibility
11 Years to 19 Years
Enrollment
3,048 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Nov 15, 2026, 4:14 AM EST
Completed Not applicable Interventional

Tobacco Treatment Medical Education in 10 Medical Schools

NCT01905618
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking Cessation
Interventions
Web-based curriculum on tobacco dependence treatment, Tobacco Counseling Role Play, Preceptor Training and Teaching Medical Students, Booster Session
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
13
States / cities
Birmingham, Alabama • Stanford, California • Washington D.C., District of Columbia + 10 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2015 · Synced Nov 15, 2026, 4:14 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Randomized Trial of the Positive Action Program in Chicago Schools and Extension to Grade 8

NCT01025674
View directory record Official record
Conditions
Character, Violence, Substance Use, Pro-Social Behavior, Academic Achievement
Interventions
Positive Action program
Behavioral
Lead sponsor
Oregon State University
Other
Eligibility
6 Years and older
Enrollment
4,230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2010
U.S. locations
2
States / cities
Chicago, Illinois • Corvallis, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 22, 2015 · Synced Nov 15, 2026, 4:14 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

WayToServePlus: Improving Responsible Alcohol Service Ph II

NCT05779774
View directory record Official record
Conditions
Alcohol Drinking, Alcohol Intoxication, Alcohol Use, Unspecified
Interventions
WayToServe Plus In-service Component, WayToServe Training Only
Behavioral
Lead sponsor
Klein Buendel, Inc.
Industry
Eligibility
19 Years and older
Enrollment
216 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Golden, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Nov 15, 2026, 4:14 AM EST
Recruiting Phase 2Phase 3 Interventional

A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation

NCT07487818
View directory record Official record
Conditions
Smoking Cessation
Interventions
Non-invasive vagus nerve stimulator plus nicotine replacement patches, nicotine replacement patches
Combination Product · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Nov 15, 2026, 4:14 AM EST
Completed Phase 4 Interventional

Treating Alcohol Use In Older Adults With Depression

NCT00018824
View directory record Official record
Conditions
Alcoholism, Depression
Interventions
NALTREXONE, Placebo
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
55 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2005
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 23, 2009 · Synced Nov 15, 2026, 4:14 AM EST
Recruiting Phase 1 Interventional

Semaglutide Dose Effects on Metabolic and Stress Hormone, Craving and Alcohol Use Outcomes

NCT07772960
View directory record Official record
Conditions
Alcohol Use Disorder (AUD), Obesity (BMI Equal to or >30)
Interventions
Placebo, Semaglutide 1.0 mg, Semaglutide 2.0 mg
Other · Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 68 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 4, 2026 · Synced Nov 15, 2026, 4:14 AM EST
Recruiting Phase 1 Interventional Accepts healthy volunteers

Open-Label Psilocybin Study in Transdiagnostic Population

NCT06442423
View directory record Official record
Conditions
Transdiagnostic, Depression - Major Depressive Disorder, Anxiety, PTSD Symptoms, PTSD, Substance Use, Substance Use Disorder (SUD), OCD
Interventions
Psilocybin
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 30, 2026 · Synced Nov 15, 2026, 4:14 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Group-based Intervention for Club Patrons

NCT03652688
View directory record Official record
Conditions
Drink Too Much, Drinking, Binge, Drunk, Drug Use, Aggression, Aggression Sexual, Peer Group, Safety Issues, Harm Reduction
Interventions
Nightlife Safety Plans (NSP), Fire Safety
Behavioral
Lead sponsor
Pacific Institute for Research and Evaluation
Other
Eligibility
21 Years and older
Enrollment
959 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
2
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Jan 14, 2025 · Synced Nov 15, 2026, 4:14 AM EST