Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:14 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 217–240 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Nicotine Dependence
Interventions: Quit Line plus MTS, Quit Line Only; Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 196 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Alcohol Use Disorder, Attention Deficit Hyperactivity Disorder
Interventions: Tolcapone, Placebo; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 21 Years to 65 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Nicotine Dependence
Interventions: Varenicline, Placebo, Smoking Cessation Counseling; Drug · Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 179 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Depression, Anxiety, Substance Use Disorders
Interventions: Behavioral Health - Virtual Patient Navigation; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 1,089 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 9
States / cities: Albemarle, North Carolina • Kings Mountain, North Carolina • Laurinburg, North Carolina + 6 more

Conditions: Tobacco Abstinence
Interventions: Varenicline; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Nicotine Dependence
Interventions: Standard treatment, Standard treatment+practice quitting, Very low nicotine cigarettes; Behavioral · Drug
Lead sponsor: Rutgers University; Other
Eligibility: 18 Years and older
Enrollment: 93 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Substance Use Disorders
Interventions: Adherence to ASAM protocols, Non-adherence to ASAM protocols; Other
Lead sponsor: RTI International; Other
Eligibility: 19 Years and older
Enrollment: 991 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Research Triangle Park, North Carolina

Conditions: Nicotine Dependence
Interventions: Not listed
Lead sponsor: American University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 130 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Nicotine Dependence
Interventions: Not listed
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 60 Years
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Nicotine Dependence, Smoking, Sleep Disorders, Intrinsic
Interventions: Exercise; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 45 Years
Enrollment: 88 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Stress Disorders, Post-Traumatic, Opioid Use Disorder
Interventions: Written Exposure Therapy - Integrated; Behavioral
Lead sponsor: Jesse McCann; Other
Eligibility: 18 Years to 100 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Opioid Use Disorder, Opioid Abuse and Addiction, Narcotic-Related Disorders, Substance-Related Disorders, Chemically-Induced Disorders, Mental Disorder, Opioid
Interventions: Semaglutide Pen Injector, Placebo; Drug
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 4
States / cities: Baltimore, Maryland • Fall River, Massachusetts • New York, New York + 1 more

Conditions: Opioid Use Disorder, Alcohol Use Disorder, Health Risk Behaviors, Criminal Behavior, Housing Problems, Overdose of Opiate
Interventions: Removing Barriers to Recovery; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 2
States / cities: Ann Arbor, Michigan • Ypsilanti, Michigan

Conditions: Opioid-use Disorder
Interventions: imFREE mCBT, mHealth ED; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: Tarzana, California

Conditions: Cigarette Smoking, Nicotine Dependence
Interventions: Internet Smoking Cessation Web Site; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 90 Years
Enrollment: 146 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Smoking, Smoking, Tobacco, Tobacco Use Disorder
Interventions: Smoking cessation counseling (Quitline), Smoking cessation pharmacotherapy (e.g, nicotine replacement therapy), Financial incentives; Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 182 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance-Related Disorders, Depressive Disorder, Behavioral Symptoms, Risk-Taking, Sexual Behavior
Interventions: LETS ACT, LETS ACT-SE, Treatment as Usual; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 55 Years
Enrollment: 206 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 2
States / cities: Chapel Hill, North Carolina • Raleigh, North Carolina

Conditions: Sexual Assault, Substance Use, Risky Health Behavior, Ema
Interventions: Ecological Momentary Intervention; Behavioral
Lead sponsor: University of New Mexico; Other
Eligibility: 18 Years to 24 Years · Female only
Enrollment: 183 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Depression, Substance-Related Disorders, HIV Infections
Interventions: Antidepressant Medication; Drug
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 75 Years
Enrollment: 265 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2004
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Nicotine Dependence
Interventions: Nicotine; Drug
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Overdose
Interventions: Not listed
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 500 participants
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Tobacco Use Disorder
Interventions: Modified Project Toward No Tobacco Use; Behavioral
Lead sponsor: Wayne State University; Other
Eligibility: 14 Years to 18 Years
Enrollment: 2,300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2000 – 2006
U.S. locations: 1
States / cities: Dearborn, Michigan

Conditions: Vaping
Interventions: Social Media Intervention; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 13 Years to 21 Years
Enrollment: 500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Nicotine Dependence, Electronic Cigarette Use, Cigarette Smoking
Interventions: Nicotine, Juul e-cigarette, Reduction; Drug · Device · Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 21 Years and older
Enrollment: 77 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Burlington, Vermont

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Trial on the Effectiveness of Mindfulness Training for Smokers

COMT Inhibition Among Individuals With Comorbid AUD/ADHD

Varenicline for Nicotine Dependence Among Those With HIV/AIDS

A Virtual Navigation Intervention to Reduce Behavioral Health Admissions From Rural Emergency Departments

Varenicline For Smokers In Recovery From Alcohol Dependence

Evaluation of Learning-Theory-Based Smoking Cessation Strategies

Patient Centered Assessment and Substance Use Disorder Treatment Study (PCAST)

The Effect of Smoking on Perception

Cue Induced Imaging in Nicotine Dependent Smokers

The Effect of Exercise on Acute Nicotine Withdrawal

New Beginnings Following Trauma

GLP-1R Agonist Treatment for Opioid Use Disorder

Removing Barriers: Community Partnering for Innovative Solutions to the Opioid Crisis

Effectiveness of a CBT-based mHealth Intervention Targeting MOUD Retention, Adherence, and Opioid Use

Comparison of Internet Stop Smoking Intervention to Usual Care on Smoking Cessation at 6 Months

Financial Incentives for Smoking Treatment

Technology Enhanced Behavioral Activation Treatment for Substance Use

Nexus of Risk: Sexual Assault, Alcohol Use, and Risky Sex Among College Women

Antidepressant Medication for Reducing HIV Risk Behavior in Depressed Intravenous Drug Users

Effects of Menthol in E-cigarettes on Smoking Behaviors

Overdose Prevention Centers and Behavioral Health

Tobacco Use Among Arab American Youth

Social Media Intervention to Stop Nicotine and Cannabis Vaping Among Adolescents

E-cigarette Nicotine Study