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ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:31 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 241–264 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Tobacco Dependence
Interventions: Enhanced Web Assisted Tobacco Intervention, Basic Web Assisted Tobacco Intervention; Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 1,452 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Attention Deficit Hyperactivity Disorder, Oppositional Defiant Disorder, Conduct Disorder, Substance Abuse
Interventions: Adolescent Skills Parent Management Parent-Adol Negotiation, Treatment as Usual; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 11 Years to 14 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Binge Drinking, HIV
Interventions: Placebo, Naltrexone, Medical Management (MM) counseling for alcohol use:, Urinalysis for novel alcohol biochemical markers:, Behavioral survey measurements:, Dried Blood Spot (DSB) Testing for Phosphatidylethanol, Ecological Momentary Assessment; Drug · Behavioral · Diagnostic Test
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 70 Years · Male only
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: San Francisco, California

Conditions: HIV/AIDS, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Depression, Substance Use
Interventions: Counselor delivered telehealth intervention; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 29 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Alcohol Consumption, Alcohol Drinking, Alcohol Intoxication
Interventions: Alcohol beverage, Non-alcohol beverage; Drug · Other
Lead sponsor: Carnegie Mellon University; Other
Eligibility: 21 Years to 30 Years
Enrollment: 504 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Opioid-use Disorder, Addiction, Depression, Post-traumatic Stress Disorder
Interventions: Collaborative Care; Behavioral
Lead sponsor: RAND; Other
Eligibility: 18 Years and older
Enrollment: 729 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 16
States / cities: Los Angeles, California • Santa Monica, California • Albuquerque, New Mexico + 5 more

Conditions: Alcohol Use Disorder, Opioid Use Disorder, Alcohol Use, Opioid Use
Interventions: Brief opioid-informed alcohol treatment; Behavioral
Lead sponsor: University of Notre Dame; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Notre Dame, Indiana

Conditions: Alcohol Drinking, Alcohol Use, Unspecified, Alcohol Abstinence, Alcohol-Related Disorders
Interventions: Endourage 1200 mg OMD ™ Oral Mucosal Drops, Isolate, Placebo, Peppermint Oil, masking flavor; Dietary Supplement · Other
Lead sponsor: Endourage, LLC; Industry
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Novato, California

Conditions: Nicotine Dependence
Interventions: Nicotine; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 50 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Nicotine Dependence, Smoking Cessation
Interventions: Nicotrol Inhaler, Placebo Inhaler; Drug
Lead sponsor: UConn Health; Other
Eligibility: 16 Years and older · Female only
Enrollment: 154 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2017
U.S. locations: 2
States / cities: Hartford, Connecticut • Springfield, Massachusetts

Conditions: Major Depressive Disorder, Opioid Use Disorder, Suicidality
Interventions: Repetitive Transcranial Magnetic Stimulation; Device
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 64 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma, Fibromyalgia, Seizures, Hepatitis C, Cancer, Crohn Disease, HIV/AIDS, Multiple Sclerosis, Traumatic Brain Injury, Sickle Cell Disease, Post Traumatic Stress Disorder, Tourette Syndrome, Ulcerative Colitis, Glaucoma, Epilepsy, Inflammatory Bowel Diseases, Parkinson Disease, Amyotrophic Lateral Sclerosis, Chronic Traumatic Encephalopathy, Anxiety, Depression, Insomnia, Autism, Opioid-use Disorder, Bipolar Disorder, Covid19, SARS-CoV Infection, COVID-19, Corona Virus Infection, Coronavirus
Interventions: Cannabis, Medical, RYAH-Medtech Inhaler; Drug · Device
Lead sponsor: OMNI Medical Services, LLC; Network
Eligibility: 7 Years and older
Enrollment: 200,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2025
U.S. locations: 17
States / cities: Boca Raton, Florida • Bradenton, Florida • Fort Lauderdale, Florida + 13 more

Conditions: Cannabis Use Disorder, Anxiety, Depression, Anxiety, Depression - Major Depressive Disorder
Interventions: Therabot-CALM; Device
Lead sponsor: Trustees of Dartmouth College; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Opioid-use Disorder, Opioid Misuse, Opioid Use, Chronic Pain
Interventions: Care Continuity Program; Other
Lead sponsor: Sure Med Compliance; Industry
Eligibility: 18 Years and older
Enrollment: 1,840 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Mobile, Alabama

Conditions: Opioid Use Disorder, Insomnia
Interventions: Sleep Hygiene, Mindfulness; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Alcohol Use Disorder
Interventions: Episodic Future Thinking, Control Episodic Thinking; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 154 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Alcohol Use Disorder, Obesity and Overweight, Alcohol
Interventions: Tirzepatide, Placebo injections; Drug
Lead sponsor: University of Southern California; Other
Eligibility: 21 Years to 65 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Substance Use Disorders
Interventions: Technology Augmented Treatment for Screening, Brief Intervention, Referral, and Treatment (SBIRT); Behavioral
Lead sponsor: Washington State University; Other
Eligibility: 21 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Spokane Valley, Washington

Conditions: Opioid Overdose, Opioid Use, Opioid Use Disorder, Opioids
Interventions: EHR-Embedded Elevated-Risk Flag, EHR-Embedded Elevated-Risk Flag with Behavioral Nudges, Usual Care; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 1,350 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Substance-Related Disorders
Interventions: Behavior Therapy; Behavioral
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years to 99 Years · Female only
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2006
U.S. locations: 6
States / cities: Indianapolis, Indiana • Louisville, Kentucky • Detroit, Michigan + 2 more

Conditions: Sexually Transmitted Infection, Substance Use, Abuse, Pregnancy
Interventions: Project IMAGE; Behavioral
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 14 Years to 18 Years · Female only
Enrollment: 562 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2009
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Alcohol Use Disorder With Insomnia
Interventions: Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene Education; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 82 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 2
States / cities: Coatesville, Pennsylvania • Philadelphia, Pennsylvania

Conditions: Tobacco Dependence
Interventions: Nicotine-Containing Electronic Cigarette, Non-Nicotine Electronic Cigarette; Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years to 70 Years
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: HIV Prevention, PTSD and Substance Use Disorder
Interventions: Narrative Exposure Therapy (NET), Motivational Interviewing w/Skills Training (MIST); Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 16 Years and older
Enrollment: 125 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2024
U.S. locations: 1
States / cities: Seattle, Washington

Search by objective public record fields.

Web Assisted Tobacco Intervention With Community Colleges

Home Based Treatment for Drug Use in Early Adolescents

Better Than Study: Targeting Heavy Alcohol Use With Naltrexone Among Men Who Have Sex With Men (MSM)

Youth to Text or Telehealth for Engagement in HIV Care

Drinking in Young Adult Duos (DYAD) Study

Collaboration Leading to Addiction Treatment and Recovery From Other Stresses

Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment

Endourage Complete Spectrum Oral Mucosal Drops (OMD) in Adults Desiring a Reduction in Ethanol Use

Effects of Nicotine on Brain Opioid Receptors

Nicotine Replacement for Smoking Cessation During Pregnancy

Cortical rTMS as a Treatment for Depression

Outcomes Mandate National Integration With Cannabis as Medicine

Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use

Comparing a Patient Self-Assessment Software to Treatment as Usual in Opioid Prescriber and Patient Opioid Outcomes

Improving Insomnia in Patients With Opioid Use Disorder

Increasing the Temporal Window in Individuals With Alcohol Use Disorder

Tirzepatide for Alcohol Use Disorder

Technologically-Augmented Referrals to Mitigate Addiction Consequences

Machine-Learning Prediction and Reducing Overdoses With EHR Nudges

Motivational Enhancement Therapy to Improve Treatment Utilization in Pregnant Substance Users - 1

Behavioral Intervention for Minority Adolescent Women

CBT-I Augmentation of Medication for Drinking in AUD

Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers

Preventing HIV Among Native Americans Through the Treatment PTSD & Substance Use